FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tsp74F1
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General Information
Symbol
Dmel\Tsp74F1
Species
D. melanogaster
Name
FlyBase ID
FBal0283692
Feature type
allele
Associated gene
Dmel\Tsp74F
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Han et al., 2012)
Mutagen
P-element activity
(Han et al., 2012)
Progenitor genotype
P{EPgy2}Tsp74FEY04256
(Han et al., 2012)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a deletion that removes part of Tsp74F.

(Han et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The hatching rate of eggs laid by homozygous females is significantly reduced compared to wild type, although the number of eggs laid is similar to wild type. The eggs are reduced in length.

      (Han et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Tsp74F[+]/Tsp74F1, Tsp66E2/Tsp66E2 is an enhancer of visible phenotype of if3

      (Han et al., 2012)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Tsp74F[+]/Tsp74F1, Tsp66E2/Tsp66E2 is an enhancer of wing phenotype of if3

      (Han et al., 2012)
      Other
      Statement
      Reference

      Tsp66E2, Tsp74F1 has actin filament phenotype

      (Han et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      At stage 12 of oogenesis, alignment of actin filament bundles in the follicle cells of Tsp66E2 Tsp74F1 double mutant females is severely disturbed. Endocytosis is severely reduced (assayed by dextran uptake) in the mutant follicle cells at this stage.

      The penetrance of the if3 wing blister phenotype is enhanced if the flies also carry Tsp66E2/Tsp66E2 Tsp74F1.

      (Han et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Tsp74F1
      (Han et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)