FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\His2Av05146
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General Information
Symbol
Dmel\His2Av05146
Species
D. melanogaster
Name
FlyBase ID
FBal0009530
Feature type
allele
Associated gene
Dmel\His2Av
Associated Insertion(s)
P{PZ}His2Av05146
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
Progenitor genotype
Associated Insertion(s)
P{PZ}His2Av05146
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  tauopathy
      modeled by Hsap\MAPTGMR.Ex.PJ
      (Ambegaokar and Jackson, 2011)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      His2Av[+]/His2Av05146 is an enhancer of visible phenotype of DpUAS.cDa, E2f1UAS.cNa, Scer\GAL4GMR.PU

      (Ji et al., 2012)

      His2Av[+]/His2Av05146 is an enhancer of visible phenotype of Hsap\MAPTGMR.Ex.PJ

      (Ambegaokar and Jackson, 2011)
      Suppressor of
      Statement
      Reference

      His2Av[+]/His2Av05146 is a suppressor of visible phenotype of E2f1RNAi.UAS.cJa, Scer\GAL4ptc-559.1

      (Ji et al., 2012)

      His2Av[+]/His2Av05146 is a suppressor of visible phenotype of E2f1RNAi.UAS.cJa, Scer\GAL4GMR.PU

      (Ji et al., 2012)

      His2Av05146 is a suppressor | partially of visible | dominant phenotype of ash117, trxB11/trx[+]

      (Swaminathan et al., 2005)

      His2Av05146 is a suppressor of visible phenotype of upd1GMR.PB

      (Bach et al., 2003)
      NOT Suppressor of
      Statement
      Reference

      His2Av[+]/His2Av05146 is a non-suppressor of visible phenotype of Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS

      (Ambegaokar and Jackson, 2011)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      His2Av[+]/His2Av05146 is an enhancer of eye phenotype of DpUAS.cDa, E2f1UAS.cNa, Scer\GAL4GMR.PU

      (Ji et al., 2012)

      His2Av[+]/His2Av05146 is an enhancer of eye phenotype of Hsap\MAPTGMR.Ex.PJ

      (Ambegaokar and Jackson, 2011)
      Suppressor of
      Statement
      Reference

      His2Av[+]/His2Av05146 is a suppressor of eye phenotype of E2f1RNAi.UAS.cJa, Scer\GAL4GMR.PU

      (Ji et al., 2012)

      His2Av[+]/His2Av05146 is a suppressor of first posterior wing cell phenotype of E2f1RNAi.UAS.cJa, Scer\GAL4ptc-559.1

      (Ji et al., 2012)

      His2Av05146 is a suppressor | partially of mesothoracic tibial apical bristle | ectopic phenotype of ash117, trxB11/trx[+]

      (Swaminathan et al., 2005)

      His2Av05146 is a suppressor | partially of metathoracic leg phenotype of ash117, trxB11/trx[+]

      (Swaminathan et al., 2005)

      His2Av05146 is a suppressor of eye phenotype of upd1GMR.PB

      (Bach et al., 2003)
      NOT Suppressor of
      Statement
      Reference

      His2Av[+]/His2Av05146 is a non-suppressor of eye phenotype of Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS

      (Ambegaokar and Jackson, 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      One copy of His2Av05146 does not suppress the apoptosis seen in flies overexpressing hid.

      (Ambegaokar and Jackson, 2011)

      His2Av05146/+ enhances the frequency of transformation of the second or third leg to first leg that is seen in Df(3L)Pc/+ flies; 33% of the double heterozygous males have sex combs on all four second and third legs and 40% of the double heterozygous males have sex combs on both the second legs and one of the third legs (compared to 14.5% of Df(3L)Pc/+ males having sex combs on the second and/or third legs). The frequency of the appearance of an apical bristle on the third leg decreases to 37% in ash117 trxB11 His2Av05146 triple heterozygotes compared to ash117 trxB11 double heterozygotes.

      (Swaminathan et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference

      One copy of His2Av05146 enhances the rough eye phenotype seen in flies expressing Hsap\MAPTGMR.Ex.PJ. Necrotic plaques are also seen.

      One copy of His2Av05146 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

      (Ambegaokar and Jackson, 2011)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      A. Spradling.

      Separable from: Ssedft.

      (Cipressa et al., 2016)

      The "l(3)05146" chromosome carries two separate mutations: His2Av05146 and the second site mutation Ssedft.

      (Cipressa et al., 2016)
      Comments
      Comments

      Complements: l(3)0196901969. Complements: l(3)0267002670. Complements: l(3)0388403884. Complements: l(3)neo591. Complements: l(3)rK344rK344.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      His2Av05146
      (Ambegaokar and Jackson, 2011, Schuh et al., 2007)
      His2AvD05146
      (Ji et al., 2012)
      l(3)05146
      (Spradling et al., 1999)
      l(3)0514605146
      (Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project, 1993.6.1)
      Name Synonyms
      Secondary FlyBase IDs
        References (12)