FlyBase Allele Report: Dmel\tant[2]

General Information

Symbol

Dmel\tant²

Species

D. melanogaster

Name

FlyBase ID

FBal0123680

Feature type

allele

Associated gene

Dmel\tant

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Dietrich et al., 2001)

Progenitor genotype

P{lacW}tant¹

(Dietrich et al., 2001)

Cytology

Description

Imprecise excision of the P{lacW} element resulting in a 1.4kb deletion that removes sequences in the 3' direction, deleting 266 of the 299 amino acid residues of tan.

(Dietrich et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Dietrich et al., 2001)

viable

(Dietrich et al., 2001)

visible (with Df(3L)CH4)

(Dietrich et al., 2001)

visible | recessive

(Dietrich et al., 2001)

Phenotype Manifest In

abdominal sternite bristle

(Dietrich et al., 2001)

abdominal sternite bristle | ectopic

(Dietrich et al., 2001)

abdominal tergite & macrochaeta

(Dietrich et al., 2001)

abdominal tergite & macrochaeta | ectopic

(Dietrich et al., 2001)

eye

(Dietrich et al., 2001)

interocellar bristle

(Dietrich et al., 2005, Dietrich et al., 2001)

interocellar bristle (with Df(3L)CH4)

(Dietrich et al., 2001)

interommatidial bristle

(Dietrich et al., 2001)

interommatidial bristle | increased number

(Dietrich et al., 2001)

macrochaeta | increased number

(Dietrich et al., 2001)

ommatidium

(Dietrich et al., 2001)

scutellar bristle | increased number

(Dietrich et al., 2001)

wing vein L5

(Dietrich et al., 2001)

Detailed Description

Statement

Reference

While tan² heterozygous adults are normal, 40% of tan² homozygotes have only five interocellar bristles, and 35% have four or fewer bristles (75% total with five or fewer bristles).

(Dietrich et al., 2005)

Homozygous adults have a rough eye due to ommatidial defects (including ommatidial fusions, smaller ommatidia than normal and deleted ommatidia) and deletion, misplacement or duplication of ommatidial bristles. The number of microchaetae between the ocelli is decreased from an average of 8 (+/- 2) in wild-type flies to an average of 5 (+/- 2) in homozygotes. Duplications of macrochaetae, predominantly the scutellar bristles (8% of flies) are seen and abdominal sternites and tergites occasionally have smaller, irregularly spaced and/or ectopic bristles. Wing vein L5 fails to reach the posterior wing margin in 85% of homozygotes.

(Dietrich et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

tant² has visible phenotype, enhanceable by Df(2R)trix/+

(Dietrich et al., 2001)

Suppressed by

Statement

Reference

tant² has visible phenotype, suppressible by Asx[+]/Asx¹⁵

(Dietrich et al., 2001)

tant² has visible phenotype, suppressible by Asx³/Asx[+]

(Dietrich et al., 2001)

tant² has visible phenotype, suppressible by Asx[+]/Asx⁹

(Dietrich et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

tant² has interocellar bristle phenotype, enhanceable by Df(2R)trix/+

(Dietrich et al., 2001)

Suppressed by

Statement

Reference

tant² has interocellar bristle phenotype, suppressible by Asx[+]/Asx¹⁵

(Dietrich et al., 2001)

tant² has interocellar bristle phenotype, suppressible by Asx³/Asx[+]

(Dietrich et al., 2001)

tant² has interocellar bristle phenotype, suppressible by Asx[+]/Asx⁹

(Dietrich et al., 2001)

Other

Statement

Reference

N^55e11, tant²/tan[+] has interocellar bristle phenotype

(Dietrich et al., 2005)

Df(1)N-8/+, tant² has interocellar bristle phenotype

(Dietrich et al., 2005)

N[+]/N^55e11, tant² has interocellar bristle phenotype

(Dietrich et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Df(1)N-8, when trans-heterozygous with the tan² allele, display a strong reduction in the number of interocellar bristles (74.7% with four or fewer bristles). Unlike either heterozygote tan²/+ N^55e11/+ mutants display a strong reduction in occellar bristle number.

The loss of interocellar bristles observed in Df(1)N-8/+; tan²/+ transheterozygotes can be partially rescued by a single copy of tan^t7 from 74.7% to 16.3% of flies exhibiting four or fewer interocellar bristles. The loss of interocellar bristles observed in N^55e11/+; tan²/+ transheterozygotes can be partially rescued by a single copy of tan^t7 from 26.7% to 4.1% of flies affected.

(Dietrich et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

tant² is partially rescued by tant^t7

(Dietrich et al., 2005)

tant² is partially rescued by tant^t7

(Dietrich et al., 2001)

Comments

The loss of interocellar bristles observed in Df(1)N-8/+; tan²/+ transheterozygotes can be rescued by a single copy of tan^t7 from 74.7% to 16.3% of flies exhibiting four or fewer interocellar bristles.

Expression of the tan<up>t7</up> partially rescues the tan²/+, Df(1)N-8/+ and tan²/+, N^55e11/+ double mutant bristle phenotypes. The phenotypes are not seen in tan²/+, Df(1)N-8/+ or N^55e11/+ single mutant heterozygotes.

(Dietrich et al., 2005)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

tan²

tant²

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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