FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term tricarboxylic acid cycle ID (Ontology) GO:0006099 (Gene Ontology)
Definition A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.[ ISBN:0198506732 ]
Also Known As"citric acid cycle" ; "Krebs cycle" ; "oxidative TCA cycle" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
Genes (FBgn)GO_CELLULAR_COMPONENT
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 tricarboxylic acid cycle (all annotations which use CV term, excluding "NOT" statements)
     involved_in | tricarboxylic acid cycle       --
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metabolic process
 |__primary metabolic process__
cellular respiration           |
 |__aerobic respiration________|
                               tricarboxylic acid cycle  50 rec.
                                |__2-oxoglutarate decarboxylation to succinyl-CoA 7 rec.
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Is a primary metabolic process
Part of aerobic respiration
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Synonyms
  • "citric acid cycle" EXACT
    "Krebs cycle" EXACT
    "oxidative TCA cycle" EXACT
    "TCA cycle" EXACT
Secondary IDs
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MetaCyc:P105-PWY
MetaCyc:PWY-5690
MetaCyc:PWY-5913
MetaCyc:PWY-6969
MetaCyc:PWY-7254
MetaCyc:PWY66-398
MetaCyc:REDCITCYC
MetaCyc:TCA
MetaCyc:TCA-1
Reactome:R-HSA-71403 "Citric acid cycle (TCA cycle)"
Wikipedia:Tricarboxylic_acid_cycle