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General Information
Symbol
Dmel\DlM1
Species
D. melanogaster
Name
FlyBase ID
FBal0029360
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
DeltaM1
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Clones of homozygous DlM1 mutant ovarian follicle cells tend to have larger nuclei than surrounding wild-type cells.

Homozygous mutant germ-line clones produces severe encapsulation defects leading to the fusion of adjacent egg chambers into a single large compound egg chamber that contains multiple germ-line cysts. When germ cells of an single egg chamber are made mutant for DlM1 (by germ-line clone induction), the wild-type follicle cells that surround them continue to divide well beyond stage 6. These egg chambers show a strong and highly penetrant oocyte polarity defect, as the oocyte nucleus remains at the posterior pole of the cell almost all cases. Individual egg chambers bearing mutant germ-line clones usually fuse with an adjacent wild-type one to form a mosaic egg chamber in which a single follicular epithelium surrounds both wild-type and mutant germ-cells. The anterior posterior axis is also not polarised in these egg chambers. Homozygous mutant somatic clones in the follicle cells leads to occasional partial fusions between the adjacent egg chambers. The cysts are still surrounded by follicle cells, but the stalk between them is completely absent. No other obvious defects are seen.

Heterozygotes show thickening of the wing veins, mainly in the distal part of the veins.

Wing veins L2 and L5 are irregularly broader than wild-type veins in heterozygous flies, with the effect being most obvious at the distal tips of the veins.

Wing veins are thickened.

Homozygous clones in the tarsi result in fusion between tarsal segments. The remnants of some joints are still recognisable.

Mitotic clones in the dorsal LIII and ventral LIV wing veins induce vein differentiation in the adjacent one or two wild type cells. Clones induced in a rhove-1 vn1 mutant background differentiate extra-sensilla associated with the remnants of the vein, most cells in the clone differentiate as intervein cells.

Homozygous clones including dorsal and ventral clones cause extensive wing scalloping. Clones in the ventral compartment cause small nicks or loss of margin sensory elements. Clones in the dorsal compartment cause only loss of sensory elements.

Dominant increase-in-chaetae-density phenotype.

Dominant by haplo-insufficiency causing notum phenotypes of evenly spaced macrochaetae.

Heterozygote have thickened veins and terminal deltas.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

DlM1 has visible | dominant phenotype, suppressible by N[+]/N55e11

Enhancer of
Statement
Reference

DlM1/Dl[+] is an enhancer of visible | dominant phenotype of amosTft

DlM1/Dl[+] is an enhancer of visible | somatic clone phenotype of emc1

Suppressor of
Statement
Reference

DlM1/Dl[+] is a suppressor of visible | dominant phenotype of N55e11

Phenotype Manifest In
Enhanced by
Statement
Reference

DlM1 has phenotype, enhanceable by bs03267

Suppressed by
Statement
Reference

DlM1 has wing phenotype, suppressible by N[+]/N55e11

DlM1 has wing vein phenotype, suppressible by N[+]/N55e11

Enhancer of
Statement
Reference

DlM1/Dl[+] is an enhancer of macrochaeta | ectopic phenotype of amosTft

DlM1/Dl[+] is an enhancer of wing vein | somatic clone phenotype of emc1

Suppressor of
Statement
Reference

DlM1/Dl[+] is a suppressor of wing phenotype of N55e11

DlM1/Dl[+] is a suppressor of wing vein phenotype of N55e11

DlM1/Dl[+] is a suppressor of phenotype of Egfrt1/Egfrf11

Additional Comments
Genetic Interactions
Statement
Reference

The average number of ectopic macrochaetae per heminotum in amosTft/+ flies is increased to 33 +/- 5 if they are also carrying DlM1/+.

The wing veins and margin are normal in N55e11/+ ; DlM1/+ double heterozygotes. Enhances the wing phenotype of Dp(1;2)51b flies.

DlM1/+ EgfrE3/+ flies show a simple additive phenotype. Egfrt1/Egfrf11 shows a negative interaction in combination with DlM1/+.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

See de Celis et al. 1992, Roux's Arch Dev Biol 200:64-76 and Diaz-Benjumea and Garcia Bellido 1990, Roux's Arch Dev Biol 198:336--354 .

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (18)