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General Information
Symbol
Dmel\Asx3
Species
D. melanogaster
Name
FlyBase ID
FBal0000786
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
AsxXT129
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

1.3kb deletion. Resulting protein includes approximately the first 80-0 amino acids of the native protein.

1.3kb deletion.

1.2kb deletion in the middle of the coding region.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Asx3 embryos from heterozygous mothers show segregation defects in anaphase and telophase as judged by the presence of chromatin bridges. Most of these chromatin bridges are probably resolved because large irregularly-shaped nuclei and polyploid nuclei are only seen at a low penetrance. Asx3 embryos also show a higher level of "nuclear fallout", a process that removes nuclei with abnormal mitoses, than wild-type embryos. Fallout nuclei tend to be observed in pairs or clusters and have a late telophase appearance. There is no evidence of metaphase defects in these embryos although a small number show chromatin bridges that persist to the prometaphase stage.

Somatic mitotic clones of Asx3 do not induce ovarian defects.

10% of heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 0% of heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). There is an average of 0.1 extra sex combs (average total number of extra sex comb teeth on the four posterior legs of a male).

Embryonic lethal or semi-lethal when heterozygous with ph-d2. Unhatched larvae carry segmentation defects or polarity defects.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

Asx3/Asx[+] is an enhancer of visible | dominant | homeotic phenotype of brm[+]/brm2, trxE2

Asx3/Asx[+] is an enhancer of visible | dominant | homeotic phenotype of ash117, trxB11/trx[+]

Suppressor of
Statement
Reference

Asx3/Asx[+] is a suppressor of visible phenotype of tant2

Asx3/Asx[+] is a suppressor of visible phenotype of tant1

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

Asx3 has sex comb | ectopic phenotype, enhanceable by Hsc70-4[+]/Hsc70-454.1

Enhancer of
Statement
Reference

Asx3/Asx[+] is an enhancer of adult metathoracic segment phenotype of brm[+]/brm2, trxE2

Asx3/Asx[+] is an enhancer of adult metathoracic segment phenotype of ash117, trxB11/trx[+]

Asx3 is an enhancer of abdominal segment phenotype of Pc4

Asx3 is an enhancer of sex comb phenotype of Pc4

NOT Enhancer of
Statement
Reference

Asx3 is a non-enhancer of phenotype of trxB11

Suppressor of
Statement
Reference

Asx3/Asx[+] is a suppressor of interocellar bristle phenotype of tant2

Asx3/Asx[+] is a suppressor of interocellar bristle phenotype of tant1

NOT Suppressor of
Statement
Reference

Asx3 is a non-suppressor of phenotype of trxB11

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

26% of Hsc70-454.1 Asx3 double heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 7% of Hsc70-454.1 Asx3 double heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). There is an average of 0.8 extra sex combs (average total number of extra sex comb teeth on the four posterior legs of a male) in Hsc70-454.1 Asx3 double heterozygotes.

Does not significantly enhance the trx-G homeotic transformations of Df(3R)red1 or trxB11, nor suppress anterior transformations due to Df(3R)red1 or trxB11. Strongly enhances both the extra sex comb and abdominal segment transformation phenotypes of Pc4.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Weak derepression of en expression.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (17)