Pathway: TRICARBOXYLIC ACID (TCA) CYCLE

General Information

Name

TRICARBOXYLIC ACID (TCA) CYCLE

Species

D. melanogaster

Symbol

TCACY

FlyBase ID

FBgg0002103

Date last reviewed

2025-03-20

Number of members

Description

The tricarboxylic acid (TCA) cycle is a central metabolic process that occurs in mitochondria. It consists of a cyclic series of chemical reactions that harness high-energy electrons from nutrients to produce energy (ATP). Each turn of the TCA cycle oxidizes one acetyl-CoA to two CO2 molecules and yields one GTP or ATP and 6 electrons in the form of four reducing equivalents (three NADH and one FADH2). Then, these electron carriers transfer their electrons onto the electron transport chain (ETC) complexes to generate ATP in a process known as oxidative phosphorylation (OXPHOS). The TCA cycle intermediates can also be used as precursors for the biosynthesis of amino acids, fatty acids and porphyrins and for gluconeogenesis. (Adapted from PMID:36581208).

Notes

Cs2 is a paralog of Cs1 and is specifically expressed in testis. As there is no functional information, Cs2 is not included in the gene list. mAcon2 is a paralog of mAcon1 and is specifically expressed in testis. As there is no functional information, mAcon2 is not included in the gene list. CG3483 and CG32026 are paralogs of Idh3a and are specifically expressed in testis. As there is no functional information, CG3483 and CG32026 are not included in the gene list. Ogdh2 is a paralog of Ogdh1 and is specifically expressed in testis. As there is no functional information, Ogdh2 is not included in the gene list. Scsα2 is a paralog of Scsα1 and is specifically expressed in testis. As there is no functional information, Scsα2 is not included in the gene list. SdhAL, SdhBL and SdhCL are paralogs of SdhA, SdhB and SdhC, respectively and are specifically expressed in testis. As there is no functional information, SdhAL, SdhBL and SdhCL are not included in the gene list. Fum2, Fum3 and Fum4 are paralogs of Fum1 and are specifically expressed in testis. As there is no functional information, Fum2, Fum3 and Fum4 are not included in the gene list. CG10748 and CG10749 are paralogs of Mdh2 and are specifically expressed in testis. As there is no functional information, CG10748 and CG10749 are not included in the gene list.

Source Material

The TRICARBOXYLIC ACID (TCA) CYCLE Gene Group has been compiled using the following publication(s): González Morales et al., 2023, Duncan et al., 2017, Quan et al., 2017, Ugur et al., 2017, Van Vranken et al., 2014, Cheng et al., 2013, and Wang et al., 2010 .

Key Gene Ontology (GO) terms

Biological Process

tricarboxylic acid cycle

Cellular Component

mitochondrion

Related Gene Groups

Parent group(s)

ENERGY METABOLISM

Other related group(s)

OXIDATIVE PHOSPHORYLATION

PYRUVATE DECARBOXYLATION TO ACETYL-COA

GO Causal Activity Model (GO-CAM)