FlyBase Allele Report: Dmel\Atg6[00096]

(Zheng et al., 2023, Shravage et al., 2013, Shen and Ganetzky, 2009, Scott et al., 2004, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Saitoh et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999)

lethal - all die before end of pupal stage | recessive

(Scott et al., 2004)

partially lethal - majority die

partially lethal - majority die | recessive

(Berkeley Drosophila Genome Project, 1993.6.1)

some die during pupal stage | recessive

(Scott et al., 2004)

Phenotype Manifest In

Detailed Description

Statement

Reference

Heterozygosity for Atg6⁰⁰⁰⁹⁶ reverts the resistance to paraquat toxicity seen in puc^E69/+ animals.

(Wu et al., 2009)

Mutants show variable disruption of autophagy.

(Scott et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Atg6⁰⁰⁰⁹⁶ is an enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^elav-C155, hiw^UAS.fl

(Shen and Ganetzky, 2009)

Atg6⁰⁰⁰⁹⁶ is an enhancer of decreased cell growth rate phenotype of Scer\GAL4^elav-C155, hiw^UAS.fl

(Shen and Ganetzky, 2009)

Atg6[+]/Atg6⁰⁰⁰⁹⁶ is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, bchs^EP2299

(Simonsen et al., 2007)

Suppressor of

Statement

Reference

bsk^DN.UAS, Atg6⁰⁰⁰⁹⁶/Atg6⁰⁰⁰⁹⁶ is a suppressor of decreased cell number | somatic clone | larval stage phenotype of Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹

(Zheng et al., 2023)

Atg6⁰⁰⁰⁹⁶/Atg6⁰⁰⁰⁹⁶ is a suppressor | partially of decreased cell number | somatic clone | adult stage phenotype of Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹

(Zheng et al., 2023)

Atg6⁰⁰⁰⁹⁶/Atg6⁰⁰⁰⁹⁶ is a suppressor | partially of increased cell death | somatic clone | larval stage phenotype of Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹

(Zheng et al., 2023)

Atg6[+]/Atg6⁰⁰⁰⁹⁶ is a suppressor of abnormal oxidative stress response | dominant phenotype of puc^E69

(Wu et al., 2009)

NOT Suppressor of

Statement

Reference

Atg6⁰⁰⁰⁹⁶/Atg6⁰⁰⁰⁹⁶ is a non-suppressor of decreased cell number | somatic clone | larval stage phenotype of scrib¹

(Zheng et al., 2023)

Atg6⁰⁰⁰⁹⁶/Atg6⁰⁰⁰⁹⁶ is a non-suppressor of increased cell death | somatic clone | adult stage phenotype of scrib¹

(Zheng et al., 2023)

Atg6⁰⁰⁰⁹⁶, Scer\GAL4^GMR.PU is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

Other

Statement

Reference

Atg6[+]/Atg6⁰⁰⁰⁹⁶, Hsap\MAPT^GMR.Ex.PJ has visible phenotype

(Ambegaokar and Jackson, 2011)

Phenotype Manifest In

Enhancer of

Statement

Reference

Atg6⁰⁰⁰⁹⁶ is an enhancer of neuromuscular junction phenotype of Scer\GAL4^elav-C155, hiw^UAS.fl

(Shen and Ganetzky, 2009)

Atg6[+]/Atg6⁰⁰⁰⁹⁶ is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, bchs^EP2299

(Simonsen et al., 2007)

Suppressor of

Statement

Reference

Atg6⁰⁰⁰⁹⁶/Atg6⁰⁰⁰⁹⁶ is a suppressor | partially of eye-antennal disc | somatic clone phenotype of Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹

(Zheng et al., 2023)

bsk^DN.UAS, Atg6⁰⁰⁰⁹⁶/Atg6⁰⁰⁰⁹⁶ is a suppressor of eye-antennal disc | somatic clone phenotype of Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹

(Zheng et al., 2023)

NOT Suppressor of

Statement

Reference

Atg6⁰⁰⁰⁹⁶/Atg6⁰⁰⁰⁹⁶ is a non-suppressor of eye-antennal disc | somatic clone phenotype of scrib¹

(Zheng et al., 2023)

Atg6⁰⁰⁰⁹⁶, Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

Other

Statement

Reference

Atg6[+]/Atg6⁰⁰⁰⁹⁶, Hsap\MAPT^GMR.Ex.PJ has eye phenotype

(Ambegaokar and Jackson, 2011)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of Atg6⁰⁰⁰⁹⁶ does not suppress the apoptosis seen in flies overexpressing hid.

(Ambegaokar and Jackson, 2011)

The modest neuromuscular undergrowth seen upon expression of hiw^Scer\UAS.fl under the control of Scer\GAL4^elav-C155 is enhanced in a Atg6⁰⁰⁰⁹⁶ heterozygous background.

(Shen and Ganetzky, 2009)

Xenogenetic Interactions

Statement

Reference

One copy of Atg6⁰⁰⁰⁹⁶ produces a necrotic plaque phenotype in the eyes of flies expressing Hsap\MAPT^GMR.Ex.PJ.

Expression of Atg6⁰⁰⁰⁹⁶ does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

(Ambegaokar and Jackson, 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11487

ry⁵⁰⁶ P{PZ}Atg6⁰⁰⁰⁹⁶/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

Comments

Complements: Syx1A¹⁰⁶⁶⁰. Complements: l(3)rQ303^rQ303.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

ATG6⁰⁰⁰⁹⁶

(Wu et al., 2009)

Atg6⁰⁰⁰⁹⁶

(Zheng et al., 2023, Cunningham et al., 2020, Saitoh et al., 2015, Ambegaokar and Jackson, 2011, Wu et al., 2009)

atg6⁰⁰⁰⁹⁶

(Simonsen et al., 2007)

l(3)00096

(Spradling et al., 1999)

l(3)00096⁰⁰⁰⁹⁶

(BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project, 1993.6.1)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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