FB2025_05 , released December 11, 2025
Gene: Dmel\Atg6
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General Information
Symbol
Dmel\Atg6
Species
D. melanogaster
Name
Autophagy-related 6
Annotation Symbol
CG5429
Feature Type
protein_coding_gene
FlyBase ID
FBgn0264325
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Summary
Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Beclin-1, beclin, l(3)00096, Beclin1, Autophagy-specific gene 6

Key Links
Genomic Location
Cytogenetic map
95D10-95D10
Sequence location
Recombination map
3-82
RefSeq locus
NT_033777 REGION:24049180..24050782
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (22 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables small GTPase binding
inferred from direct assay
(Takáts et al., 2021)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables phosphatidylinositol 3-kinase binding
inferred from biological aspect of ancestor with PANTHER:PTN000298965
(GO Reference Genome Project, 2011-)
enables protein-macromolecule adaptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000298965
(GO Reference Genome Project, 2011-)
Biological Process (16 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
involved_in autophagy
inferred from mutant phenotype
(Shravage et al., 2013)
involved_in cellular response to starvation
inferred from mutant phenotype
(Zirin et al., 2013)
involved_in defense response to Gram-negative bacterium
inferred from high throughput mutant phenotype
(Cronin et al., 2009)
involved_in endocytosis
inferred from mutant phenotype
(Shravage et al., 2013)
involved_in glycophagy
inferred from mutant phenotype
(Zirin et al., 2013)
involved_in hemopoiesis
inferred from mutant phenotype
(Shravage et al., 2013)
involved_in larval midgut cell programmed cell death
inferred from mutant phenotype
(Xu et al., 2015, Chang et al., 2013)
involved_in macroautophagy
inferred from mutant phenotype
(Xu et al., 2015, Chang et al., 2013, Juhász et al., 2008)
inferred from genetic interaction with FLYBASE:Pi3K59F; FB:FBgn0015277
(Juhász et al., 2008)
involved_in negative regulation of innate immune response
inferred from high throughput mutant phenotype
(Cronin et al., 2009)
involved_in neuron remodeling
inferred from mutant phenotype
(Issman-Zecharya and Schuldiner, 2014)
involved_in protein secretion
inferred from mutant phenotype
(Shravage et al., 2013)
involved_in response to oxidative stress
inferred from mutant phenotype
(Wu et al., 2009)
inferred from genetic interaction with FLYBASE:puc; FB:FBgn0243512
(Wu et al., 2009)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in autophagosome assembly
inferred from biological aspect of ancestor with PANTHER:PTN000298965
(GO Reference Genome Project, 2011-)
involved_in autophagy
inferred from electronic annotation with InterPro:IPR007243
(InterPro Project Members, 2004-)
involved_in cellular response to nitrogen starvation
inferred from biological aspect of ancestor with PANTHER:PTN000298965
(GO Reference Genome Project, 2011-)
involved_in late endosome to vacuole transport
inferred from biological aspect of ancestor with PANTHER:PTN000298965
(GO Reference Genome Project, 2011-)
involved_in mitophagy
inferred from biological aspect of ancestor with PANTHER:PTN000298965
(GO Reference Genome Project, 2011-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
part_of phosphatidylinositol 3-kinase complex, class III, type I
inferred from direct assay
(Juhász et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in phagophore assembly site
inferred from biological aspect of ancestor with PANTHER:PTN000298965
(GO Reference Genome Project, 2011-)
part_of phosphatidylinositol 3-kinase complex, class III, type II
inferred from biological aspect of ancestor with PANTHER:PTN000298965
(GO Reference Genome Project, 2011-)
part_of phosphatidylinositol 3-kinase complex, class III, type I
inferred from biological aspect of ancestor with PANTHER:PTN000298965
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the beclin family. (Q9VCE1)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
AUTOPHAGY-RELATED GENES -
The Autophagy-related genes (Atg), characterized extensively in yeast, are a set of approximately twenty evolutionarily conserved genes required for autophagy. Autophagy (specifically, macroautophagy) is the process of bulk degradation of cytoplasmic material. It takes place by the assembly of a double membrane vesicle, the autophagosome, which delivers cargo to the lysosome for recycling. (Adapted from FBrf0219844 and FBrf020902).
AUTOPHAGY-SPECIFIC PHOSPHATIDYLINOSITOL 3-KINASE COMPLEX -
The autophagy-specific phosphatidylinositol 3-kinase complex generates PI3-phosphate (PI3P) at the PAS (phagophore assembly site/preautophagosomal structure). (Adapted from FBrf0219844 and PMID:23999079).
Protein Function (UniProtKB)
Plays a central role in autophagy.
(UniProt, Q9VCE1)
Summary (Interactive Fly)

a component of the Vps34 lipid kinase complex that is required for the formation of PI3P - functions in vesicle trafficking including autophagy and endocytosis - involved in stress, metabolic and immune signaling pathways - binds to Rab18 - promotes niche occupancy by bam mutant stem cells - Zonda, an Atg6 interactor, is critically required for starvation-induced autophagy - UVRAG interacts with Atg6 and together they promote autophagy - required for endolysosomal degradation and epithelial polarity during wing development

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Atg6 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VCE1)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Atg6-RA
FBtr0084590
NM_142952
1493
422
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Atg6-PA
FBpp0083975
48.9
422
4.53
Q9VCE1
NP_651209
AAF56227
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Rab18, preferentially binding to the GTP-bound form.

(UniProt, Q9VCE1)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Atg6 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.12

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of phosphatidylinositol 3-kinase complex, class III, type I
inferred from direct assay
(Juhász et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Atg6 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Atg6
Transgenic constructs containing regulatory region of Atg6
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(3R)Exel6197
(Ryder, 2004.4.26)
Gene not disrupted in
Df(3R)crb87-4
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
lethal - all die before end of pupal stage (with Df(3R)Exel6197)
lethal - all die before end of pupal stage | recessive
partially lethal - majority die
partially lethal - majority die | recessive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4Ddc.PL
abnormal neuroanatomy | adult stage | somatic clone
abnormal neuroanatomy | adult stage | somatic clone - tissue specific
abnormal neuroanatomy | P-stage
abnormal neurophysiology | adult stage | somatic clone - tissue specific
abnormal oxidative stress response | RU486 conditional, with Scer\GAL4αTub84B.Switch.PK
abnormal size | P-stage, with Scer\GAL4NP0001
abnormal starvation stress response | larval stage, with Scer\GAL4Cg.PU
abnormal visual behavior | adult stage | somatic clone - tissue specific
increased occurrence of cell division | adult stage, with Scer\GAL4esg.PU
melanotic mass phenotype | recessive | third instar larval stage
short lived, with Scer\GAL4Ddc.PL
some die during pupal stage (with Df(3R)Exel6197)
some die during pupal stage | recessive
some die during third instar larval stage (with Df(3R)Exel6197)
visible | adult stage, with Scer\GAL4GMR.PU
Phenotype manifest in
Allele
adult brain | adult stage | somatic clone - tissue specific
adult midgut epithelium, with Scer\GAL4esg.PU
autolysosome
autophagosome
autophagosome |  :chemical conditional | nutrition conditional, with Scer\GAL4Mef2.PR
axon | P-stage
cytoplasmic vesicle | early third instar larval stage, with Scer\GAL4Cg.PA
embryonic/larval fat body | larval stage
embryonic/larval fat body | larval stage, with Scer\GAL4Cg.PU
embryonic/larval fat body | larval stage | somatic clone
embryonic/larval midgut | P-stage, with Scer\GAL4NP0001
eye, with Scer\GAL4GMR.PU
eye photoreceptor cell | adult stage | somatic clone - tissue specific
eye photoreceptor cell | P-stage | somatic clone - tissue specific
fat cell | early third instar larval stage | somatic clone, with Scer\GAL4Cg.PA
filopodium | P-stage | increased number | somatic clone - tissue specific
gamma Kenyon cell | adult stage | somatic clone
gastric caecum | P-stage, with Scer\GAL4NP0001
major mitochondrial derivative, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
mitochondrial derivative | fertilized egg stage, with Scer\GAL4VP16.mat.αTub67C
nephrocyte, with Scer\GAL4Ugt36A1.PK
ommatidium, with Scer\GAL4GMR.PU
retina | adult stage | somatic clone - tissue specific
synapse | adult stage | increased number | somatic clone - tissue specific
synapse | P-stage | increased number
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (3)
Hsap\BECN1
14 of 14
Yes
Yes
Hsap\BECN2
9 of 14
No
Yes
Hsap\PHLDB2
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (3)
Rnor\Becn1
14 of 14
Yes
Yes
Rnor\Becn2
8 of 14
No
Yes
Rnor\Cdc42bpa
1 of 14
No
No
Mus musculus (laboratory mouse) (3)
Mmus\Becn1
14 of 14
Yes
Yes
Mmus\Becn2
5 of 14
No
Yes
Mmus\Cdc42bpa
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (1)
Xtro\becn1
11 of 13
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\becn1
14 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\bec-1
14 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP003858
12 of 12
Yes
Yes
Agam\AgaP_AGAP012793
4 of 12
No
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\ATG6
12 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\VPS30
12 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\atg6
11 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Atg6. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 6 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    BECN1; beclin 1
    14 of 14
    604378
        BECN2; beclin 2
        9 of 14
        615687
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Summary of Genetic Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Atg6
            enhanceable
            Buffy
            (M'Angale and Staveley, 2016)
            Atg6
            enhanceable
            Coq2
            (Zhu et al., 2017)
            Atg6
            suppressible
            ptc
            (Issman-Zecharya and Schuldiner, 2014)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            bchs
            enhanceable
            Atg6
            (Simonsen et al., 2007)
            Coq2
            enhanceable
            Atg6
            (Zhu et al., 2017)
            Dcp-1
            suppressible
            Atg6
            (Kim et al., 2010)
            dom
            enhanceable
            Atg6
            (Kwon et al., 2013)
            hiw
            enhanceable
            Atg6
            (Shen and Ganetzky, 2009)
            Ire1
            suppressible
            Atg6
            (Zheng et al., 2023)
            Prosβ2
            enhanceable
            Atg6
            (Pandey et al., 2007)
            puc
            suppressible
            Atg6
            (Wu et al., 2009)
            scrib|Ire1
            suppressible
            Atg6
            (Zheng et al., 2023)
            scrib|Ire1
            suppressible
            Atg6|bsk
            (Zheng et al., 2023)
            shrb
            suppressible
            Atg6
            (Shravage et al., 2013)
            Tom40
            suppressible
            Atg6
            (Liu et al., 2018)
            Vps25
            suppressible
            Atg6
            (Shravage et al., 2013)
            External Data
            Subunit Structure (UniProtKB)
            Interacts with Rab18, preferentially binding to the GTP-bound form.
            (UniProt, Q9VCE1 )
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            External Data
            Linkouts
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map
            3-82
            Cytogenetic map
            95D10-95D10
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            95D10-95D10
            Limits computationally determined from genome sequence between P{PZ}l(3)0468404684 and P{PZ}Atg600096
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            95D10-95D11
            (determined by in situ hybridisation)
            (Spradling et al., 1999)
            95D10-95D11
            (BDGP Project Members, 1994-1999)
            Experimentally Determined Recombination Data
            Location

            3-82

            (FlyBase, 2016)

            3-82.5

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (9)
            Genomic Clones (20)
            cDNA Clones (24)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 
                  Other Comments

                  Atg6 is required for the normal clearance of the paternal mitochondrial derivatives in developing embryos.

                  (Politi et al., 2014)
                  Relationship to Other Genes
                  Source for database merge of

                  Source for merge of: CG5429 l(3)00096

                  (Scott et al., 2004)

                  Source for merge of: Atg6 beclin

                  (FlyBase, 1992-)
                  Additional comments

                  FlyBase curator comment: Correspondence with author Naps revealed that 'Beclin1' = 'CG5429'.

                  (Naps and Neufeld, 2008)
                  Nomenclature History
                  Source for database identify of

                  Source for identity of: Atg6 CG5429

                  (Scott et al., 2004)
                  Nomenclature comments
                  Etymology
                  Synonyms and Secondary IDs (14)
                  Reported As
                  Symbol Synonym
                  ATG6
                  (Im et al., 2025, Song et al., 2020, Xia et al., 2016, Oh et al., 2015, Kourtis and Tavernarakis, 2009, Wu et al., 2009, Lee et al., 2007)
                  Atg6
                  (Bradic and Rewitz, 2025, Krejčová et al., 2025, Li et al., 2025, Tyszka et al., 2025, Tzou et al., 2025, Zhang et al., 2025, Umargamwala et al., 2024, Xu et al., 2024, Demir and Kacew, 2023, Zheng et al., 2023, Zhou et al., 2023, Ciesielski et al., 2022, Kakanj et al., 2022, Lim and Hyun, 2022, Weina et al., 2022, Xu et al., 2022, Cox et al., 2021, Evans et al., 2021, Rosendo Machado et al., 2021, Barthez et al., 2020, Cunningham et al., 2020, Denton et al., 2020, Du et al., 2020, Gohel et al., 2020, Haghi et al., 2020, Kiral et al., 2020, Rodriguez-Fernandez et al., 2020, Sênos Demarco et al., 2020, Xu et al., 2020, Bhattacharjee et al., 2019, Khezri and Rusten, 2019, Meltzer et al., 2019, Sênos Demarco et al., 2019, Tettamanti and Casartelli, 2019, Xu et al., 2019, Yan et al., 2019, Zhang et al., 2019, Billes et al., 2018, Kuo et al., 2018, Liu et al., 2018, Na et al., 2018, O'Keefe and Denton, 2018, Bali and Shravage, 2017, Galluzzi et al., 2017, Hu et al., 2017.6.13, Kim et al., 2017, Lei et al., 2017, Lo Piccolo et al., 2017, Manent et al., 2017, Péan et al., 2017, Transgenic RNAi Project members, 2017-, Zhu et al., 2017, Kuleesha et al., 2016, Lőrincz et al., 2016, M'Angale and Staveley, 2016, Tracy et al., 2016, Denton et al., 2015, Kim et al., 2015, Pérez et al., 2015, Saitoh et al., 2015, Xu et al., 2015, Zhang and Baehrecke, 2015, Zirin et al., 2015, Banreti et al., 2014, Issman-Zecharya and Schuldiner, 2014, Lee et al., 2014, Mulakkal et al., 2014, Nelson et al., 2014, Bai et al., 2013, Chang et al., 2013, Denton et al., 2013, Moy and Cherry, 2013, Owusu-Ansah et al., 2013, Shravage et al., 2013, Zirin et al., 2013, Érdi et al., 2012, Garcia et al., 2012, Gistelinck et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Wang et al., 2012, Ambegaokar and Jackson, 2011, Chang and Neufeld, 2010, Demontis and Perrimon, 2010, Kadandale et al., 2010, Kim et al., 2010, Midorikawa et al., 2010, Zirin and Perrimon, 2010, Cronin et al., 2009, Juhász et al., 2008, Liu and Lehmann, 2008, Martin et al., 2007, Monserrate et al., 2007)
                  BECN1
                  (Wu et al., 2019)
                  Beclin-1
                  (Tzou et al., 2025, Wu et al., 2024, Kadandale et al., 2010)
                  Beclin1
                  (Lee et al., 2007)
                  CG5429
                  (El Fissi et al., 2024, Érdi et al., 2012, Ni et al., 2011.7.19, Chittaranjan et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Juhász et al., 2008, Laviolette et al., 2005, Gorski et al., 2003, Lee et al., 2003)
                  DmAtg6
                  (Melani et al., 2017, Chittaranjan et al., 2009)
                  atg6
                  (Sun et al., 2025, Joy et al., 2021, Zhao et al., 2021, Singh and Chowdhuri, 2018, Zhao et al., 2018, Melani et al., 2017, Tsakiri et al., 2017, Jain et al., 2015, Joffre et al., 2015, Politi et al., 2014, Kwon et al., 2013, Tsakiri et al., 2013, Fouillet et al., 2012, Midorikawa et al., 2010, Shelly et al., 2009, Shen and Ganetzky, 2009, Pandey et al., 2007, Pandey et al., 2007, Simonsen et al., 2007)
                  beclin
                  (Shin and Yoo, 2007)
                  dAtg6
                  (Li et al., 2016)
                  l(3)00096
                  (Spradling et al., 1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project, 1993.6.1)
                  Name Synonyms
                  Autophagy-related 6
                  Autophagy-specific gene 6
                  (Scott et al., 2004)
                  Beclin-1
                  (Pandey et al., 2018, Zhang and Baehrecke, 2015)
                  Beclin1
                  (Sênos Demarco et al., 2020, Juhász et al., 2008, Naps and Neufeld, 2008)
                  beclin
                  (Shin and Yoo, 2007)
                  beclin 1
                  (Shin et al., 2013)
                  Secondary FlyBase IDs
                  • FBgn0010709
                  • FBgn0039144
                  • FBgn0086211
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 41 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  Linkouts
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  References (190)