FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Brd1
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General Information
Symbol
Dmel\Brd1
Species
D. melanogaster
Name
FlyBase ID
FBal0001270
Feature type
allele
Associated gene
Dmel\Brd
Associated Insertion(s)
blood{}Brd-1
Carried in Construct
Key Links
Genomic Maps

Allele class

hypermorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypermorphic allele - genetic evidence

(Leviten and Posakony, 1996)
Mutagen
spontaneous
(Leviten and Posakony, 1996)
Progenitor genotype
Associated Insertion(s)
blood{}Brd-1
Cytology
Description

Insertion of a blood element in the 3' untranslated region, at position +399.

(Leviten et al., 1997)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Bristle multiplication phenotype, ectopic bristles are complete sensory organs. Anterior orbital, ocellar and posterior supra-alar bristle loss due to defects in the cell fate specification in the bristle lineage.

      (Leviten and Posakony, 1996)

      Brd1 homozygotes survive and exhibit more severe phenotypes than heterozygotes. Brd1/+ = Brd1 hemizygous with Brd-. Brd1 strongly affects macrochaetae and other imaginal-disc sensilla (i.e., trichoid, campaniform, basiconic), but only mildly increases microchaete density. In addition to sensillum multiplication, Brd1 homozygotes also exhibit bristle loss, with anterior orbitals absent (>90%) and a less frequent loss of ocellar macrochaetae (<5%).The EMS-induced point revertants of Brd1 tested (Brdrv1 to Brdrv4) are homozygous viable, viable in trans to Brd deficiencies and display no mutant phenotypes in either situation.

      (Lindsley and Zimm, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Brd1 is an enhancer of decreased size | adult stage phenotype of Scer\GAL4ey.200.Exel, fngUAS.cKa

      (Lee et al., 2025)

      Brd1 is an enhancer of decreased size | larval stage phenotype of Scer\GAL4ey.200.Exel, fngUAS.cKa

      (Lee et al., 2025)

      Brd[+]/Brd1 is an enhancer of visible phenotype of Df(1)os1

      (Mukherjee et al., 2006)

      Brd[+]/Brd1 is an enhancer of visible | dominant phenotype of amosTft

      (Lai, 2003)
      Suppressor of
      Statement
      Reference

      Brd[+]/Brd1 is a suppressor of visible phenotype of upd1GMR.PB

      (Mukherjee et al., 2006)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Brd1 has phenotype, enhanceable by Dns1

      (Leviten and Posakony, 1996)

      Brd1 has phenotype, enhanceable by DeltaCS20

      (Leviten and Posakony, 1996)

      Brd1 has phenotype, enhanceable by E(Brd)M101

      (Leviten and Posakony, 1996)

      Brd1 has phenotype, enhanceable by N55e11

      (Leviten and Posakony, 1996)

      Brd1 has phenotype, enhanceable by neur11

      (Leviten and Posakony, 1996)

      Brd1 has phenotype, enhanceable by neur1

      (Leviten and Posakony, 1996)

      Brd1 has phenotype, enhanceable by neurA101

      (Leviten and Posakony, 1996)

      Brd1 has phenotype, enhanceable by neurIP-1

      (Leviten and Posakony, 1996)
      Suppressed by
      Statement
      Reference

      Brd1 has phenotype, suppressible by H21

      (Bang et al., 1991)
      Enhancer of
      Statement
      Reference

      Brd1 is an enhancer of eye phenotype of Scer\GAL4ey.200.Exel, fngUAS.cKa

      (Lee et al., 2025)

      Brd1 is an enhancer of eye disc | larval stage phenotype of Scer\GAL4ey.200.Exel, fngUAS.cKa

      (Lee et al., 2025)

      Brd[+]/Brd1 is an enhancer of eye phenotype of Df(1)os1

      (Mukherjee et al., 2006)

      Brd[+]/Brd1 is an enhancer of macrochaeta | ectopic phenotype of amosTft

      (Lai, 2003)

      Brd1 is an enhancer of phenotype of Dns1

      (Leviten and Posakony, 1996)
      Suppressor of
      Statement
      Reference

      Brd[+]/Brd1 is a suppressor of eye phenotype of upd1GMR.PB

      (Mukherjee et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The amosTft/+ phenotype ectopic bristle phenotype is enhanced by Brd1/+.

      (Lai, 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (1)
      Stocks (0)
      Notes on Origin
      Discoverer

      Groger.

      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      1
      (Mukherjee et al., 2006)
      Brd1
      (Lee et al., 2025)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)