FlyBase Allele Report: Dmel\tant[t7]

General Information

Symbol

Dmel\tant^t7

Species

D. melanogaster

Name

FlyBase ID

FBal0123675

Feature type

allele

Associated gene

Dmel\tant

Associated Insertion(s)

Carried in Construct

P{tant^t7}

Key Links

Transgenic product class

genomic_DNA

(Dietrich et al., 2001)

wild_type

(Dietrich et al., 2001)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

genomic_DNA

(Dietrich et al., 2001)

wild_type

(Dietrich et al., 2001)

Mutagen

in vitro construct

(Dietrich et al., 2001)

Progenitor genotype

Carried in construct

P{tant^t7}

Cytology

Description

Approximately 7kb tant genomic fragment 1477bp of upstream and 3kb of downstream sequences.

(Dietrich et al., 2001)

Allele components

Component

Use(s)

Regulatory region(s)

tant

Encoded product / tool

tant

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Dietrich et al., 2001)

visible

(Dietrich et al., 2001)

Phenotype Manifest In

postocellar bristle

(Dietrich et al., 2001)

Detailed Description

Statement

Reference

Flies carrying two copies of tan^t7 in a wild-type background have defects in a variety of sensory tissues. Defects in the postvertical bristles include deletions, deletions with sockets remaining and reductions in size.

(Dietrich et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The effect of bristle number reduction, as seen in the N^55e11/+; tan²/+ transheterozygotes can be alleviated by providing a single copy of tan^t7. The loss of interocellar bristles observed in Df(1)N-8/+; tan²/+ transheterozygotes can be rescued by a single copy of tan^t7 from 74.7% to 16.3% of flies exhibiting four or fewer interocellar bristles.

The effect of bristle number reduction, as seen in the N^55e11/+; tan²/+ transheterozygotes can be alleviated by providing a single copy of tan^t7.

The loss of interocellar bristles observed in Df(1)N-8/+; tan²/+ transheterozygotes can be rescued by a single copy of tan^t7 from 74.7% to 16.3% of flies exhibiting four or fewer interocellar bristles.

The loss of interocellar bristles observed in Df(1)N-8/+; tan²/+ transheterozygotes can be partially rescued by a single copy of tan^t7 from 74.7% to 16.3% of flies exhibiting four or fewer interocellar bristles. The loss of interocellar bristles observed in N^55e11/+; tan²/+ transheterozygotes can be partially rescued by a single copy of tan^t7 from 26.7% to 4.1% of flies affected.

(Dietrich et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

tant^t7 partially rescues tant²

(Dietrich et al., 2005)

tant^t7 partially rescues tant²

(Dietrich et al., 2001)

Comments

Expression of the tan<up>t7</up> partially rescues the tan²/+, Df(1)N-8/+ and tan²/+, N^55e11/+ double mutant bristle phenotypes. The phenotypes are not seen in tan²/+, Df(1)N-8/+ or N^55e11/+ single mutant heterozygotes.

(Dietrich et al., 2005)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

P[tan]

(Dietrich et al., 2005)

tan^t7

tant^t7

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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