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General Information
Symbol
Dmel\brmK804R.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0086706
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
brmK804R
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: K804R. K804R falls in the ATP-binding site.

Amino acid replacement: K804R.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies carrying one or two copies of brmK804R.T:Ivir\HA1 are viable. Flies carrying two copies of brmK804R.T:Ivir\HA1 in a wild-type background frequently show partial transformation of haltere to wing, as shown by an increase in haltere size and the appearance of ectopic bristles on the capitellum. This phenotype is also seen in Df(3L)th102/+ animals carrying two copies of brmK804R.T:Ivir\HA1. brm2/Df(3L)th102 animals carrying two copies of brmK804R.T:Ivir\HA1 do not survive to adulthood.

Female brm deficiency heterozygotes carrying an X-linked copy of brmK804R.T:Ivir\HA1 survive to adulthood, but males of this genotype are not viable.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

brmK804R.Tag:HA/brm[+] is a suppressor of visible | dominant phenotype of EgfrE3

Other
Phenotype Manifest In
Suppressor of
Statement
Reference

brmK804R.Tag:HA/brm[+] is a suppressor of eye phenotype of EgfrE3

brmK804R.Tag:HA is a suppressor of eye phenotype of CycEJP

Additional Comments
Genetic Interactions
Statement
Reference

The small rough eye phenotype of EgfrE3/+ is suppressed by expression of the brmK804R.T:Ivir\HA1 genomic construct.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to rescue
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

An engineered dominant-negative mutation.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
  • FBal0086704
References (9)