FlyBase Allele Report: Dmel\Mi-2[L1243]

General Information

Symbol

Dmel\Mi-2^L1243

Species

D. melanogaster

Name

FlyBase ID

FBal0086993

Feature type

allele

Associated gene

Dmel\Mi-2

Associated Insertion(s)

P{lacW}Mi-2^L1243

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}Mi-2^L1243

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:19,897,070..19,897,070 [+]

(Lenz et al., 2021, Cooper et al., 2010, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Mi-2^L1243/Mi-2[+] is a suppressor of visible phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

NOT Suppressor of

Statement

Reference

Mi-2^L1243/Mi-2[+] is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

Phenotype Manifest In

Suppressor of

Statement

Reference

Mi-2^L1243/Mi-2[+] is a suppressor of eye phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

NOT Suppressor of

Statement

Reference

Mi-2^L1243/Mi-2[+] is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of Mi-2^L1243 does not suppress the apoptosis seen in flies overexpressing hid.

(Ambegaokar and Jackson, 2011)

Xenogenetic Interactions

Statement

Reference

One copy of Mi-2^L1243 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of Mi-2^L1243 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

(Ambegaokar and Jackson, 2011)

Complementation and Rescue Data

Fails to complement

Mi-2^unspecified

(Cooper et al., 2010)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

10196

y¹ w¹¹¹⁸; P{lacW}Mi-2^L1243/TM3, Ser¹

Notes on Origin

Discoverer

Comments

Complements: Mi-2^j3D4.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Mi-2^L1243

(Lenz et al., 2021, Ambegaokar and Jackson, 2011)

l(3)L1243

(Spradling et al., 1999)

l(3)L1243^L1243

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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