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General Information
Symbol
Zzzz\CAGQ108.UAS
Species
a. artificial
Name
FlyBase ID
FBal0137334
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Q108, UAS-108Q
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a 108 amino acid polyglutamine repeat (the repeat is flanked by the amino acid sequence MRSRKL at the N-terminal end and by KLRS at the C-terminal end).

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PF results in rough eyes which show loss of pigmentation. The internal structure of the retina is disrupted and contains large vacuoles.

1 week old flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4ninaE.PT show no degeneration of photoreceptors. However, by 4 weeks of age, the flies show degeneration of photoreceptor neurons and the rhabdomeres are fragmented.

Animals expressing Zzzz\CAGQ108.Scer\UAS driven by Scer\GAL4179Y or Scer\GAL4Appl.G1a exhibit aa severe sluggish larval movement phenotype.

Adult survivors expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PF have a rough eye with no pigment.

Pharate adults expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4dpp.blk1 are missing entire third legs, have defects in head capsule evagination and development of the notum is highly abnormal.

External eye morphology is normal in adult survivors expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4elav.PU. However, many of the ommatidia contain only one or two rhabdomeres and large gaps are evident in the retinal tissue.

Adult survivors expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4elav.PU all die within two weeks of eclosion.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
NOT Enhanced by
Suppressed by
NOT suppressed by
Statement
Reference

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has visible phenotype, non-suppressible by l(3)j11B2j11B2/l(3)j11B2[+]

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has visible phenotype, non-suppressible by l(3)j6A6[+]/l(3)j6A6j6A6

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has visible phenotype, non-suppressible by l(3)L0499L0499/l(3)L0499[+]

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has visible phenotype, non-suppressible by l(3)L6332[+]/l(3)L6332L6332

Other
Phenotype Manifest In
Enhanced by
NOT Enhanced by
Statement
Reference
Suppressed by
NOT suppressed by
Statement
Reference

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by CycE[+]/CycEk05007

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by DlicG0190/Dlic[+]

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by eRF100103/eRF1[+]

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by frcL6750/frc[+]

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by Fs(2)KetEY06666/Fs(2)Ket[+]

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by His2Av[+]/His2Av05146

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by Klp61F[+]/Klp61F07012

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by ksrj5E2/ksr[+]

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by Mi-2L1243/Mi-2[+]

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by Nrg[+]/NrgG0099

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by RpS21[+]/RpS21k16804a

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by par-1k06323/par-1[+]

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by RpLP001544/RpLP0[+]

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by sggG0335/sgg[+]

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by smid[+]/smidj6B8

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by Tango5[+]/Tango5G0145b

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by Tis11[+]/Tis11EY09433

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by Vha14-1[+]/Vha14-1EY12998

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by l(3)j11B2j11B2/l(3)j11B2[+]

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by l(3)j6A6[+]/l(3)j6A6j6A6

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by l(3)L0499L0499/l(3)L0499[+]

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by l(3)L6332[+]/l(3)L6332L6332

Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS has eye phenotype, non-suppressible by milt[+]/miltEY14443

Other
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Co-expression of RpidsRNA.Sym.Scer\UAS suppresses the rough eye and loss of eye pigmentation phenotypes seen in adults expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PF. At the ultrastructural level, the structural integrity of the retina is improved, although vacuoles are still present.

Co-expression of ZwGD1203 does not exacerbate the eye defects caused by expression of Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PF.

The addition of ZwGD1203 abolishes the ability of RpidsRNA.Sym.Scer\UAS to suppress the eye defects caused by expression of Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PF, so that the resulting flies have a rough eye which shows loss of pigmentation.

Co-expression of two copies of ZwScer\UAS.cLa can partially rescue the rough eye phenotype caused by expression of Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PF.

Co-expression of RpidsRNA.Sym.Scer\UAS significantly improves rhabdomere structure and rescues photoreceptor neurons in 4 week old flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4ninaE.PT.

Expression of Atg600096 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

Expression of HnRNP-KKG02524 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

Expression of canak07716 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

Expression of crpEY07016 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

Expression of csulEY10871 enhances the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PS.

One copy of CycEk05007 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of DlicG0190 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of ElfEY12435 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of eRF100103 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of frcL6750 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of Fs(2)KetEY06666 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of His2Av05146 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of Hopk14504 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

Expression of Hr39EY04579 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of Klp61F07012 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of ksrj5E2 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of Mi-2L1243 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

Expression of mei-9EY14578 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

Expression of Mekk1EY02276 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of NC2αEY18723 moderately suppresses the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PS.

One copy of NrgG0099 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of RpS21k16804a does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of par-1k06323 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

Expression of Past1EY01852 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of RpLP001544 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

Expression of SdhBEY12081 suppresses the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PS.

One copy of sggG0335 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

Expression of smEY07191 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of smidj6B8 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of Tango5G0145b does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of Tis11EY09433 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

Expression of unc-45EY03034 suppresses the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PS.

One copy of Vha14-1EY12998 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of l(3)j11B2j11B2 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of l(3)j6A6j6A6 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of l(3)L0499L0499 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of l(3)L6332L6332 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

One copy of miltEY14443 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Zzzz\CAGQ108.Scer\UAS
Zzzz\CAGQ108.UAS
Name Synonyms
Secondary FlyBase IDs
    References (8)