synaptic protein - B-box zinc finger superfamily - a negative regular of synaptic growth - regulates guidance of sister axons in the mushroom body
Please see the JBrowse view of Dmel\hiw for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
Gene model reviewed during 5.56
Component of an E3 ubiquitin ligase complex composed of hiw, Rae1 and Fsn (PubMed:17697379, PubMed:21874015). Interacts with Rae1; the interaction with Rae1 may protect hiw from autophagy-mediated degradation (PubMed:21874015).
The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners (By similarity).
The tandem cysteine domain region confers threonine specificity and contains the two essential catalytic cysteine residues that relay ubiquitin. It binds four zinc ions in a C5HC7HC2 configuration.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\hiw using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\hiw in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Synaptic overgrowth in hiw mutants requires JNK signalling.
The RING domain of hiw plays an essential role in regulating synaptic function.
hiw dependant ubiquitination has a role in controlling the level of activity of critical regulatory molecules at the synapse.
hiw appears to function as a negative regulator of synaptic growth.
Annotations CG9041, CG9049 merged as CG32592 in release 3 of the genome annotation.
Source for identity of hiw CG9041 CG9049 was sequence comparison ( date:000622 ).
Source for identity of: hiw CG9041 CG9049
