FlyBase Gene Report: Dmel\Atg6

General Information

Symbol

Dmel\Atg6

Species

D. melanogaster

Name

Autophagy-related 6

Annotation Symbol

CG5429

Feature Type

protein_coding_gene

FlyBase ID

FBgn0264325

Gene Model Status

Stock Availability

8 publicly available

Gene Snapshot

Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

l(3)00096, beclin, Beclin1, Autophagy-specific gene 6, DmAtg6

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:24,049,180..24,050,782 [-]

Recombination map

3-82

RefSeq locus

NT_033777 REGION:24049180..24050782

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (18 terms)

Molecular Function (0 terms)

There is no information supporting a Molecular Function term for this gene. (Based on a review of available data on: 2014-06-12 )

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (15 terms)

Terms Based on Experimental Evidence (11 terms)

CV Term

Evidence

References

involved_in autophagy

inferred from mutant phenotype

(Xu et al., 2015, Chang et al., 2013, Shravage et al., 2013, Juhász et al., 2008)

inferred from genetic interaction with FLYBASE:Pi3K59F; FB:FBgn0015277

(Juhász et al., 2008)

involved_in cellular response to starvation

inferred from mutant phenotype

(Zirin et al., 2013)

involved_in defense response to Gram-negative bacterium

inferred from high throughput mutant phenotype

(Cronin et al., 2009)

involved_in endocytosis

inferred from mutant phenotype

(Shravage et al., 2013)

involved_in glycophagy

inferred from mutant phenotype

(Zirin et al., 2013)

involved_in hemopoiesis

inferred from mutant phenotype

(Shravage et al., 2013)

involved_in larval midgut cell programmed cell death

inferred from mutant phenotype

(Xu et al., 2015, Chang et al., 2013)

involved_in negative regulation of innate immune response

inferred from high throughput mutant phenotype

(Cronin et al., 2009)

involved_in neuron remodeling

inferred from mutant phenotype

(Issman-Zecharya and Schuldiner, 2014)

involved_in protein secretion

inferred from mutant phenotype

(Shravage et al., 2013)

involved_in response to oxidative stress

inferred from mutant phenotype

(Wu et al., 2009)

inferred from genetic interaction with FLYBASE:puc; FB:FBgn0243512

(Wu et al., 2009)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in autophagosome assembly

inferred from biological aspect of ancestor with PANTHER:PTN000298965

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in cellular response to nitrogen starvation

inferred from biological aspect of ancestor with PANTHER:PTN000298965

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in late endosome to vacuole transport

inferred from biological aspect of ancestor with PANTHER:PTN000298965

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of cytokinesis

inferred from electronic annotation with InterPro:IPR032913

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of phosphatidylinositol 3-kinase complex, class III, type I

inferred from direct assay

(Juhász et al., 2008)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in phagophore assembly site

inferred from biological aspect of ancestor with PANTHER:PTN000298965

(assigned by GO_Central )

(Gaudet et al., 2011)

part_of phosphatidylinositol 3-kinase complex, class III, type II

inferred from biological aspect of ancestor with PANTHER:PTN000298965

(assigned by GO_Central )

(Gaudet et al., 2011)

part_of phosphatidylinositol 3-kinase complex, class III, type I

inferred from biological aspect of ancestor with PANTHER:PTN000298965

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

AUTOPHAGY-RELATED GENES

AUTOPHAGY-SPECIFIC PHOSPHATIDYLINOSITOL 3-KINASE COMPLEX

Protein Family (UniProt)

Belongs to the beclin family. (Q9VCE1)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

AUTOPHAGY-RELATED GENES -: The Autophagy-related genes (Atg), characterized extensively in yeast, are a set of approximately twenty evolutionarily conserved genes required for autophagy. Autophagy (specifically, macroautophagy) is the process of bulk degradation of cytoplasmic material. It takes place by the assembly of a double membrane vesicle, the autophagosome, which delivers cargo to the lysosome for recycling. (Adapted from FBrf0219844 and FBrf020902).
AUTOPHAGY-SPECIFIC PHOSPHATIDYLINOSITOL 3-KINASE COMPLEX -: The autophagy-specific phosphatidylinositol 3-kinase complex generates PI3-phosphate (PI3P) at the PAS (phagophore assembly site/preautophagosomal structure). (Adapted from FBrf0219844 and PMID:23999079).

Gene Model and Products

Number of Transcripts

1

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\Atg6 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

(Shin and Yoo, 2007)

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0084590

1493

422

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0083975

48.9

422

4.53

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Q9VCE1

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Atg6 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Atg6_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of phosphatidylinositol 3-kinase complex, class III, type I

inferred from direct assay

(Juhász et al., 2008)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Atg6 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Atg6

View exonic expression by tissue for Dmel\Atg6

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264325

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5429

Images

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Atg6

Transgenic constructs containing regulatory region of Atg6

Deletions and Duplications ( 2 )

Disrupted in

(Ryder, 2004.4.26)

Not disrupted in

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

Atg6⁰⁰⁰⁹⁶

lethal - all die before end of pupal stage (with Df(3R)Exel6197)

Atg6¹

lethal - all die before end of pupal stage | recessive

Atg6⁰⁰⁰⁹⁶

partially lethal - majority die

Atg6⁰⁰⁰⁹⁶

partially lethal - majority die | recessive

Atg6⁰⁰⁰⁹⁶

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Atg6^GD11647

viable, with Scer\GAL4^Mef2.PR

Atg6^GD11647

viable, with Scer\GAL4^pnr-MD237

Atg6^GD11647

viable, with Scer\GAL4^tin.CΔ4

Atg6^GD11647

Other Phenotypes

Allele

endocytosis defective | somatic clone

Atg6¹

increased occurrence of cell division | adult stage, with Scer\GAL4^esg.PU

Atg6^HMS01483

locomotor behavior defective | adult stage | progressive, with Scer\GAL4^Ddc.PL

Atg6^GD11647

melanotic mass phenotype | recessive | third instar larval stage

Atg6¹

neuroanatomy defective | adult stage | somatic clone

Atg6¹

oxidative stress response defective | RU486 conditional, with Scer\GAL4^{αTub84B.Switch.PK}

Atg6^UAS.Tag:HA

short lived, with Scer\GAL4^Ddc.PL

Atg6^GD11647

size defective | P-stage, with Scer\GAL4^NP0001

some die during pupal stage (with Df(3R)Exel6197)

Atg6¹

some die during pupal stage | recessive

Atg6⁰⁰⁰⁹⁶

some die during third instar larval stage (with Df(3R)Exel6197)

Atg6¹

starvation stress response defective | larval stage, with Scer\GAL4^Cg.PU

Atg6^JF02897

visible | adult stage, with Scer\GAL4^GMR.PU

Atg6^GD11647

Phenotype manifest in

Allele

adult midgut epithelium, with Scer\GAL4^esg.PU

Atg6^HMS01483

Atg6¹

Atg6¹

autophagosome | :chemical conditional | nutrition conditional, with Scer\GAL4^Mef2.PR

Atg6^HMS01483

cytoplasmic vesicle | early third instar larval stage, with Scer\GAL4^Cg.PA

Atg6^HMS01483

embryonic/larval fat body | larval stage

Atg6¹

embryonic/larval fat body | larval stage, with Scer\GAL4^Cg.PU

Atg6^JF02897

embryonic/larval fat body | larval stage | somatic clone

Atg6¹

embryonic/larval midgut | P-stage, with Scer\GAL4^NP0001

eye, with Scer\GAL4^GMR.PU

Atg6^GD11647

fat cell | early third instar larval stage | somatic clone, with Scer\GAL4^Cg.PA

Atg6^HMS01483

gamma Kenyon cell | adult stage | somatic clone

Atg6¹

gastric caecum | P-stage, with Scer\GAL4^NP0001

major mitochondrial derivative, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

Atg6^HMS01483

ommatidium, with Scer\GAL4^GMR.PU

Atg6^GD11647

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

15 of 15

Yes

Yes

8 of 15

No

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

14 of 15

Yes

Yes

3 of 15

No

Yes

Rattus norvegicus (Norway rat) (2)

13 of 13

Yes

Yes

7 of 13

No

Yes

Xenopus tropicalis (Western clawed frog) (1)

13 of 12

Yes

Yes

Danio rerio (Zebrafish) (1)

14 of 15

Yes

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

14 of 15

Yes

Yes

Arabidopsis thaliana (thale-cress) (1)

9 of 9

Yes

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

13 of 15

Yes

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

11 of 12

Yes

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091908I1 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00013512

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915053W )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY009498

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_14018

Mayetiola destructor

Hessian fly

Mdes\Mdes001333

Aedes aegypti

Yellow fever mosquito

Anopheles darlingi

American malaria mosquito

Adar\ADAC004651

Anopheles gambiae

Malaria mosquito

Agam\AGAP012793

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ011087

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04BS )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA000092

Danaus plexippus

Monarch butterfly

Dple\DPOGS205543-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL011273

Apis florea

Little honeybee

Aflo\2447624836

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000c87

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG011696

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM420440

Rhodnius prolixus

Kissing bug

Rpro\RPRC002353

Rhodnius prolixus

Kissing bug

Rpro\RPRC006439

Cimex lectularius

Bed bug

Clec\CLEC006228

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI004000

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_07723

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_17966

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X048D )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR014345

Ixodes scapularis

Black-legged tick

Isca\ISCW014200

Stegodyphus mimosarum

African social velvet spider

Smim\KFM67317.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur11g02400

Tetranychus urticae

Two-spotted spider mite

Turt\tetur574g00010

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_128719

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0COC )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000009608

Gallus gallus

Domestic chicken

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

exacerbates Kennedy's disease

modeled by Hsap\AR^Q52.UAS

(Pandey et al., 2007)

exacerbates primary coenzyme Q10 deficiency 1

modeled by Coq2^HMC03492

(Zhu et al., 2017)

modeled by Coq2^JF02380

(Zhu et al., 2017)

exacerbates nephrotic syndrome

modeled by Coq2^HMC03492

(Zhu et al., 2017)

modeled by Coq2^JF02380

(Zhu et al., 2017)

exacerbates Parkinson's disease

modeled by Hsap\SNCA^UAS.cFa

(M'Angale and Staveley, 2016)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

BECN1; beclin 1

15 of 15

BECN2; beclin 2

8 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

(Hu et al., 2017.6.13)

pull down, autoradiography

(Melani et al., 2017)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(M'Angale and Staveley, 2016)

suppressible

(Issman-Zecharya and Schuldiner, 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Simonsen et al., 2007)

suppressible

(Kim et al., 2010)

enhanceable

(Kwon et al., 2013)

enhanceable

(Shen and Ganetzky, 2009)

enhanceable

(Pandey et al., 2007)

suppressible

(Wu et al., 2009)

suppressible

(Shravage et al., 2013)

suppressible

(Liu et al., 2018)

suppressible

(Shravage et al., 2013)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0264325

MIST (genetic) - An integrated Molecular Interaction Database

Atg6

MIST (protein-protein) - An integrated Molecular Interaction Database

Atg6

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-82

Cytogenetic map

Sequence location

3R:24,049,180..24,050,782 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

95D10-95D10

Limits computationally determined from genome sequence between P{PZ}l(3)04684⁰⁴⁶⁸⁴ and P{PZ}Atg6⁰⁰⁰⁹⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

95D10-95D11

(determined by in situ hybridisation)

(Spradling et al., 1999)

95D10-95D11

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

3-82

(FlyBase, 2016)

3-82.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

28060

y¹ v¹; P{TRiP.JF02897}attP2

80830

y¹, v¹; P{TKO.GS04638}attP40

35741

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01483}attP2

11487

ry⁵⁰⁶ P{PZ}Atg6⁰⁰⁰⁹⁶/TM3, ry^RK Sb¹ Ser¹

F003089

M{UAS-Atg6.ORF.3xHA.GW}ZH-86Fb

v110197

P{KK102460}VIE-260B

v22122

w¹¹¹⁸; P{GD11647}v22122

v22123

w¹¹¹⁸; P{GD11647}v22123

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (24)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD35669

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0264325

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42850

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Atg6 CG5429

(Scott et al., 2004)

Source for database merge of

Source for merge of: CG5429 l(3)00096

(Scott et al., 2004)

Source for merge of: Atg6 beclin

(FlyBase, 1992-)

Additional comments

FlyBase curator comment: Correspondence with author Naps revealed that 'Beclin1' = 'CG5429'.

(Naps and Neufeld, 2008)

Other Comments

Atg6 is required for the normal clearance of the paternal mitochondrial derivatives in developing embryos.

(Politi et al., 2014)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 32 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42850

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VCE1

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264325

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0264325

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Atg6_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5429

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42850

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC009816

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG5429

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0264325

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (genetic) - An integrated Molecular Interaction Database

Atg6

MIST (protein-protein) - An integrated Molecular Interaction Database

Atg6

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

ATG6

(Xia et al., 2016, Oh et al., 2015, Kourtis and Tavernarakis, 2009, Wu et al., 2009, Lee et al., 2007)

Atg6

(Barthez et al., 2020, Kiral et al., 2020, Sênos Demarco et al., 2020, Bhattacharjee et al., 2019, Khezri and Rusten, 2019, Meltzer et al., 2019, Sênos Demarco et al., 2019, Tettamanti and Casartelli, 2019, Xu et al., 2019, Yan et al., 2019, Zhang et al., 2019, Billes et al., 2018, Kuo et al., 2018, Liu et al., 2018, Na et al., 2018, O'Keefe and Denton, 2018, Galluzzi et al., 2017, Hu et al., 2017.6.13, Kim et al., 2017, Lei et al., 2017, Lo Piccolo et al., 2017, Manent et al., 2017, Péan et al., 2017, Transgenic RNAi Project members, 2017-, Zhu et al., 2017, Kuleesha et al., 2016, Lőrincz et al., 2016, M'Angale and Staveley, 2016, Tracy et al., 2016, Denton et al., 2015, Kim et al., 2015, Xu et al., 2015, Zhang and Baehrecke, 2015, Zirin et al., 2015, Banreti et al., 2014, Issman-Zecharya and Schuldiner, 2014, Lee et al., 2014, Mulakkal et al., 2014, Nelson et al., 2014, Bai et al., 2013, Chang et al., 2013, Denton et al., 2013, Moy and Cherry, 2013, Owusu-Ansah et al., 2013, Shravage et al., 2013, Zirin et al., 2013, Érdi et al., 2012, Garcia et al., 2012, Gistelinck et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Wang et al., 2012, Ambegaokar and Jackson, 2011, Chang and Neufeld, 2010, Demontis and Perrimon, 2010, Kadandale et al., 2010, Kim et al., 2010, Midorikawa et al., 2010, Zirin and Perrimon, 2010, Cronin et al., 2009, Juhász et al., 2008, Liu and Lehmann, 2008, Martin et al., 2007, Monserrate et al., 2007)

BECN1

(Wu et al., 2019)

Beclin-1

(Kadandale et al., 2010)

Beclin1

(Lee et al., 2007)

CG5429

(Érdi et al., 2012, Ni et al., 2011.7.19, Chittaranjan et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Juhász et al., 2008, Laviolette et al., 2005, Gorski et al., 2003, Lee et al., 2003)

DmAtg6

(Melani et al., 2017, Chittaranjan et al., 2009)

atg6

(Singh and Chowdhuri, 2018, Melani et al., 2017, Tsakiri et al., 2017, Jain et al., 2015, Joffre et al., 2015, Politi et al., 2014, Kwon et al., 2013, Tsakiri et al., 2013, Fouillet et al., 2012, Shelly et al., 2009, Shen and Ganetzky, 2009, Pandey et al., 2007, Pandey et al., 2007, Simonsen et al., 2007)

beclin

(Shin and Yoo, 2007)

dAtg6

(Li et al., 2016)

l(3)00096

(Spradling et al., 1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project, 1993.6.1)

Name Synonyms

Autophagy-related 6

Autophagy-specific gene 6

(Scott et al., 2004)

Beclin-1

(Zhang and Baehrecke, 2015)

Beclin1

(Sênos Demarco et al., 2020, Juhász et al., 2008, Naps and Neufeld, 2008)

beclin

(Shin and Yoo, 2007)

beclin 1

(Shin et al., 2013)

Secondary FlyBase IDs

FBgn0010709
FBgn0039144
FBgn0086211

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (137)