FlyBase Allele Report: Zzzz\CAG[Q108.UAS]

General Information

Symbol

Zzzz\CAG^Q108.UAS

Species

a. artificial

Name

FlyBase ID

FBal0137334

Feature type

allele

Associated gene

Zzzz\CAG

Associated Insertion(s)

Carried in Construct

P{UAS-Q108}

Also Known As

UAS-Q108, UAS-108Q

Transgenic product class

trinucleotide_repeat_expansion

(Marsh et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

trinucleotide_repeat_expansion

(Marsh et al., 2000)

Mutagen

in vitro construct

(Kazantsev et al., 2002, Marsh et al., 2000)

Progenitor genotype

Carried in construct

P{UAS-Q108}

Cytology

Description

UAS regulatory sequences drive expression of a 108 amino acid polyglutamine repeat (the repeat is flanked by the amino acid sequence MRSRKL at the N-terminal end and by KLRS at the C-terminal end).

(Marsh et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Zzzz\CAG

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neurodegenerative disease

CEA

(Catterson et al., 2023, Gunawardena et al., 2003, Marsh et al., 2000)

model of Huntington's disease

CEC

(Kazantsev et al., 2002)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of Huntington's disease

is ameliorated by Zzzz\CAG^{Su3.UAS.Tag:MYC}

(Kazantsev et al., 2002)

is ameliorated by Hsap\HTT^{Su3.Scer\UAS.T:Zzzz\CAG,T:Hsap\MYC}

(Kazantsev et al., 2002)

model of neurodegenerative disease

is exacerbated by LanB1^EP-600

(Catterson et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color, with Scer\GAL4^GMR.PF

(Wang et al., 2012, Marsh et al., 2000)

abnormal locomotor behavior | larval stage, with Scer\GAL4^179Y

(Gunawardena et al., 2003)

abnormal locomotor behavior | larval stage, with Scer\GAL4^Appl.G1a

(Gunawardena et al., 2003)

lethal, with Scer\GAL4^dpp.blk1

(Marsh et al., 2000)

lethal, with Scer\GAL4^elav.PU

(Marsh et al., 2000)

lethal, with Scer\GAL4^hs.2sev

(Marsh et al., 2000)

lethal - all die before end of larval stage, with Scer\GAL4^elav.PLu

(Kazantsev et al., 2002)

partially lethal - majority die, with Scer\GAL4^GMR.PF

(Marsh et al., 2000)

short lived, with Scer\GAL4^elav.PU

(Marsh et al., 2000)

short lived | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Catterson et al., 2023)

some die during larval stage, with Scer\GAL4^elav.PLu

(Kazantsev et al., 2002)

visible, with Scer\GAL4^GMR.PF

(Wang et al., 2012, Marsh et al., 2000)

visible | conditional, with Scer\GAL4^ninaE.PT

(Wang et al., 2012)

Phenotype Manifest In

adult head, with Scer\GAL4^dpp.blk1

(Marsh et al., 2000)

eye, with Scer\GAL4^GMR.PF

(Wang et al., 2012, Marsh et al., 2000)

eye photoreceptor cell | conditional, with Scer\GAL4^ninaE.PT

(Wang et al., 2012)

mesonotum, with Scer\GAL4^dpp.blk1

(Marsh et al., 2000)

metathoracic leg, with Scer\GAL4^dpp.blk1

(Marsh et al., 2000)

retina, with Scer\GAL4^elav.PU

(Marsh et al., 2000)

retina, with Scer\GAL4^GMR.PF

(Wang et al., 2012)

rhabdomere, with Scer\GAL4^elav.PU

(Marsh et al., 2000)

rhabdomere | conditional, with Scer\GAL4^ninaE.PT

(Wang et al., 2012)

Detailed Description

Statement

Reference

Expression of Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PF results in rough eyes which show loss of pigmentation. The internal structure of the retina is disrupted and contains large vacuoles.

1 week old flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^ninaE.PT show no degeneration of photoreceptors. However, by 4 weeks of age, the flies show degeneration of photoreceptor neurons and the rhabdomeres are fragmented.

(Wang et al., 2012)

Animals expressing Zzzz\CAG^{Q108.Scer\UAS} driven by Scer\GAL4^179Y or Scer\GAL4^Appl.G1a exhibit aa severe sluggish larval movement phenotype.

(Gunawardena et al., 2003)

Adult survivors expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PF have a rough eye with no pigment.

Pharate adults expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^dpp.blk1 are missing entire third legs, have defects in head capsule evagination and development of the notum is highly abnormal.

External eye morphology is normal in adult survivors expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^elav.PU. However, many of the ommatidia contain only one or two rhabdomeres and large gaps are evident in the retinal tissue.

Adult survivors expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^elav.PU all die within two weeks of eclosion.

(Marsh et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^{elav.Switch.PO}, Zzzz\CAG^Q108.UAS has short lived | RU486 conditional phenotype, enhanceable by LanB1^EP-600, Scer\GAL4^{elav.Switch.PO}

(Catterson et al., 2023)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, enhanceable by csul^EY10871/Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, Zzzz\CAG^Q108.UAS has abnormal eye color phenotype, non-enhanceable by G6pd^GD1203/Scer\GAL4^GMR.PF

(Wang et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CAG^Q108.UAS has visible phenotype, non-enhanceable by G6pd^GD1203/Scer\GAL4^GMR.PF

(Wang et al., 2012)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, Zzzz\CAG^Q108.UAS has visible phenotype, suppressible by Rpi^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Wang et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CAG^Q108.UAS has abnormal eye color phenotype, suppressible by Rpi^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Wang et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CAG^Q108.UAS has visible phenotype, suppressible | partially by G6pd^UAS.cLa/Scer\GAL4^GMR.PF

(Wang et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, suppressible | partially by NC2α^EY18723/NC2alpha[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, suppressible by SdhB^EY12081/Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, suppressible by unc-45^EY03034/Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^elav.PLu, Zzzz\CAG^Q108.UAS has lethal | larval stage phenotype, suppressible | partially by Zzzz\CAG^{Su3.UAS.Tag:MYC}/Scer\GAL4^elav.PLu

(Kazantsev et al., 2002)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by Atg6⁰⁰⁰⁹⁶, Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by HnRNP-K^KG02524, Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by cana^k07716/Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by crp^EY07016/Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by CycE[+]/CycE^k05007

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by Dlic^G0190/Dlic[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by Elf[+]/eRF3^EY12435

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by eRF1⁰⁰¹⁰³/eRF1[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by frc^L6750/frc[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by Fs(2)Ket^EY06666/Fs(2)Ket[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by His2Av[+]/His2Av⁰⁵¹⁴⁶

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by Hop[+]/Stip1^k14504

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by Hr39^EY04579, Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by Klp61F[+]/Klp61F⁰⁷⁰¹²

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by ksr^j5E2/ksr[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by Mi-2^L1243/Mi-2[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by mei-9^EY14578/Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by Mekk1^EY02276, Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by Nrg[+]/Nrg^G0099

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by RpS21[+]/RpS21^k16804a

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by par-1^k06323/par-1[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by Past1^EY01852, Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by RpLP0⁰¹⁵⁴⁴/RpLP0[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by sgg^G0335/sgg[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by sm^EY07191/Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by smid[+]/smid^j6B8

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by Tango5[+]/Tango5^G0145b

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by Tis11[+]/Tis11^EY09433

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by Vha14-1[+]/Vha14-1^EY12998

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by CycT^j11B2/l(3)j11B2[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by l(3)j6A6[+]/l(3)j6A6^j6A6

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by l(3)L0499^L0499/l(3)L0499[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by l(3)L6332[+]/l(3)L6332^L6332

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has visible phenotype, non-suppressible by milt[+]/milt^EY14443

(Ambegaokar and Jackson, 2011)

Other

Statement

Reference

G6pd^GD1203, Rpi^RNAi.Sym.UAS, Scer\GAL4^GMR.PF, Zzzz\CAG^Q108.UAS has visible phenotype

(Wang et al., 2012)

G6pd^GD1203, Rpi^RNAi.Sym.UAS, Scer\GAL4^GMR.PF, Zzzz\CAG^Q108.UAS has abnormal eye color phenotype

(Wang et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, enhanceable by csul^EY10871/Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, Zzzz\CAG^Q108.UAS has eye phenotype, non-enhanceable by G6pd^GD1203/Scer\GAL4^GMR.PF

(Wang et al., 2012)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, Zzzz\CAG^Q108.UAS has eye phenotype, suppressible by Rpi^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Wang et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CAG^Q108.UAS has eye phenotype, suppressible | partially by G6pd^UAS.cLa/Scer\GAL4^GMR.PF

(Wang et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CAG^Q108.UAS has retina phenotype, suppressible | partially by Rpi^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Wang et al., 2012)

Scer\GAL4^ninaE.PT, Zzzz\CAG^Q108.UAS has eye photoreceptor cell | conditional phenotype, suppressible by Rpi^RNAi.Sym.UAS, Scer\GAL4^ninaE.PT

(Wang et al., 2012)

Scer\GAL4^ninaE.PT, Zzzz\CAG^Q108.UAS has rhabdomere | conditional phenotype, suppressible by Rpi^RNAi.Sym.UAS, Scer\GAL4^ninaE.PT

(Wang et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, suppressible | partially by NC2α^EY18723/NC2alpha[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, suppressible by SdhB^EY12081/Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, suppressible by unc-45^EY03034/Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by Atg6⁰⁰⁰⁹⁶, Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by HnRNP-K^KG02524, Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by His2Av[+]/His2Av⁰⁵¹⁴⁶

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by Hop[+]/Stip1^k14504

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by Hr39^EY04579, Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by Klp61F[+]/Klp61F⁰⁷⁰¹²

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by ksr^j5E2/ksr[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by Mi-2^L1243/Mi-2[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by mei-9^EY14578/Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by Mekk1^EY02276, Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by Nrg[+]/Nrg^G0099

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by RpS21[+]/RpS21^k16804a

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by cana^k07716/Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by par-1^k06323/par-1[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by Past1^EY01852, Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by RpLP0⁰¹⁵⁴⁴/RpLP0[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by sgg^G0335/sgg[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by sm^EY07191/Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by smid[+]/smid^j6B8

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by Tango5[+]/Tango5^G0145b

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by Tis11[+]/Tis11^EY09433

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by Vha14-1[+]/Vha14-1^EY12998

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by CycT^j11B2/l(3)j11B2[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by crp^EY07016/Scer\GAL4^GMR.PU

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by l(3)j6A6[+]/l(3)j6A6^j6A6

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by l(3)L0499^L0499/l(3)L0499[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by l(3)L6332[+]/l(3)L6332^L6332

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by milt[+]/milt^EY14443

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by CycE[+]/CycE^k05007

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by Dlic^G0190/Dlic[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by Elf[+]/eRF3^EY12435

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by eRF1⁰⁰¹⁰³/eRF1[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by frc^L6750/frc[+]

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS has eye phenotype, non-suppressible by Fs(2)Ket^EY06666/Fs(2)Ket[+]

(Ambegaokar and Jackson, 2011)

Other

Statement

Reference

G6pd^GD1203, Rpi^RNAi.Sym.UAS, Scer\GAL4^GMR.PF, Zzzz\CAG^Q108.UAS has eye phenotype

(Wang et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Rpi^{dsRNA.Sym.Scer\UAS} suppresses the rough eye and loss of eye pigmentation phenotypes seen in adults expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PF. At the ultrastructural level, the structural integrity of the retina is improved, although vacuoles are still present.

Co-expression of Zw^GD1203 does not exacerbate the eye defects caused by expression of Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PF.

The addition of Zw^GD1203 abolishes the ability of Rpi^{dsRNA.Sym.Scer\UAS} to suppress the eye defects caused by expression of Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PF, so that the resulting flies have a rough eye which shows loss of pigmentation.

Co-expression of two copies of Zw^Scer\UAS.cLa can partially rescue the rough eye phenotype caused by expression of Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PF.

Co-expression of Rpi^{dsRNA.Sym.Scer\UAS} significantly improves rhabdomere structure and rescues photoreceptor neurons in 4 week old flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^ninaE.PT.

(Wang et al., 2012)

Expression of Atg6⁰⁰⁰⁹⁶ does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

Expression of HnRNP-K^KG02524 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

Expression of cana^k07716 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

Expression of crp^EY07016 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

Expression of csul^EY10871 enhances the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PS.

One copy of CycE^k05007 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of Dlic^G0190 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of Elf^EY12435 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of eRF1⁰⁰¹⁰³ does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of frc^L6750 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of Fs(2)Ket^EY06666 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of His2Av⁰⁵¹⁴⁶ does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of Hop^k14504 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

Expression of Hr39^EY04579 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of Klp61F⁰⁷⁰¹² does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of ksr^j5E2 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of Mi-2^L1243 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

Expression of mei-9^EY14578 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

Expression of Mekk1^EY02276 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of NC2α^EY18723 moderately suppresses the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PS.

One copy of Nrg^G0099 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of RpS21^k16804a does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of par-1^k06323 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

Expression of Past1^EY01852 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of RpLP0⁰¹⁵⁴⁴ does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

Expression of SdhB^EY12081 suppresses the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PS.

One copy of sgg^G0335 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

Expression of sm^EY07191 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of smid^j6B8 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of Tango5^G0145b does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of Tis11^EY09433 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

Expression of unc-45^EY03034 suppresses the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PS.

One copy of Vha14-1^EY12998 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of l(3)j11B2^j11B2 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of l(3)j6A6^j6A6 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of l(3)L0499^L0499 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of l(3)L6332^L6332 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

One copy of milt^EY14443 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

(Ambegaokar and Jackson, 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

68393

w^*; P{UAS-Q108}16

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Zzzz\CAG^{Q108.Scer\UAS}

Zzzz\CAG^Q108.UAS

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

Open Close