The increased number of intestinal progenitor cells in mitosis characteristic for adult flies expressing RetScer\UAS.T:Zzzz\FLAG,T:Zzzz\His6 driven by Scer\GAL4esg-NP7397 (combined with tub-Gal80[ts] for temporal control) is suppressed by co-expression of FakScer\UAS.T:Ivir\HA1.
Heterozygous FakCG1 enhances the ommatidial mis-patterning seen in eyes expressing RetGMR.PR. Homozygous FakCG1 causes a smaller eye due to a completely disrupted ommatidial pattern. This enhancement is reversed upon co-expression of either FakScer\UAS.T:Ivir\HA1 or FakY430F.Scer\UAS under the control of Scer\GAL4GMR.PU.
Expression of RetGMR.PR partially suppresses the reduction in eye size seen in flies expressing hidGMR.PG. This suppression is partially reversed when FakScer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4GMR.PU.
Expression of FakScer\UAS.T:Ivir\HA1 suppresses the partial lethality seen when RetMEN2A.Scer\UAS is expressed under the control of Scer\GAL4ptc-559.1. The proportion of surviving flies rises from 46% to 92%. The wing vein and male genitalia defects seen in adult flies are also suppressed.
Expression of FakScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU partially suppresses the eye size defect and ectopic cone cell phenotype induced by expression of two copies of RetMEN2A.GMR, resulting in the reappearance of normal ommatidial cores and surrounding interommatidial cells in pupal retinas.
Expression of FakScer\UAS.T:Ivir\HA1 partially suppresses the almost total lethality seen when EgfrScer\UAS.cBa is expressed under the control of Scer\GAL4ptc-559.1. The proportion of surviving flies is increased to approximately 60%.
The defects seen in the Fas2-positive longitudinal fascicles of embryos expressing FakScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4sca-537.4 are partially suppressed if the embryos are also heterozygous for Sema-1ak13702.
The penetrance of the wing blistering phenotype seen in females expressing Fak56DScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4en-e16E at 25oC is increased from 28% to 44% and 40% if they are carrying mys8/+ or mysb43/+ respectively. Males expressing Fak56DScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4en-e16E at 25oC and hemizygous for either mys8 or mysb43 show 31% and 21% wing blistering respectively (compared to 0% wing blistering in a mys+ background).
The inhibition of border cell migration seen in the ovaries of jara.Scer\UAS; Scer\GAL4slbo.2.6 flies is significantly suppressed by the presence of shghs.PW under heat shock condition (flies raised at 29oC and given a 1 hour heat shock at 37oC 6-10 hours prior to dissection.). Partial suppression is also seen in flies carrying slboScer\UAS.cLa or shgScer\UAS.cSa, but not Fak56DScer\UAS.T:Ivir\HA1.
The neuromuscular junction defects seen in FakN30/FakK24 larvae are rescued by expression of FakScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4elav.PU, but not under the control of Scer\GAL4Mhc.PW.
The optic stalk defects of Fak56DCG1 homozygotes are rescued by expression of Fak56DScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4NP4702, partially rescued by expression of Fak56DScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4NP2109 and are not rescued by expression of Fak56DScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PY.