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Citation
Wan, H.I., DiAntonio, A., Fetter, R.D., Bergstrom, K., Strauss, R., Goodman, C.S. (2000). Highwire regulates synaptic growth in Drosophila.  Neuron 26(2): 313--329.
FlyBase ID
FBrf0128674
Publication Type
Research paper
Abstract

The formation, stabilization, and growth of synaptic connections are dynamic and highly regulated processes. The glutamatergic neuromuscular junction (NMJ) in Drosophila grows new boutons and branches throughout larval development. A primary walking behavior screen followed by a secondary anatomical screen led to the identification of the highwire (hiw) gene. In hiw mutants, the specificity of motor axon pathfinding and synapse formation appears normal. However, NMJ synapses grow exuberantly and are greatly expanded in both the number of boutons and the extent and length of branches. These synapses appear normal ultrastructurally but have reduced quantal content physiologically. hiw encodes a large protein found at presynaptic terminals. Within presynaptic terminals, HIW is localized to the periactive zone surrounding active zones; Fasciclin II (Fas II), which also controls synaptic growth, is found at the same location.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference
    Aberrations (2)
    Alleles (21)
    Genes (9)
    Insertions (5)
    Experimental Tools (2)
    Transgenic Constructs (2)