Gene model reviewed during 5.40
Gene model reviewed during 5.46
There is only one protein coding transcript and one polypeptide associated with this gene
81 (aa); 9 (kD)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Brd using the Feature Mapper tool.
Brd transcripts are detected in third instar larval eye discs in the morphogenetic furrow in closely spaced stripes, one anterior to the stripe of dpp staining in the furrow and one within the furrow and posterior to it. They are detected in the pupal wing at 8h APF in large clusters of proximal campaniform sensilla.
Brd transcripts are detected weakly in preblastoderm embryos, are abundant in 4-8hr embryos and drop off dramatically in later embryonic stages on northern blots. Brd is expressed specifically in proneural clusters in the imaginal discs. In the wing imaginal disc, it is present at the positions of all developing adult external sensory organs. Further, it was found that Brd expression precedes sensory organ precursor specification.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Brd in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Brd CG3096
Possibly "Hi" was a "Brd" allele.
Candidate gene for quantitative trait (QTL) locus determining bristle number.
The Brd 3' UTR confers negative regulatory activity on heterologous reporter genes in vivo.
Electrophoretic mobility shift assays demonstrate that Brd is directly activated in proneural clusters of the late third-instar wing imaginal disc by protein complexes that include the ac and sc bHLH proteins.
Mutations of Brd cause either sensory organ multiplication or loss. Cell markers reveal that multiplication results from the determination of supernumerary precursor cells and loss from the inappropriate differentiation of all precursor cells as neurons.
Causes production of supernumerary chaetae and sensilla at or near normal positions. Brd alleles affect all classes of adult sensory organs. The combination of sensilla multiplication and loss phenotypes is made more severe by loss-of-function mutations at N and neur and are decreased in the presence of three wild-type copies of these genes.