FlyBase Allele Report: Dmel\Pp1-87B[1]

General Information

Symbol

Dmel\Pp1-87B¹

Species

D. melanogaster

Name

FlyBase ID

FBal0013933

Feature type

allele

Associated gene

Dmel\Pp1-87B

Associated Insertion(s)

Carried in Construct

Also Known As

PP1α87B¹, Su(var)3-6⁰¹, Su(var)3-6¹, Su-var(3)6⁰¹

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Swanhart et al., 2007, Wustmann and Spatz, 1993)

Mutagen

ethyl methanesulfonate

(Reuter et al., 1986)

Progenitor genotype

Cytology

Polytene chromosomes normal.

Description

Amino acid replacement: G220S.

(Dombradi and Cohen, 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:12,425,031..12,425,031 [-]

Nucleotide change:

G12425031A

Amino acid change:

G220S | Pp1-87B-PA

Reported amino acid change:

G220S

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Dombradi and Cohen, 1992)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Pp1-87B¹ heterozygous embryos appear wild-type and hatch normally.

(Tan et al., 2008)

Pp1-87B¹/Pp1-87B^87Bg-3 animals die during pupariation, and until pupariation, do not lag behind in development compared to their control siblings.

(Kirchner et al., 2007)

Homozygotes and heterozygotes show no muscle detachment or indirect flight muscle phenotypes.

(Raghavan et al., 2000)

Suppresses the position effect variegation at the w locus caused by In(1)w^m4 and suppresses the position effect variegation at the bw locus caused by In(2R)bw^VDe2 and Byron. Also suppresses the position effect variegation of w seen in the P{wA^R}41A insertion.

(Sass and Henikoff, 1998)

Strong suppressor levels of position effect vareigation and normal mitosis in neuroblasts or ganglion mother cells.

(Baksa et al., 1993)

Dominant suppressor of position effect variegation at the w locus caused by In(1)w^m4h.

(Reuter et al., 1986)

shows some reduction in viability in trans heterozygotes with some alleles of l(3)87Bg; in one case a clear maternal effect is noted.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Pp1-87B^87Bg-3/Pp1-87B¹ has lethal phenotype, suppressible by Scer\GAL4^arm.PS/Pp1α-96A^UAS.Tag:HA

(Kirchner et al., 2007)

Pp1-87B^87Bg-3/Pp1-87B¹ has lethal phenotype, suppressible by flw^UAS.Tag:HA/Scer\GAL4^arm.PS

(Kirchner et al., 2007)

NOT suppressed by

Statement

Reference

Pp1α-96A², Pp1-87B^87Bg-3/Pp1-87B¹ has lethal phenotype, non-suppressible by flw^UAS.Tag:HA/Scer\GAL4^arm.PS

(Kirchner et al., 2007)

Enhancer of

Statement

Reference

Pp1-87B¹ is an enhancer of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

Pp1-87B¹ is an enhancer of visible phenotype of Ret^GMR.PR

(Read et al., 2005)

Pp1-87B[+]/Pp1-87B¹ is an enhancer of visible phenotype of Scer\GAL4^vg.PM, put^UAS.cMa

(Bennett et al., 2003)

NOT Enhancer of

Statement

Reference

Pp1-87B¹ is a non-enhancer of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

Suppressor of

Statement

Reference

Pp1-87B[+]/Pp1-87B¹ is a suppressor | partially of visible | homeotic phenotype of trx^E2/trx¹

(Rudenko et al., 2003)

Pp1-87B[+]/Pp1-87B¹ is a suppressor | partially of visible | homeotic phenotype of trx^B11/trx¹

(Rudenko et al., 2003)

NOT Suppressor of

Statement

Reference

Pp1-87B¹ is a non-suppressor of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

Other

Statement

Reference

Pp1-87B¹, mars¹ has lethal | embryonic stage phenotype

(Tan et al., 2008)

Pp1-87B¹, mars¹ has abnormal hatching behavior phenotype

(Tan et al., 2008)

NiPp1^UAS.EGFP, Pp1-87B¹, Scer\GAL4^vg.PM has visible phenotype

(Parker et al., 2002)

Phenotype Manifest In

Enhancer of

Statement

Reference

Pp1-87B[+]/Pp1-87B¹ is an enhancer of posterior wing margin phenotype of Nop17l^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^Bx-MS1096

(Bennett et al., 2006)

Pp1-87B[+]/Pp1-87B¹ is an enhancer of wing phenotype of Nop17l^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^Bx-MS1096

(Bennett et al., 2006)

Pp1-87B¹ is an enhancer of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

Pp1-87B¹ is an enhancer of eye phenotype of Ret^GMR.PR

(Read et al., 2005)

Pp1-87B[+]/Pp1-87B¹ is an enhancer of wing phenotype of Scer\GAL4^vg.PM, put^UAS.cMa

(Bennett et al., 2003)

Pp1-87B[+]/Pp1-87B¹ is an enhancer of wing blade posterior compartment phenotype of Scer\GAL4^vg.int2.1, put^UAS.cMa

(Bennett and Alphey, 2002)

NOT Enhancer of

Statement

Reference

Pp1-87B¹ is a non-enhancer of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

Suppressor of

Statement

Reference

Pp1-87B[+]/Pp1-87B¹ is a suppressor | partially of haltere | ectopic phenotype of trx^B11/trx¹

(Rudenko et al., 2003)

Pp1-87B[+]/Pp1-87B¹ is a suppressor | partially of wing phenotype of trx^E2/trx¹

(Rudenko et al., 2003)

Pp1-87B[+]/Pp1-87B¹ is a suppressor | partially of haltere | ectopic phenotype of trx^E2/trx¹

(Rudenko et al., 2003)

Pp1-87B[+]/Pp1-87B¹ is a suppressor | partially of wing phenotype of trx^B11/trx¹

(Rudenko et al., 2003)

NOT Suppressor of

Statement

Reference

Pp1-87B¹ is a non-suppressor of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

Other

Statement

Reference

NiPp1^UAS.EGFP, Pp1-87B¹, Scer\GAL4^vg.PM has wing phenotype

(Parker et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Embryos laid by flies heterozygous for mars¹ and Pp1-87B¹ show a significantly reduced hatch ratio.

(Tan et al., 2008)

Pp1-87B¹/Pp1-87B^87Bg-3 Pp1α-96A²/Pp1α-96A² double mutant animals die slightly earlier than Pp1-87B¹/Pp1-87B^87Bg-3 single mutants and pupariate 1-2 days later than their siblings.

(Kirchner et al., 2007)

Expression of Nop17l^{Scer\UAS.T:Zzzz\His6,T:Hsap\MYC} under the control of Scer\GAL4^Bx-MS1096 in Pp1-87B¹/+ wings results in severely crumpled and reduced wings.

(Bennett et al., 2006)

The modest wing overgrowth phenotype caused by expression of put^Scer\UAS.cMa under the control of Scer\GAL4^vg.PM is enhanced by Pp1-87B¹/+.

(Bennett et al., 2003)

Pp1-87B¹ dominantly suppresses the transformation of wing to haltere seen in trx¹/trx^E2 flies; 31% show strong transformation, 39% show weak transformation and 30% show no transformation.

Pp1-87B¹ dominantly suppresses the transformation of wing to haltere seen in trx¹/trx^B11 flies; 27% show strong transformation, 24% show weak transformation and 49% show no transformation.

(Rudenko et al., 2003)

Flies expressing NiPp1^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^vg.PM which are also carrying Pp1-87B¹ have crumpled wings.

(Parker et al., 2002)

The effect of loss of one copy of Pp1-87B¹ cannot be rescued by P element mediated transformation with Su(var)3-7.

(Reuter et al., 1990)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Pp1-87B^87Bg-3/Pp1-87B¹ is rescued by Pp1-87B^UAS.Tag:HA/Scer\GAL4^arm.PS

(Kirchner et al., 2007)

Pp1-87B¹ is rescued by Pp1-87B^+t5.8

(Baksa et al., 1993)

Comments

The suppressor phenotype of Pp1-87B¹ on In(1)w^m4h is rescued by Pp1-87B^+t5.8. The lethality of Pp1-87B¹ is rescued by Pp1-87B^+t5.8.

(Baksa et al., 1993)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Not suppressed by zip alleles.

(Vereshchagina et al., 2004)

Isolated as a suppressor of position effect variegation at the w locus in flies carrying In(1)w^m4h, and a dominant enhancer of position effect variegation, E(var)c101¹.

(Reuter et al., 1986)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

PP1α87B¹

(Moura et al., 2025, Kirchner et al., 2007, Swanhart et al., 2007, Bennett et al., 2006, Vereshchagina et al., 2004, Bennett et al., 2003, Rudenko et al., 2003, Parker et al., 2002)

Pp1-87^B1

(Read et al., 2005)

Pp1-87B¹

(Christensen et al., 2009.7.22, Cook et al., 2009.2.28, Tan et al., 2008, Geng and MacDonald, 2007)

Pp1-87B^Suvar(3)6-01

(Bennett and Alphey, 2002)

Su(var)3-6⁰¹

(Abramov et al., 2016, Erhardt et al., 2003, Hwang et al., 2001, Balasov et al., 2000, Gvozdev et al., 2000, Naumova et al., 2000, Sass and Henikoff, 1998)

Su(var)3-6¹

(Kurenova et al., 1998, Reuter et al., 1990, Reuter et al., 1987)

Su-var(3)6

(Dombradi and Cohen, 1992)

Su-var(3)6⁰¹

(Riedel, 1999, Baksa et al., 1993, Wustmann and Spatz, 1993, Reuter et al., 1986)

Name Synonyms

Secondary FlyBase IDs

References (31)

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