FlyBase Allele Report: Scer\GAL4[NP4132]

General Information

Symbol

Scer\GAL4^NP4132

Species

S. cerevisiae

Name

FlyBase ID

FBal0316788

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

P{GawB}hiw^NP4132

Carried in Construct

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{GawB}hiw^NP4132

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{GawB}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:15,024,404..15,024,404 [-]

(Huang et al., 2012)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal memory, with hiw^GD14101

(Huang et al., 2012)

abnormal memory, with hiw^UAS.fl

(Huang et al., 2012)

abnormal memory, with hiw^ΔRING.UAS

(Huang et al., 2012)

Phenotype Manifest In

Detailed Description

Statement

Reference

Blocking synaptic transmission either during acquisition (during spaced training) or during retrieval (at the time of testing, 24 hours after training) in neurons expressing Scer\GAL4^NP4132 has no effect on aversive long term memory. Long term memory is impaired when synaptic transmission is blocked over the whole consolidation period or in the 12 hour interval 6 hours after completion of spaced training. No impairment is seen when Scer\GAL80^Mef2.mb247 is also present. Learning is unaffected.

Blocking synaptic transmission in Scer\GAL4^NP4132-expressing neurons for the 12 hour interval 6 hours after massed training does not impair anesthesia-resistant (ARM) memory, either in the presence or absence of Scer\GAL80^Mef2.mb247.

Blocking synaptic transmission in Scer\GAL4^NP4132-expressing neurons for 24 hours following training impairs appetitive (association of an odor with sucrose) long term memory. Appetitive long term memory is normal if synaptic transmission is not blocked until 12 hours after training but is defective if it is blocked for the 12 hours immediately after training. Sensorimotor abilities are unchanged compared with controls. No impairment is seen when Scer\GAL80^Mef2.mb247 is also present.

(Huang et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^NP4132, hiw^ΔRING.UAS has abnormal memory phenotype, suppressible by Scer\GAL4^NP4132/wnd^GD13786

(Huang et al., 2012)

Scer\GAL4^NP4132, hiw^ΔRING.UAS has abnormal memory phenotype, suppressible by bsk^DN.UAS/Scer\GAL4^NP4132