FlyBase Allele Report: Dmel\Sirup[1]

General Information

Symbol

Dmel\Sirup¹

Species

D. melanogaster

Name

FlyBase ID

FBal0298014

Feature type

allele

Associated gene

Dmel\Sirup

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

TALEN

Nature of the Allele

Allele class

Mutagen

TALEN

(Van Vranken et al., 2014)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

bang sensitive (with Sirup²)

(Van Vranken et al., 2014)

bang sensitive (with Sirup³)

(Van Vranken et al., 2014)

short lived (with Sirup²)

(Van Vranken et al., 2014)

viable (with Sirup²)

(Van Vranken et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Sirup¹/Sirup² flies have a median lifespan of only 12 days compared to that of 69 days for controls.

Sirup¹/Sirup² flies show neurodegeneration in the retina: the photoreceptors are highly vesicularised and mitochondria have abnormal morphology.

(Van Vranken et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Sirup¹/Sirup² has bang sensitive phenotype, suppressible | partially by Scer\GAL4^da.PU/Hsap\SDHAF4^UAS.cVa

(Van Vranken et al., 2014)

Other

Statement

Reference

SdhA[+]/SdhA^HP21216, Sirup¹/Sirup² has partially lethal - majority die phenotype

(Van Vranken et al., 2014)

SdhB^EY12081, Sirup¹/Sirup² has partially lethal - majority die phenotype

(Van Vranken et al., 2014)

CoVa[+]/COX5A^tend, Sirup¹/Sirup² has viable phenotype

(Van Vranken et al., 2014)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\SDHAF4^Scer\UAS.cVa under the control of Scer\GAL4^da.PU partially rescues the bang sensitivity of Sirup¹/Sirup² flies.

(Van Vranken et al., 2014)

Complementation and Rescue Data

Rescued by

Sirup¹/Sirup² is rescued by Scer\GAL4^elav.PU/Sirup^UAS.cVa

(Van Vranken et al., 2014)

Sirup¹/Sirup² is rescued by Scer\GAL4^da.PU/Sirup^UAS.cVa

(Van Vranken et al., 2014)

Partially rescued by

Sirup¹/Sirup² is partially rescued by Sirup^UAS.cVa

(Van Vranken et al., 2014)

Comments

Expression of Sirup^Scer\UAS.cVa under the control of either Scer\GAL4^elav.PU or Scer\GAL4^da.PU rescues the bang sensitivity of Sirup¹/Sirup² flies (partial rescue of the phenotype is also seen in the absence of a driver).

(Van Vranken et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

76570

w¹¹¹⁸; Sirup¹/CyO, P{GAL4-twi.G}2.2, P{UAS-2xEGFP}AH2.2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Sirup¹

dSdhaf4¹

(Van Vranken et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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