FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mars1
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General Information
Symbol
Dmel\mars1
Species
D. melanogaster
Name
FlyBase ID
FBal0243582
Feature type
allele
Associated gene
Dmel\mars
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Tan et al., 2008)
Progenitor genotype
marsEP2477
(Tan et al., 2008)
Cytology
Description

Imprecise excision of P{EP}drkEP2477 generates a 0.84kb deletion that removes the mars initiation codon and part of the coding region.

(Tan et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2R:13,503,019..13,503,870 [+]
Comment:

852bp deletion resulting from imprecise excision of P{EP}drkEP2477. 7 bases inserted at deletion site.

Inserted_sequence:

GATGAAA

(Tan et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous oocytes show defects in spindle morphology: microtubules often fail to be properly tapered at the spindle poles.

      (Cesario and McKim, 2011)

      Eggs laid by mars1 and mars1/marsEP2477 flies show a greatly reduced ability to hatch. Sperm tails can be visualised in early-arrested embryos laid by mutant females, indicating that sterility is caused by arrest in embryogenesis after fertilization.

      mars1 embryos, lacking maternal mars arrest during early embryogenesis after no more than five nuclear divisions. Approximately 82% of 15-45 minute old embryos laid by mars1 mothers exhibit at least two discrete DNA-containing regions, the first, localized to the embryonic cortext, resembling a polar body; and the second, surrounded by a bipolar spindle, is more central, indicating that the vast majority of mutant embryos pass though meiosis to form one or more mitotic figure.

      The spindle structures in mars1 mutant embryos are very small and weak, albeit sill bipolar. Most exhibit at least one detached centrosome. Unaligned chromosomes are also found.

      Embryos laid by mars1/marsEP2477 mothers resemble those from mars1 mothers, with less severe phenotypes.

      mars1 heterozygous embryos appear wild-type and hatch normally.

      (Tan et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      mars1/marsEP2477 has lethal | embryonic stage phenotype, suppressible by taccS863L.Ubi-p63E.GFP

      (Tan et al., 2008)
      NOT suppressed by
      Statement
      Reference

      mars1/marsEP2477 has lethal | embryonic stage phenotype, non-suppressible by taccUbi-p63E.GFP

      (Tan et al., 2008)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Embryos laid by flies heterozygous for mars1 and Pp1-87B1 show a significantly reduced hatch ratio.

      The lethality of embryos laid by mars1/marsEP2477 mothers is rescued by taccS863L.Ubi-p63E.T:Avic\GFP but not taccUbi-p63E.T:Avic\GFP expression.

      (Tan et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      mars1/marsEP2477 is rescued by marsUASp.cTa

      (Tan et al., 2008)

      mars1 is rescued by marsUASp.cTa

      (Tan et al., 2008)
      Not rescued by

      mars1/marsEP2477 is not rescued by marsF839A.UASp/Scer\GAL4arm.PS

      (Tan et al., 2008)

      mars1 is not rescued by marsF839A.UASp/Scer\GAL4arm.PS

      (Tan et al., 2008)
      Comments

      Expression of marsScer\UAS.P\T.cTa in the female germline, under the control of Scer\GAL4arm.PS restores embryo viability and fertility in mars1 and mars1/marsEP2477 mutants.

      Ectopic expression of marsF839A.Scer\UAS.P\T under the control of Scer\GAL4arm.PS fails to rescue the embryonic lethality of embryos laid by mars1 or mars1/marsEP2477 mothers.

      (Tan et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mars1
      (Cesario and McKim, 2011, Tan et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)