FB2026_02 , released June 18, 2026
Allele: Dmel\SdhBEY12081
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General Information
Symbol
Dmel\SdhBEY12081
Species
D. melanogaster
Name
FlyBase ID
FBal0159760
Feature type
allele
Associated gene
Dmel\SdhB
Associated Insertion(s)
P{EPgy2}SdhBEY12081
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}SdhBEY12081
Cytology
Description

P{EPgy2}SdhBEY12081 is inserted within the 5'UTR of SdhB.

(Walker et al., 2006)
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  mitochondrial complex II deficiency
      CEA
      (Fan et al., 2019, Walker et al., 2006)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  tauopathy
      modeled by Hsap\MAPTGMR.Ex.PJ
      (Ambegaokar and Jackson, 2011)
      ameliorates  Parkinson's disease 2
      modeled by park25
      (O'Hanlon et al., 2022)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants hold their wings erect (indicative of mitochondrial dysfunction and muscle degeneration) when maintained either under normal conditions or hyperoxia. Mutants also show a marked reduction in lifespan relative to controls in response to hyperoxia.

      (Na et al., 2014)

      Under hyperoxia, the mean survival time of SdhBEY12081 flies is reduced to 10% of that of normal flies.

      Young flight muscles in SdhBEY12081 mutants do not display major defects in the flight muscle mitochondria, but after 15 hours of hyperoxia exhibit severe mitochondrial pathology. The majority of mitochondria are severely damaged and their cristae in disarray, whereas the myofibrils appear unaffected.

      Under normal conditions SdhBEY12081 flies display a 66% decrease in mean survival time and a 17% decrease in maximum survival time.

      At 2 days of age, SdhBEY12081 mutant flies appear normal in climbing assays, but this rapidly declines with age. At 8 days, mutant flies display a 54% decrease, and at 12 days they exhibit a 77% decrease in climbing score, whereas normal flies show no decline in that time.

      Complex I-specific (pyruvate/malate-dependent/rotenone-sensitive) respiration rate in normal in SdhBEY12081 mutants, as is the complex IV-specific (ascorbate/TMPD-dependent/KCN-sensitive) respiration rate. However, there is a 56% decrease in the complex II-specific (succinate-dependent/antimycin-A-sensitive) respiration rate. Complex II-mediated electron transer is reduced by 40% in SdhBEY12081 mutants. Mitochondria from SdhBEY12081 mutants exhibit a 32% increase in hydrogen peroxide production, as compared to wild-type controls.

      (Walker et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of SdhBEY12081 under the control of Scer\GAL4GMR.PS suppresses the rough eye phenotype seen in flies expressing Hsap\MAPTGMR.Ex.PJ.

      Expression of SdhBEY12081 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPTScer\UAS.S11A under the control of Scer\GAL4GMR.PS.

      Expression of SdhBEY12081 suppresses the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PS.

      Expression of SdhBEY12081 does not suppress the eye phenotype seen in flies expressing Hsap\APP2xAPP.SP.Scer\UAS under the control of Scer\GAL4GMR.PS.

      Expression of SdhBEY12081 does not suppress the eye phenotype seen in flies expressing Hsap\TARDBPQ331K.Scer\UAS.cLa under the control of Scer\GAL4GMR.PS.

      (Ambegaokar and Jackson, 2011)
      Complementation and Rescue Data
      Rescued by

      SdhBEY12081 is rescued by SdhB+tWa

      (Walker et al., 2006)
      Comments

      SdhB+tWa restores normal hyperoxia-resistance to SdhBEY12081 flies.

      (Walker et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      SdhB12081
      (Na et al., 2014)
      SdhBEY12081
      (O'Hanlon et al., 2022, Ambegaokar and Jackson, 2011)
      sdhBey12081
      (Fan et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)