FlyBase Allele Report: Dmel\ksr[j5E2]

General Information

Symbol

Dmel\ksr^j5E2

Species

D. melanogaster

Name

FlyBase ID

FBal0010976

Feature type

allele

Associated gene

Dmel\ksr

Associated Insertion(s)

P{lacW}ksr^j5E2

Carried in Construct

Also Known As

J5E2

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{lacW}ksr^j5E2

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:5,517,156..5,517,156 [+]

(Dworkin and Gibson, 2006, Spradling et al., 1999, Therrien et al., 1995, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Dworkin and Gibson, 2006, Spradling et al., 1999, BDGP Project Members, 1994-1999)

visible | dominant

(Dworkin and Gibson, 2006)

Phenotype Manifest In

wing

(Dworkin and Gibson, 2006)

Detailed Description

Statement

Reference

Heterozygotes show a direct effect on the shape of the wing.

(Dworkin and Gibson, 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

ksr^j5E2/ksr[+] is a suppressor of visible phenotype of Hsap\MAPT^UAS.S11A, Scer\GAL4^GMR.PS

(Ambegaokar and Jackson, 2011)

ksr^j5E2/ksr[+] is a suppressor | partially of visible phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PS

(Ambegaokar and Jackson, 2011)

ksr^j5E2/ksr[+] is a suppressor of visible phenotype of Hsap\TARDBP^{Q331K.UAS.cLa}, Scer\GAL4^GMR.PS

(Ambegaokar and Jackson, 2011)

ksr^j5E2/ksr[+] is a suppressor of visible phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

ksr^j5E2 is a suppressor of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

ksr^j5E2 is a suppressor of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

ksr^j5E2 is a suppressor of visible phenotype of Ret^GMR.PR

(Read et al., 2005)

NOT Suppressor of

Statement

Reference

ksr^j5E2/ksr[+] is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

ksr^j5E2/ksr[+] is a non-suppressor | partially of visible phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PS

(Ambegaokar and Jackson, 2011)

Phenotype Manifest In

Suppressor of

Statement

Reference

ksr^j5E2/ksr[+] is a suppressor of eye phenotype of Hsap\MAPT^UAS.S11A, Scer\GAL4^GMR.PS

(Ambegaokar and Jackson, 2011)

ksr^j5E2/ksr[+] is a suppressor | partially of eye phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PS

(Ambegaokar and Jackson, 2011)

ksr^j5E2/ksr[+] is a suppressor of eye phenotype of Hsap\TARDBP^{Q331K.UAS.cLa}, Scer\GAL4^GMR.PS

(Ambegaokar and Jackson, 2011)

ksr^j5E2/ksr[+] is a suppressor of eye phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

ksr^j5E2 is a suppressor of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

ksr^j5E2 is a suppressor of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

ksr^j5E2 is a suppressor of eye phenotype of Ret^GMR.PR

(Read et al., 2005)

NOT Suppressor of

Statement

Reference

ksr^j5E2/ksr[+] is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

ksr^j5E2/ksr[+] is a non-suppressor | partially of eye phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PS

(Ambegaokar and Jackson, 2011)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of ksr^j5E2 does not suppress the apoptosis seen in flies overexpressing hid.

(Ambegaokar and Jackson, 2011)

Xenogenetic Interactions

Statement

Reference

One copy of ksr^j5E2 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of ksr^j5E2 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^{Scer\UAS.S11A} under the control of Scer\GAL4^GMR.PS.

ksr^j5E2 mildly suppresses the eye phenotype seen in flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^GMR.PS.

ksr^j5E2 suppresses the eye phenotype seen in flies expressing Hsap\TARDBP^{Q331K.Scer\UAS.cLa} under the control of Scer\GAL4^GMR.PS.

One copy of ksr^j5E2 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

(Ambegaokar and Jackson, 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

10212

w¹¹¹⁸; P{lacW}ksr^j5E2/TM3, P{ftz-lacC}SC1, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

L. and Y. Jan.

Comments

Complements: Snr1⁰¹³¹⁹. Complements: l(3)03644⁰³⁶⁴⁴. Complements: Itp-r83A⁰⁵⁶¹⁶. Complements: Itp-r83A^j5B4. Fails to complement: Itp-r83A^L2262b.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

J5E2

(Dworkin et al., 2011, Dworkin and Gibson, 2006)

ksr^J5E2

(Dworkin and Gibson., 2006)

ksr^j5E2

(Ambegaokar and Jackson, 2011)

l(3)j5E2

(Spradling et al., 1999)

l(3)j5E2^j5E2

(Therrien et al., 1995, BDGP Project Members, 1994-1999)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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