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General Information
Symbol
Dmel\Hsc70-454.1
Species
D. melanogaster
Name
FlyBase ID
FBal0124173
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

T15245498C

Reported nucleotide change:

T?C

Amino acid change:

L380P | Hsc70-4-PA; L380P | Hsc70-4-PB; L380P | Hsc70-4-PC; L380P | Hsc70-4-PD; L380P | Hsc70-4-PE; L380P | Hsc70-4-PF; L380P | Hsc70-4-PG

Reported amino acid change:

L380P

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: T?C. Amino acid replacement: L380P.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Hsc70-454.1/+ suppresses position effect variegation at the w locus caused by P{SUPor-P}KV00108.

4% of adult heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 1% of adult heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). No extra sex combs are seen in heterozygotes. Homozygotes survive embryogenesis but die as larvae before the third instar. Heterozygous and homozygous larvae do not show any obvious homeotic phenotypes. However, 7% of heterozygous larvae that have a maternally inherited copy of Hsc70-454.1 show either partial or complete loss of one or more denticle belts, predominantly in the A4 segment. 13% of homozygous larvae show this phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

Hsc70-4[+]/Hsc70-454.1 is an enhancer of visible | dominant | homeotic phenotype of Pc3

NOT Enhancer of
Statement
Reference
NOT Suppressor of
Statement
Reference
Other
Phenotype Manifest In
Enhancer of
Statement
Reference

Hsc70-4[+]/Hsc70-454.1 is an enhancer of sex comb | ectopic phenotype of ph-p410

Hsc70-454.1 is an enhancer of phenotype of Pc5

Hsc70-4[+]/Hsc70-454.1 is an enhancer of sex comb | ectopic phenotype of Asx3

Hsc70-4[+]/Hsc70-454.1 is an enhancer of sex comb | ectopic phenotype of Pcl1

Hsc70-4[+]/Hsc70-454.1 is an enhancer of abdominal tergite 4 | male phenotype of Pc3

Hsc70-4[+]/Hsc70-454.1 is an enhancer of abdominal tergite 6 | male phenotype of Pc3

Hsc70-4[+]/Hsc70-454.1 is an enhancer of adult abdominal segment 4 phenotype of Pc3

Hsc70-4[+]/Hsc70-454.1 is an enhancer of adult abdominal segment 5 | ectopic phenotype of Pc3

Hsc70-4[+]/Hsc70-454.1 is an enhancer of adult abdominal segment 6 phenotype of Pc3

Hsc70-4[+]/Hsc70-454.1 is an enhancer of adult abdominal segment 7 | ectopic phenotype of Pc3

Hsc70-4[+]/Hsc70-454.1 is an enhancer of sex comb | ectopic phenotype of Pc3

NOT Enhancer of
Statement
Reference
NOT Suppressor of
Statement
Reference
Other
Statement
Reference

Hsc70-4[+]/Hsc70-454.1, Pc3 has wing phenotype

Additional Comments
Genetic Interactions
Statement
Reference

Flies carrying wIR.GMR in which the eyes are homozygous for Hsc70-454.1 have small, rough eyes. There is no increase in eye pigmentation compared to wIR.GMR single mutant flies.

100% of Hsc70-454.1 Pc3 double heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 100% of Hsc70-454.1 Pc3 double heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). There is an average of 34 extra sex combs (average total number of extra sex comb teeth on the four posterior legs of a male) in Hsc70-454.1 Pc3 double heterozygotes. Transformation of the first abdominal tergite towards A2 segment identity is seen in Hsc70-454.1 Pc3 double heterozygotes. The seventh tergite and sternite are almost completely removed, partially transformed into A8. Patches of wing tissue are transformed to haltere. 50% of flies show partial antenna-to-leg transformations. The progeny of Hsc70-454.1 Pc3 double heterozygous females often die as first instar larvae, even when fathers are wild type, but Hsc70-454.1 Pc3 double heterozygous males give viable offspring when mated to wild-type females. 26% of Hsc70-454.1 Asx3 double heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 7% of Hsc70-454.1 Asx3 double heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). There is an average of 0.8 extra sex combs (average total number of extra sex comb teeth on the four posterior legs of a male) in Hsc70-454.1 Asx3 double heterozygotes. 70% of Hsc70-454.1 Pcl1 double heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 35% of Hsc70-454.1 Pcl1 double heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). There is an average of 1.6 extra sex combs (average total number of extra sex comb teeth on the four posterior legs of a male) in Hsc70-454.1 Pcl1 double heterozygotes. 64% of Hsc70-454.1 ScmD1 double heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 6% of Hsc70-454.1 ScmD1 double heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). No extra sex combs are seen in Hsc70-454.1 ScmD1 double heterozygotes. ph-p410 Hsc70-454.1/+ males die as pharate adults with complete ectopic sex combs on the second and third thoracic legs. These animals show malformed or missing abdominal tergites and sternites, a reduced number of thoracic bristles, and missing aristae.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Selected as: an enhancer of the Pc5 phenotype.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (4)