FlyBase Allele Report: Dmel\Hsc70-4[54.1]

General Information

Symbol

Dmel\Hsc70-4^54.1

Species

D. melanogaster

Name

FlyBase ID

FBal0124173

Feature type

allele

Associated gene

Dmel\Hsc70-4

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl nitrosourea

Nature of the Allele

Allele class

Mutagen

ethyl nitrosourea

(Mollaaghababa et al., 2001)

Progenitor genotype

Cytology

Description

Nucleotide substitution: T?C. Amino acid replacement: L380P.

(Mollaaghababa et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:15,245,498..15,245,498 [+]

Nucleotide change:

T15245498C

Reported nucleotide change:

T?C

Amino acid change:

Reported amino acid change:

L380P

(Mollaaghababa et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

abdominal 4 ventral denticle belt

(Mollaaghababa et al., 2001)

adult abdominal segment 4

(Mollaaghababa et al., 2001)

adult abdominal segment 5 | ectopic

(Mollaaghababa et al., 2001)

adult abdominal segment 6

(Mollaaghababa et al., 2001)

adult abdominal segment 7 | ectopic

(Mollaaghababa et al., 2001)

ventral denticle belt

(Mollaaghababa et al., 2001)

Detailed Description

Statement

Reference

Hsc70-4^54.1/+ suppresses position effect variegation at the w locus caused by P{SUPor-P}KV00108.

(Swenson et al., 2016)

4% of adult heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 1% of adult heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). No extra sex combs are seen in heterozygotes. Homozygotes survive embryogenesis but die as larvae before the third instar. Heterozygous and homozygous larvae do not show any obvious homeotic phenotypes. However, 7% of heterozygous larvae that have a maternally inherited copy of Hsc70-4^54.1 show either partial or complete loss of one or more denticle belts, predominantly in the A4 segment. 13% of homozygous larvae show this phenotype.

(Mollaaghababa et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Hsc70-4[+]/Hsc70-4^54.1 is an enhancer of visible | dominant | homeotic phenotype of Pc³

(Mollaaghababa et al., 2001)

NOT Enhancer of

Statement

Reference

Hsc70-4^54.1 is a non-enhancer of visible phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Mollaaghababa et al., 2001)

NOT Suppressor of

Statement

Reference

Hsc70-4^54.1 is a non-suppressor of abnormal eye color phenotype of w^RNAi.GMR

(Zhou et al., 2008)

Hsc70-4^54.1 is a non-suppressor of visible phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Mollaaghababa et al., 2001)

Other

Statement

Reference

Asx³, Hsc70-4[+]/Hsc70-4^54.1 has visible | dominant | homeotic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pc³ has lethal | maternal effect | larval stage phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, ph-p⁴¹⁰ has lethal | pharate adult stage phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4^54.1 has visible | dominant | homeotic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pcl¹ has visible | dominant | homeotic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Scm^D1 has visible | dominant | homeotic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pc³ has lethal | maternal effect | larval stage phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pcl¹ has visible | dominant | homeotic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Scm^D1 has visible | dominant | homeotic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, brm^K804R.Tag:HA has viable | male phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, ph-p⁴¹⁰ has lethal | pharate adult stage phenotype

(Mollaaghababa et al., 2001)

Phenotype Manifest In

Enhancer of

Statement

Reference

Hsc70-4[+]/Hsc70-4^54.1 is an enhancer of sex comb | ectopic phenotype of ph-p⁴¹⁰

(Mollaaghababa et al., 2001)

Hsc70-4^54.1 is an enhancer of phenotype of Pc⁵

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1 is an enhancer of sex comb | ectopic phenotype of Asx³

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1 is an enhancer of sex comb | ectopic phenotype of Pcl¹

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1 is an enhancer of abdominal tergite 4 | male phenotype of Pc³

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1 is an enhancer of abdominal tergite 6 | male phenotype of Pc³

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1 is an enhancer of adult abdominal segment 4 phenotype of Pc³

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1 is an enhancer of adult abdominal segment 5 | ectopic phenotype of Pc³

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1 is an enhancer of adult abdominal segment 6 phenotype of Pc³

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1 is an enhancer of adult abdominal segment 7 | ectopic phenotype of Pc³

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1 is an enhancer of sex comb | ectopic phenotype of Pc³

(Mollaaghababa et al., 2001)

NOT Enhancer of

Statement

Reference

Hsc70-4[+]/Hsc70-4^54.1 is a non-enhancer of adult abdominal segment 5 phenotype of trx^B11

(Mollaaghababa et al., 2001)

Hsc70-4^54.1 is a non-enhancer of eye phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Mollaaghababa et al., 2001)

NOT Suppressor of

Statement

Reference

Hsc70-4^54.1 is a non-suppressor of eye phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Mollaaghababa et al., 2001)

Other

Statement

Reference

Asx³, Hsc70-4[+]/Hsc70-4^54.1 has adult abdominal segment 4 phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pc³ has abdominal tergite 1 phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pc³ has antenna phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pc³ has abdominal tergite 7 phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pc³ has haltere | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pc³ has adult abdominal segment 2 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pc³ has adult abdominal segment 8 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, ph-p⁴¹⁰ has arista phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, ph-p⁴¹⁰ has mesothoracic leg phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4[+]/Hsc70-4^54.1 has adult abdominal segment 6 phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, ph-p⁴¹⁰ has adult thoracic sensillum phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, ph-p⁴¹⁰ has abdominal tergite phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, ph-p⁴¹⁰ has abdominal sternite phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4^54.1 has adult abdominal segment 4 phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4^54.1 has adult abdominal segment 6 phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4^54.1 has adult abdominal segment 5 | ectopic phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4^54.1 has abdominal tergite 6 | male phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4^54.1 has abdominal tergite 4 | male phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4[+]/Hsc70-4^54.1 has adult abdominal segment 5 | ectopic phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4^54.1 has adult abdominal segment 7 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pcl¹ has adult abdominal segment 4 phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pcl¹ has adult abdominal segment 6 phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pcl¹ has adult abdominal segment 5 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pcl¹ has abdominal tergite 6 | male phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pcl¹ has abdominal tergite 4 | male phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pcl¹ has adult abdominal segment 7 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Scm^D1 has adult abdominal segment 4 phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4[+]/Hsc70-4^54.1 has abdominal tergite 6 | male phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Scm^D1 has adult abdominal segment 6 phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Scm^D1 has adult abdominal segment 5 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Scm^D1 has abdominal tergite 6 | male phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Scm^D1 has abdominal tergite 4 | male phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Scm^D1 has adult abdominal segment 7 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pc³ has wing phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pc³ has leg | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pc³ has abdominal tergite 1 phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pc³ has antenna phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pc³ has abdominal tergite 7 phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4[+]/Hsc70-4^54.1 has abdominal tergite 4 | male phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pc³ has haltere | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pc³ has adult abdominal segment 2 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pc³ has adult abdominal segment 8 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pcl¹ has adult abdominal segment 4 phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pcl¹ has adult abdominal segment 6 phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pcl¹ has adult abdominal segment 5 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pcl¹ has abdominal tergite 6 | male phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pcl¹ has abdominal tergite 4 | male phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4[+]/Hsc70-4^54.1 has adult abdominal segment 7 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pcl¹ has adult abdominal segment 7 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Scm^D1 has adult abdominal segment 4 phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Scm^D1 has adult abdominal segment 6 phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Scm^D1 has adult abdominal segment 5 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Scm^D1 has abdominal tergite 6 | male phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Scm^D1 has abdominal tergite 4 | male phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Scm^D1 has adult abdominal segment 7 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, ph-p⁴¹⁰ has arista phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, ph-p⁴¹⁰ has mesothoracic leg phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, ph-p⁴¹⁰ has metathoracic leg phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, ph-p⁴¹⁰ has adult thoracic sensillum phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, ph-p⁴¹⁰ has abdominal tergite phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, ph-p⁴¹⁰ has abdominal sternite phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pc³ has wing phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pc³ has leg | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, ph-p⁴¹⁰ has metathoracic leg phenotype

(Mollaaghababa et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

Flies carrying w^IR.GMR in which the eyes are homozygous for Hsc70-4^54.1 have small, rough eyes. There is no increase in eye pigmentation compared to w^IR.GMR single mutant flies.

(Zhou et al., 2008)

100% of Hsc70-4^54.1 Pc³ double heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 100% of Hsc70-4^54.1 Pc³ double heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). There is an average of 34 extra sex combs (average total number of extra sex comb teeth on the four posterior legs of a male) in Hsc70-4^54.1 Pc³ double heterozygotes. Transformation of the first abdominal tergite towards A2 segment identity is seen in Hsc70-4^54.1 Pc³ double heterozygotes. The seventh tergite and sternite are almost completely removed, partially transformed into A8. Patches of wing tissue are transformed to haltere. 50% of flies show partial antenna-to-leg transformations. The progeny of Hsc70-4^54.1 Pc³ double heterozygous females often die as first instar larvae, even when fathers are wild type, but Hsc70-4^54.1 Pc³ double heterozygous males give viable offspring when mated to wild-type females. 26% of Hsc70-4^54.1 Asx³ double heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 7% of Hsc70-4^54.1 Asx³ double heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). There is an average of 0.8 extra sex combs (average total number of extra sex comb teeth on the four posterior legs of a male) in Hsc70-4^54.1 Asx³ double heterozygotes. 70% of Hsc70-4^54.1 Pcl¹ double heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 35% of Hsc70-4^54.1 Pcl¹ double heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). There is an average of 1.6 extra sex combs (average total number of extra sex comb teeth on the four posterior legs of a male) in Hsc70-4^54.1 Pcl¹ double heterozygotes. 64% of Hsc70-4^54.1 Scm^D1 double heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 6% of Hsc70-4^54.1 Scm^D1 double heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). No extra sex combs are seen in Hsc70-4^54.1 Scm^D1 double heterozygotes. ph-p⁴¹⁰ Hsc70-4^54.1/+ males die as pharate adults with complete ectopic sex combs on the second and third thoracic legs. These animals show malformed or missing abdominal tergites and sternites, a reduced number of thoracic bristles, and missing aristae.

(Mollaaghababa et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

6398

ru¹ hry¹ Diap1^th-1 st¹ cu¹ Hsc70-4^54.1/TM6B, Tb⁺

Notes on Origin

Discoverer

Selected as: an enhancer of the Pc⁵ phenotype.

(Mollaaghababa et al., 2001)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsc70-4^54.1

(Swenson et al., 2016, Hennig et al., 2006)

hsc4^54.1

(Mollaaghababa et al., 2001)

hsc70-4^54.1

(Zhou et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (4)

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