FlyBase Gene Report: Dmel\SdhB

General Information

Symbol

Dmel\SdhB

Species

D. melanogaster

Name

Succinate dehydrogenase, subunit B (iron-sulfur)

Annotation Symbol

CG3283

Feature Type

protein_coding_gene

FlyBase ID

FBgn0014028

Gene Model Status

Current

Stock Availability

8 publicly available

Enzyme Name (EC)

succinate dehydrogenase (1.3.5.1)

Gene Summary

Succinate dehydrogenase, subunit B (iron-sulfur) (SdhB) encodes the iron-sulfur cluster-containing subunit of the mitochondrial succinate dehydrogenase complex, also known as respiratory chain complex II. This complex catalyzes the sixth step of the of the tricarboxylic acid (TCA) cycle by oxidizing succinate to fumarate and also transfers electrons to quinones as part of the electron transport chain. The redox-active cofactors in this subunit are part of the electron transfer machinery in the complex. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Succinate dehydrogenase B, succinate dehydrogenase, SDH

Key Links

Genomic Location

Cytogenetic map

42D3-42D4

Sequence location

2R:6,807,626..6,809,172 [+]

Recombination map

2-55

RefSeq locus

NT_033778 REGION:6807626..6809172

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (15 terms)

Molecular Function (8 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (8 terms)

CV Term

Evidence

References

enables 2 iron, 2 sulfur cluster binding

inferred from sequence or structural similarity with UniProtKB:Q007T0

(Gene Ontology Curators, 2002-)

inferred from electronic annotation with InterPro:IPR006058

(InterPro Project Members, 2004-)

enables 3 iron, 4 sulfur cluster binding

inferred from sequence or structural similarity with UniProtKB:Q007T0

(Gene Ontology Curators, 2002-)

enables 4 iron, 4 sulfur cluster binding

inferred from sequence or structural similarity with UniProtKB:Q007T0

(Gene Ontology Curators, 2002-)

enables electron transfer activity

inferred from electronic annotation with InterPro:IPR025192

(InterPro Project Members, 2004-)

enables iron-sulfur cluster binding

inferred from electronic annotation with InterPro:IPR001041, InterPro:IPR009051, InterPro:IPR025192, InterPro:IPR036010

(InterPro Project Members, 2004-)

enables oxidoreductase activity

inferred from electronic annotation with InterPro:IPR004489

(InterPro Project Members, 2004-)

contributes_to succinate dehydrogenase (quinone) activity

inferred from sequence or structural similarity with UniProtKB:Q9CQA3

(Gene Ontology Curators, 2002-)

enables ubiquinone binding

inferred from sequence or structural similarity with UniProtKB:Q007T0

(Gene Ontology Curators, 2002-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in mitochondrial electron transport, succinate to ubiquinone

inferred from direct assay

(Walker et al., 2006)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in aerobic respiration

inferred from biological aspect of ancestor with PANTHER:PTN000229864

(GO Reference Genome Project, 2011-)

involved_in mitochondrial electron transport, succinate to ubiquinone

non-traceable author statement

(Tripoli et al., 2005)

involved_in respiratory electron transport chain

inferred from biological aspect of ancestor with PANTHER:PTN000229864

(GO Reference Genome Project, 2011-)

involved_in tricarboxylic acid cycle

inferred from electronic annotation with InterPro:IPR004489

(InterPro Project Members, 2004-)

traceable author statement

(Van Vranken et al., 2014)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in mitochondrial inner membrane

non-traceable author statement

(Tripoli et al., 2005)

located_in mitochondrial inner membrane

inferred from sequence or structural similarity with UniProtKB:Q007T0

(Gene Ontology Curators, 2002-)

is_active_in mitochondrial membrane

inferred from biological aspect of ancestor with PANTHER:PTN000229867

(GO Reference Genome Project, 2011-)

part_of respiratory chain complex II (succinate dehydrogenase)

inferred from sequence or structural similarity with UniProtKB:Q007T0

(Gene Ontology Curators, 2002-)

non-traceable author statement

(Porcelli et al., 2007, Tripoli et al., 2005)

Gene Group (FlyBase)

MITOCHONDRIAL COMPLEX II (SUCCINATE DEHYDROGENASE) SUBUNITS

MITOCHONDRIAL COMPLEX II (SUCCINATE DEHYDROGENASE)

Pathway (FlyBase)

TRICARBOXYLIC ACID (TCA) CYCLE

OXIDATIVE PHOSPHORYLATION

Protein Family (UniProt)

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (P21914)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

succinate dehydrogenase (quinone) activity

a quinone + succinate = fumarate + a quinol (1.3.5.1)

RHEA 40523:

Summaries

Gene Snapshot

Gene Group (FlyBase)

MITOCHONDRIAL COMPLEX II (SUCCINATE DEHYDROGENASE) SUBUNITS -: The succinate dehydrogenase complex is unique in that it functions in both the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC), wherein it is referred to as Complex II. It is a heterotetrameric protein complex that is anchored to the inner mitochondrial membrane by two integral membrane proteins, Sdh3 (SDHC) and Sdh4 (SDHD). This Sdh3/Sdh4 dimer binds the peripheral membrane protein Sdh2 (SDHB), which tethers the Sdh1 (SDHA) subunit to the complex. Sdh1 harbors a covalently bound FAD cofactor that is required for the oxidation of succinate to fumarate in the TCA cycle. The two electrons that result from succinate oxidation are channeled through the three iron-sulfur clusters in Sdh2 to ubiquinone, which interacts with the complex via the Sdh3/Sdh4 membrane anchor, and thereby reduce it to ubiquinol as part of the ETC. (Adapted from PMID:24954416 and PMID:37490987.)
MITOCHONDRIAL COMPLEX II (SUCCINATE DEHYDROGENASE) -: Mitochondrial complex II/Succinate Dehydrogenase is a heterotetrameric protein complex anchored to the inner mitochondrial membrane via two integral membrane subunits. It functions both in the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC) by catalysing the oxidation of succinate to fumarate and then, via electron transfer, reducing ubiquinone to ubiquinol. (Adapted from PMID:24954416.)

Pathway (FlyBase)

TRICARBOXYLIC ACID (TCA) CYCLE -: The tricarboxylic acid (TCA) cycle is a central metabolic process that occurs in mitochondria. It consists of a cyclic series of chemical reactions that harness high-energy electrons from nutrients to produce energy (ATP). Each turn of the TCA cycle oxidizes one acetyl-CoA to two CO2 molecules and yields one GTP or ATP and 6 electrons in the form of four reducing equivalents (three NADH and one FADH2). Then, these electron carriers transfer their electrons onto the electron transport chain (ETC) complexes to generate ATP in a process known as oxidative phosphorylation (OXPHOS). The TCA cycle intermediates can also be used as precursors for the biosynthesis of amino acids, fatty acids and porphyrins and for gluconeogenesis. (Adapted from PMID:36581208).
OXIDATIVE PHOSPHORYLATION -: Oxidative phosphorylation (OXPHOS) is the coordinated transfer of electrons and protons leading to the production of ATP. The OXPHOS system is composed of five mitochondrial inner membrane complexes, Complexes I-IV comprise the electron respiratory chain and Complex V the ATP synthase. Complexes I and II oxidize the electron donors NADH and FADH2, respectively, derived from the tricarboxylic acid (TCA) cycle, and the electrons are transferred to the electron carrier ubiquinone which shuttles them to Complex III. Cytochrome c transfers electrons between Complex III and the terminal complex in the respiratory chain, Complex IV. Complex IV catalyzes electron transfer from reduced cytochrome c to oxygen. Complex I, II and IV couple electron transfer to proton transport across the inner mitochondrial membrane into the inner membrane space. This generates a proton electrochemical gradient which is used to drive the synthesis of ATP from ADP and inorganic phosphate by ATP synthase (Complex V). (Adapted from PMID:23356252 and PMID:11331900.)

Protein Function (UniProtKB)

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

(UniProt, P21914)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\SdhB for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P21914)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

SdhB-RA

FBtr0086156

NM_057753

1219

297

Additional Transcript Data and Comments

Reported size (kB)

1.3 (northern blot)

(Au and Scheffler, 1994)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

SdhB-PA

FBpp0085489

33.7

297

8.79

P21914

NP_477101

AAF57396

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

297 (aa)

(Au and Scheffler, 1994)

Comments

External Data

Subunit Structure (UniProtKB)

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.

(UniProt, P21914)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P21914

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SdhB using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.89

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

dorsal pharyngeal muscle cell

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

larval muscle system

(Fisher et al., 2012)

larval somatic muscle cell

(Fisher et al., 2012)

larval visceral muscle cell

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage & adult stage

(Au and Scheffler, 1994)

adult stage

adult thorax

(Au and Scheffler, 1994)

adult head

(Au and Scheffler, 1994)

Additional Descriptive Data

SdhB transcripts are detected in RNA from larvae and adults on northern blots. In adults they are most abundant in the thorax and are barely detectable in the abdomen.

(Au and Scheffler, 1994)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\SdhB in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\SdhB

View exonic expression by tissue for Dmel\SdhB

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0014028

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35590/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0014028

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0014028

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0014028

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3283

Flygut - An atlas of the Drosophila adult midgut

FBgn0014028

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\SdhB

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of SdhB

Transgenic constructs containing regulatory region of SdhB

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)Exel6050

(Ryder, 2004.4.26)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

SdhB^EY12081

Sterility

Allele

fertile

SdhB^EY12081

Other Phenotypes

Allele

abnormal locomotor behavior | adult stage

SdhB^EY12081

abnormal oxidative stress response

SdhB^EY12081

abnormal stress response

SdhB^EY12081

short lived | chemical conditional

SdhB^EY12081

Phenotype manifest in

Allele

flight muscle cell

SdhB^EY12081

mitochondrial crista

SdhB^EY12081

mitochondrion

SdhB^EY12081

wing | conditional

SdhB^EY12081

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

Hsap\SDHB

14 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

Rnor\Sdhb

14 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\Sdhb

13 of 14

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\sdhb

11 of 13

Yes

Danio rerio (Zebrafish) (1)

Drer\sdhb

14 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\sdhb-1

13 of 14

Yes

Cele\F42A8.1

2 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP007309

12 of 12

Yes

Arabidopsis thaliana (thale-cress) (3)

Atha\SDH2-1

13 of 13

Yes

Atha\SDH2-2

13 of 13

Yes

Atha\SDH2-3

8 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\SDH2

13 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\sdh2

12 of 12

Yes

Escherichia coli (enterobacterium) (3)

Ecol\sdhB

9 of 11

Yes

Ecol\frdB

4 of 11

Yes

Ecol\glcF

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:SdhB. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

SdhBL

10 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

mitochondrial complex II deficiency, nuclear type 4

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

SdhB^EY12081

model of mitochondrial complex II deficiency

CEA

(Fan et al., 2019, Walker et al., 2006)

SdhB^ex66

model of mitochondrial complex II deficiency

CEA

(Walker et al., 2006)

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

SDHB; succinate dehydrogenase complex iron sulfur subunit B

model of Carney-Stratakis syndrome

IEA

(FlyBase, 2019-)

model of gastrointestinal stromal tumor

IEA

(FlyBase, 2019-)

model of pheochromocytoma/paraganglioma syndrome 4

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

SdhB^EY12081

ameliorates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

ameliorates Parkinson's disease 2

modeled by park²⁵

(O'Hanlon et al., 2022)

SdhB^c00364

ameliorates Parkinson's disease 2

modeled by park²⁵

(O'Hanlon et al., 2022)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SDHB; succinate dehydrogenase complex iron sulfur subunit B

14 of 14

185470

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

SdhB - Irp-1A

anti tag coimmunoprecipitation, quantitative reverse transcription pcr

(Huynh et al., 2019)

SdhB - smg

anti bait coimmunoprecipitation, primer specific pcr

(Chartier et al., 2015)

protein-protein

Physical Interaction

Assay

References

SdhB - SdhA

blue native page, peptide massfingerprinting

(Rahman et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.

(UniProt, P21914 )

Linkouts

BioGRID - A database of protein and genetic interactions.

61486

DroID - A comprehensive database of gene and protein interactions.

FBgn0014028

MIST (protein-protein) - An integrated Molecular Interaction Database

35590

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

TRICARBOXYLIC ACID (TCA) CYCLE
OXIDATIVE PHOSPHORYLATION

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Citric acid cycle (TCA cycle)

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Citric acid cycle (TCA cycle)

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-55

Cytogenetic map

42D3-42D4

Sequence location

2R:6,807,626..6,809,172 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

42D3-42D4

Limits computationally determined from genome sequence between P{lacW}geminin^k14019&P{PZ}Adf1⁰¹³⁴⁹ and P{lacW}ubl^k03203&P{PZ}CG3287⁰⁹⁹⁶⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

42D1-42D5

(determined by in situ hybridisation)

(Au and Scheffler, 1994)

Experimentally Determined Recombination Data

Location

2-55

(FlyBase, 2016)

2-56.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

10039

w¹¹¹⁸; PBac{PB}SdhB^c00364/CyO

20343

y¹ w^67c23; P{EPgy2}SdhB^EY12081/CyO

79668

y¹ sc^* v¹ sev²¹; P{TOE.GS01238}attP40

80737

y¹ sc^* v¹ sev²¹; P{TKO.GS01782}attP40

3283R-1

3283R-2

v330617

v330618

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (149)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD23740

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0014028

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0014028

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

SdhB is critical in preventing electron leakage from complex II, so that mutant animals suffer from increased oxidative stress and, as a result, are highly sensitive to oxygen and die rapidly.

(Walker et al., 2006)

Irp binds to an iron response element (IRE) in the 5' untranslated region of the mRNA encoding the iron-sulphur (Ip) protein subunit of succinate dehydrogenase (SdhB). This interaction is developmentally regulated during embryogenesis.

(Gray et al., 1996)

Functionality of SdhB is demonstrated by showing translational regulation in vivo in response to iron treatment.

(Melefors, 1996)

SdhB mRNA has a iron-responsive element (IRE) in the 5' untranslated region at 71 nucleotides. The SdhB IRE mediates translational inhibition in both insect and vertebrate cells.

(Kohler et al., 1995)

Isolated from a genomic library, using a human Ip (iron-sulphur protein subunit of succinate dehydrogenase) cDNA as a probe, under low stringency conditions.

(Au and Scheffler, 1994)

SdhB has been cloned and characterised.

(Au and Scheffler, 1994)

The partial cDNA reported previously for SdhB (FBrf0050820) does not correspond to SdhB and probably arose from a mix-up or contamination.

(Gould et al., 1993)

A partial cDNA believed to correspond to SdhB has been cloned by PCR and sequenced. It has subsequently been shown (Gould et al., 1993, Proc. natn. Acad. Sci. USA. 90, 2556) that the sequence of this clone does not correspond to SdhB and probably arose from a mix-up or contamination.

(Gould et al., 1989)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (26)

Reported As

Symbol Synonym

CG3283

(Curcio et al., 2024, Ibaraki et al., 2021, Meadows, 2018.10.31, Garcia et al., 2017, Çiçek et al., 2016, Foriel et al., 2015, Rosa-Ferreira et al., 2015, Jaspers et al., 2012, Cammarato et al., 2011, Tiefenböck et al., 2010, Hughes et al., 2008, Porcelli et al., 2007, Caggese et al., 2006)

CII-SDHB

(Tufi et al., 2014)

DHSB

(Caggese et al., 2006)

(Schwarze et al., 1998)

SDH

(Prasad and Muralidhara, 2014, Walker et al., 2006)

SDH-B

(Tiefenböck et al., 2010)

SDH-IP

(Melefors, 1996)

SDH-Ip

(Gray et al., 1996)

SDHB

(Meyer et al., 2024)

SDHb

(Surdej et al., 2008, Kohler et al., 1995)

Sdhb

(Takács-Vellai et al., 2021, Slaninova et al., 2016)

sdhB

(Ishii et al., 2025, Fan et al., 2019, Zhang et al., 2016, Jasper, 2015, Ishii et al., 2013, Rera et al., 2012, Walker et al., 2006, Au, 1994.3.8)

Name Synonyms

COMPLEX II: iron-sulfur subunit

(Porcelli et al., 2007)

Succinate dehydrogenase

(Feng et al., 2015)

Succinate dehydrogenase B

(Jaspers et al., 2012, Ambegaokar and Jackson, 2011, Cammarato et al., 2011, Lebo et al., 2009)

Succinate dehydrogenase Iron Protein

(Melefors, 1996)

Succinate dehydrogenase Iron-sulfur

(Porcelli et al., 2007)

Succinate dehydrogenase Iron-sulfur protein

(Tripoli et al., 2005)

Succinate dehydrogenase [ubiquinone] iron-sulfur protein

(Caggese et al., 2006)

Succinate dehydrogenase, subunit B (iron-sulfur)

(Porcelli and Marygold, 2014.9.16)

iron-sulfur protein subunit of succinate dehydrogenase

(Gray et al., 1996)

succinate dehydrogenase

(Celotto et al., 2011, Walker et al., 2006)

succinate dehydrogenase B

(Zhan et al., 2007)

succinate dehydrogenase complex subunit B

(Xia et al., 2020)

succinate dehydrogenase subunit b

(Surdej et al., 2008)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 55 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35590

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P21914

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P21914

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P21914

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0014028

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35590/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0014028

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0014028

FlyMine - An integrated database for Drosophila genomics

FBgn0014028

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3283

MARRVEL_MODEL - MARRVEL (model organism gene)

35590

Linkouts

BioGRID - A database of protein and genetic interactions.

61486

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0014028

DroID - A comprehensive database of gene and protein interactions.

FBgn0014028

DRSC - Results frm RNAi screens

FBgn0014028

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0014028

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0014028

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3283

Flygut - An atlas of the Drosophila adult midgut

FBgn0014028

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0014028

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC011988

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

35590

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Citric acid cycle (TCA cycle)

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Citric acid cycle (TCA cycle)

References (101)

The following external sites may use different assemblies or annotations than FlyBase.

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