FlyBase Allele Report: Dmel\G6pd[GD1203]

General Information

Symbol

Dmel\G6pd^GD1203

Species

D. melanogaster

Name

FlyBase ID

FBal0209029

Feature type

allele

Associated gene

Dmel\G6pd

Associated Insertion(s)

Carried in Construct

P{GD1203}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1203}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1203

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates adult-onset myofibrillar myopathy 2A

modeled by Hsap\CRYAB^R120G.UAS

(Xie et al., 2013)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body color, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

mesonotum, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Detailed Description

Statement

Reference

Adults expressing Zw^GD1203 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in a colour difference between the central Scer\GAL4^pnr-MD237 expression domain of the notum and the surrounding lateral region in 0% or 100% of the Scer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1203

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

G6pd^GD1203/Scer\GAL4^GMR.PF is a non-enhancer of abnormal eye color phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^Q108.UAS

(Wang et al., 2012)

G6pd^GD1203/Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^Q108.UAS

(Wang et al., 2012)

Suppressor of

Statement

Reference

G6pd^GD1203, Scer\GAL4^GMR.PF is a suppressor | partially of visible | adult stage phenotype of Hsap\CRYAB^R120G.UAS, Scer\GAL4^GMR.PF

(Xie et al., 2013)

Other

Statement

Reference

G6pd^GD1203, Rpi^RNAi.Sym.UAS, Scer\GAL4^GMR.PF, Zzzz\CAG^Q108.UAS has visible phenotype

(Wang et al., 2012)

G6pd^GD1203, Rpi^RNAi.Sym.UAS, Scer\GAL4^GMR.PF, Zzzz\CAG^Q108.UAS has abnormal eye color phenotype

(Wang et al., 2012)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

G6pd^GD1203/Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^Q108.UAS

(Wang et al., 2012)

Suppressor of

Statement

Reference

G6pd^GD1203, Scer\GAL4^GMR.PF is a suppressor | partially of eye phenotype of Hsap\CRYAB^R120G.UAS, Scer\GAL4^GMR.PF

(Xie et al., 2013)

Other

Statement

Reference

G6pd^GD1203, Rpi^RNAi.Sym.UAS, Scer\GAL4^GMR.PF, Zzzz\CAG^Q108.UAS has eye phenotype

(Wang et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Zw^GD1203 does not exacerbate the eye defects caused by expression of Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PF.

The addition of Zw^GD1203 abolishes the ability of Rpi^{dsRNA.Sym.Scer\UAS} to suppress the eye defects caused by expression of Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PF, so that the resulting flies have a rough eye which shows loss of pigmentation.

(Wang et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v3337

w¹¹¹⁸; P{GD1203}v3337

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1203

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

G6pd^GD1203

Zw^GD1203

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

Open Close