FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\taccS863L.Ubi-p63E.GFP
Open Close
General Information
Symbol
Dmel\taccS863L.Ubi-p63E.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0212146
Feature type
allele
Associated gene
Dmel\tacc
Associated Insertion(s)
Carried in Construct
P{Ubi-GFP-tacc.S863L}
Key Links
Transgenic product class
missense_variant
(Barros et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Barros et al., 2005)
Mutagen
in vitro construct
(Barros et al., 2005)
Progenitor genotype
taccUbi-p63E.GFP
(Barros et al., 2005)
Carried in construct
P{Ubi-GFP-tacc.S863L}
Cytology
Description

Amino acid replacement: S863L.

(Barros et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
Ubi-p63E
Encoded product / tool
tacc
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Astral microtubules are detectable at any stage of the cell cycle in taccS863L.Ubi-p63E.T:Avic\GFP embryos, including anaphase, although spindle microtubules appear to be relatively normal. The mean spindle length in taccS863L.Ubi-p63E.T:Avic\GFP embryos is 13.2 υm, approximately 10% shorter than the mean length in wild-type embryos.

      (Barros et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      taccS863L.Ubi-p63E.GFP is a suppressor of lethal | embryonic stage phenotype of mars1/marsEP2477

      (Tan et al., 2008)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The lethality of embryos laid by mars1/marsEP2477 mothers is rescued by taccS863L.Ubi-p63E.T:Avic\GFP expression.

      (Tan et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      taccS863L.Ubi-p63E.GFP partially rescues taccstella592

      (Barros et al., 2005)
      Comments

      Expression of taccS863L.Ubi-p63E.T:Avic\GFP in a taccstella592 mutant background results in approximately 30% viability, with those embryos that do develop exhibiting a high incidence of mitotic defects, suggesting only partial rescue.

      (Barros et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      taccS863L.Ubi-p63E.GFP
      taccS863L.Ubi-p63E.T:Avic\GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (4)