FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\raw
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General Information
Symbol
Dmel\raw
Species
D. melanogaster
Name
raw
Annotation Symbol
CG12437
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003209
Gene Model Status
Current
Stock Availability
23 publicly available
Gene Summary
raw (raw) encodes a membrane protein involved in dendrite patterning and the subcellular localization of JNK signalling components. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)
All Summaries
Also Known As

cyr, l(2)06825, cyrano

Key Links
Genomic Location
Cytogenetic map
29E4-29E6
Sequence location
Recombination map
2-33
RefSeq locus
NT_033779 REGION:8709880..8740660
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (14 terms)
Terms Based on Experimental Evidence (14 terms)
CV Term
Evidence
References
involved_in central nervous system development
inferred from mutant phenotype
(Jack and Myette, 1997)
involved_in dorsal closure
inferred from mutant phenotype
(Ríos-Barrera et al., 2015, Liu et al., 1999, Blake et al., 1998)
involved_in ectodermal digestive tract morphogenesis
inferred from mutant phenotype
(Liu et al., 1999)
involved_in germ-band shortening
inferred from mutant phenotype
(Liu et al., 1999)
involved_in gonad development
inferred from mutant phenotype
(Weyers et al., 2011)
involved_in gonad morphogenesis
inferred from mutant phenotype
(Jemc et al., 2012)
involved_in hindgut morphogenesis
inferred from mutant phenotype
(Blake et al., 1998)
involved_in intracellular protein localization
inferred from mutant phenotype
(Blake et al., 1998)
involved_in Malpighian tubule morphogenesis
inferred from mutant phenotype
(Liu et al., 1999, Jack and Myette, 1997)
involved_in morphogenesis of an epithelium
inferred from mutant phenotype
(Liu et al., 1999)
involved_in negative regulation of JNK cascade
inferred from mutant phenotype
(Jemc et al., 2012)
inferred from genetic interaction with FLYBASE:lncRNA:acal; FB:FBgn0283426
(Ríos-Barrera et al., 2015)
involved_in regulation of cell shape
inferred from mutant phenotype
(Blake et al., 1998)
involved_in regulation of Malpighian tubule diameter
inferred from mutant phenotype
(Jack and Myette, 1997)
involved_in salivary gland morphogenesis
inferred from mutant phenotype
(Blake et al., 1998)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in plasma membrane
inferred from direct assay
(Lee et al., 2015)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002190752
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
raw (raw) encodes a membrane protein involved in dendrite patterning and the subcellular localization of JNK signalling components. [Date last reviewed: 2019-09-26]
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
raw: raw
Homozygous lethal; dorsal closure and cuticle differentiation defective.
Summary (Interactive Fly)

a novel gene product required to limit AP-1 activity to leading edge epidermal cells during embryonic dorsal closure

Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\raw for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VLI4)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
raw-RA
FBtr0079746
NM_164836
3754
989
raw-RB
FBtr0079745
NM_080050
3220
805
raw-RC
FBtr0303868
NM_001201804
3954
989
raw-RD
FBtr0340231
NM_001298830
3404
832
raw-RE
FBtr0340232
NM_001298831
4275
989
Additional Transcript Data and Comments
Reported size (kB)

4.3, 3.2 (northern blot)

(Byars et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
raw-PA
FBpp0079348
108.6
989
7.51
Q9VLI4
NP_723416
AAF52706
raw-PB
FBpp0079347
88.8
805
6.67
Q9VLI5
NP_524789
AAF52705
raw-PC
FBpp0292871
108.6
989
7.51
Q9VLI4
NP_001188733
ADV36983
raw-PD
FBpp0309206
91.5
832
5.70
X2J5A2
NP_001285759
AHN54273
raw-PE
FBpp0309207
108.6
989
7.51
Q9VLI4
NP_001285760
AHN54274
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

989 aa isoforms: raw-PA, raw-PC, raw-PE
Additional Polypeptide Data and Comments
Reported size (kDa)

989 (aa)

(Byars et al., 1999)
Comments

raw protein contains a 191aa domain that is repeated within the protein

(Byars et al., 1999)
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\raw using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.41

Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in plasma membrane
inferred from direct assay
(Lee et al., 2015)
Expression Deduced from Reporters
Reporter: P{lacW}rawk08216
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval midgut
(Byars et al., 1999)
Reporter: P{lacW}rawk16002
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval midgut
(Byars et al., 1999)
Reporter: P{PZ}raw02418
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
amnioserosa
(Byars et al., 1999)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\raw in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 37 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 20 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of raw
Transgenic constructs containing regulatory region of raw
Aberrations (Deficiencies and Duplications) ( 14 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal | embryonic stage | recessive
lethal | embryonic stage | rescuable maternal effect
lethal | recessive
lethal - all die during embryonic stage
lethal - all die during embryonic stage | recessive
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal cell number | embryonic stage
abnormal neuroanatomy | cell autonomous | third instar larval stage | conditional, with Scer\GAL4tey-5053A
abnormal neuroanatomy | larval stage, with Scer\GAL4tey-5053A
abnormal neuroanatomy | larval stage, with Scer\GAL4Toll-6-D42
abnormal neuroanatomy | recessive | third instar larval stage | conditional
abnormal neuroanatomy | somatic clone
abnormal neuroanatomy | third instar larval stage | conditional, with Scer\GAL4221
abnormal neuroanatomy | third instar larval stage | conditional (with Df(2L)BSC204)
abnormal neuroanatomy | third instar larval stage | conditional (with raw134.47)
abnormal neuroanatomy | third instar larval stage | conditional (with raw155.27)
abnormal neuroanatomy | third instar larval stage | conditional (with rawdcp-1)
abnormal neurophysiology | third instar larval stage | conditional
abnormal neurophysiology | third instar larval stage | conditional, with Scer\GAL4BG380, rawdcp-1/raw134.47
abnormal neurophysiology | third instar larval stage | conditional, with Scer\GAL4Toll-6-D42, rawdcp-1/raw134.47
abnormal neurophysiology | third instar larval stage | conditional (with raw134.47), with Scer\GAL4BG380, rawUASp.RA
abnormal neurophysiology | third instar larval stage | conditional (with raw134.47), with Scer\GAL4Toll-6-D42, rawUASp.RA
abnormal neurophysiology | third instar larval stage | conditional (with rawdcp-1), with Scer\GAL4BG380, rawUASp.RA
abnormal neurophysiology | third instar larval stage | conditional (with rawdcp-1), with Scer\GAL4Toll-6-D42, rawUASp.RA
flightless, with Scer\GAL4Mef2.PR
increased cell death | embryonic stage
increased cell death | embryonic stage, with Scer\GAL469B
majority die during embryonic stage
some die during embryonic stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
axon
axon | cell autonomous | third instar larval stage | conditional, with Scer\GAL4tey-5053A
axon | third instar larval stage | conditional
axon | third instar larval stage | conditional (with Df(2L)BSC204)
axon | third instar larval stage | conditional (with raw134.47)
axon | third instar larval stage | conditional (with raw155.27)
axon | third instar larval stage | conditional (with rawdcp-1)
dendrite | somatic clone
dendrite | third instar larval stage | conditional, with Scer\GAL4221
denticle
distal axon | larval stage, with Scer\GAL4tey-5053A
embryo | dorsal
embryo | dorsal closure stage
embryonic/first instar larval cuticle
embryonic/first instar larval cuticle | dorsal
embryonic/first instar larval cuticle | ventral
embryonic/larval cuticle
embryonic/larval hindgut | embryonic stage
embryonic/larval midgut | embryonic stage
embryonic/larval motor neuron | cell autonomous | third instar larval stage | conditional, with Scer\GAL4tey-5053A
embryonic/larval motor neuron | larval stage, with Scer\GAL4tey-5053A
embryonic/larval motor neuron | larval stage, with Scer\GAL4Toll-6-D42
embryonic/larval motor neuron | third instar larval stage | conditional
embryonic/larval motor neuron | third instar larval stage | conditional (with Df(2L)BSC204)
embryonic/larval motor neuron | third instar larval stage | conditional (with raw134.47)
embryonic/larval motor neuron | third instar larval stage | conditional (with raw155.27)
embryonic/larval motor neuron | third instar larval stage | conditional (with rawdcp-1)
embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4Toll-6-D42
embryonic/larval neuromuscular junction | third instar larval stage | conditional
embryonic/larval neuromuscular junction | third instar larval stage | conditional, with Scer\GAL4BG380, rawdcp-1/raw134.47
embryonic/larval neuromuscular junction | third instar larval stage | conditional, with Scer\GAL4Toll-6-D42, rawdcp-1/raw134.47
embryonic/larval neuromuscular junction | third instar larval stage | conditional (with raw134.47), with Scer\GAL4BG380, rawUASp.RA
embryonic/larval neuromuscular junction | third instar larval stage | conditional (with raw134.47), with Scer\GAL4Toll-6-D42, rawUASp.RA
embryonic/larval neuromuscular junction | third instar larval stage | conditional (with rawdcp-1), with Scer\GAL4BG380, rawUASp.RA
embryonic/larval neuromuscular junction | third instar larval stage | conditional (with rawdcp-1), with Scer\GAL4Toll-6-D42, rawUASp.RA
embryonic/larval salivary gland | embryonic stage
embryonic cardioblast
embryonic epidermis
embryonic epidermis | dorsal
embryonic head
embryonic Malpighian tubule
embryonic midgut constriction
embryonic myoblast
embryonic pericardial cell
germline cell | embryonic stage 15 (with raw134.47)
germline cell | embryonic stage 15 (with raw155.27)
germline cell | embryonic stage (with raw134.47)
germline cell | embryonic stage (with raw155.27)
gonad | embryonic stage (with raw134.47)
gonad | embryonic stage (with raw155.27)
gonadal sheath proper primordium | embryonic stage (with raw134.47)
gonadal sheath proper primordium | embryonic stage (with raw155.27)
larval digestive system | embryonic stage
larval dorsal hair
larval dorsal multidendritic neuron ddaE | third instar larval stage, with Scer\GAL4221
larval dorsal multidendritic neuron ddaE | third instar larval stage | conditional, with Scer\GAL4221
larval multidendritic class IV neuron | somatic clone
larval multidendritic class IV neuron | third instar larval stage | conditional
male germline cell | embryonic stage (with raw134.47)
male germline cell | embryonic stage (with raw155.27)
Malpighian tubule
mesoderm | dorsal
mesoderm | dorsal, with Scer\GAL469B
mesonotum, with Scer\GAL4pnr-MD237
microtubule plus-end | third instar larval stage, with Scer\GAL4221
mitotic domain 1 | extended germ band stage
neuron
presumptive embryonic/larval central nervous system
presumptive embryonic/larval peripheral nervous system
trichogen cell, with Scer\GAL4pnr-MD237
ventral denticle belt | absent | embryonic stage
ventral denticle belt | absent | embryonic stage, with Scer\GAL469B
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (0)
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (0)
Mus musculus (laboratory mouse) (0)
Xenopus tropicalis (Western clawed frog) (0)
Danio rerio (Zebrafish) (0)
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\olrn-1
6 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP002736
9 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:raw. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Interaction
    References
    rawk01021
    exacerbates  tauopathy
    modeled by Hsap\MAPTUAS.cWa
    (Feuillette et al., 2020)
    rawk03514
    exacerbates  tauopathy
    modeled by Hsap\MAPTUAS.cWa
    (Feuillette et al., 2020)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    raw - trc
    anti tag coimmunoprecipitation, anti tag western blot
    (Lee et al., 2015)
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    raw
    suppressible
    aop
    (Byars et al., 1999)
    raw
    suppressible
    bsk
    (Jemc et al., 2012)
    raw
    suppressible
    hiw
    (Hao et al., 2019)
    raw
    suppressible
    Jra
    (Hao et al., 2019, Jemc et al., 2012, Byars et al., 1999)
    raw
    suppressible
    kay
    (Waller and Collins, 2023, Hao et al., 2019)
    raw
    suppressible
    lncRNA:acal
    (Ríos-Barrera et al., 2015)
    raw
    suppressible
    mew|mys
    (Lee et al., 2015)
    raw
    suppressible
    p53
    (Yang and Su, 2011)
    raw
    suppressible
    Sarm
    (Waller and Collins, 2023)
    raw
    enhanceable
    shg
    (Jemc et al., 2012)
    raw
    suppressible
    shg
    (Jemc et al., 2012)
    raw
    suppressible
    Tak1
    (Yang and Su, 2011)
    raw
    suppressible
    tkv
    (Yang and Su, 2011)
    raw
    suppressible
    trc
    (Lee et al., 2015)
    raw
    enhanceable
    trc
    (Lee et al., 2015)
    raw
    suppressible
    zip
    (Blake et al., 1999)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    lncRNA:acal
    enhanceable
    raw
    (Ríos-Barrera et al., 2015)
    slpr
    suppressible
    raw
    (Polaski et al., 2006)
    Su(var)3-3
    suppressible
    raw
    (Eliazer et al., 2014)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-33
    Cytogenetic map
    29E4-29E6
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    29E4-29E6
    Limits computationally determined from genome sequence between P{lacW}l(2)k04003k04003 and P{PZ}tai01351
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    29E5-29E6
    (Byars, 1999.9.13, Prokopenko, 1999.8.5, Prokopenko, 1999.11.25)
    29F1-29F2
    (determined by in situ hybridisation)
    (Spradling et al., 1999, Perrimon et al., 1996)
    29E5-29E6
    46F1--2
    (BDGP Project Members, 1994-1999)
    Experimentally Determined Recombination Data
    Location

    2-33

    (FlyBase, 2016)

    2-28.9

    (Comeron et al., 2012)

    2-19

    (Liu et al., 1999, Tearle and Nusslein-Volhard, 1987)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (23)
    Genomic Clones (27)
    cDNA Clones (76)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

        (Boutros et al., 2004)

        Area matching Drosophila EST AI403747.

        (Davies, 2001.3.15)

        raw is required for the restriction of JNK signaling to leading edge epidermal cells during dorsal closure and for the proper development of the amnioserosa.

        (Byars et al., 1999)

        raw is required for the proper shape of tubular epithelial tissues in Drosophila.

        (Jack and Myette, 1997)

        The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.

        (Perrimon et al., 1996)
        Relationship to Other Genes
        Source for database merge of

        Source for merge of: raw l(2)06825 cyr l(2)k03514

        (Byars et al., 1999)

        Source for merge of: raw CG9321 CG12437

        (Bayraktaroglu, 2000.8.7)
        Additional comments
        Nomenclature History
        Source for database identify of
        Nomenclature comments
        Etymology
        Synonyms and Secondary IDs (10)
        Reported As
        Symbol Synonym
        CG12437
        (National Institute of Genetics Fly Stocks, 2022-, Hassan et al., 2018, Neuert et al., 2017, Hosono et al., 2015, Schertel et al., 2013, Keleman et al., 2009.8.5, Ni et al., 2008)
        CG9321
        (Gorski et al., 2003)
        Raw
        (Meyer et al., 2024, Rui, 2024, Rui et al., 2020, Zhou et al., 2017, Ríos-Barrera and Riesgo-Escovar, 2013)
        cyr
        (Prokopenko, 1999.8.5, Prokopenko, 1999.8.5, Prokopenko, 1999.8.5, Prokopenko, 1999.8.5, Prokopenko, 1999.8.5, Prokopenko, 1999.8.5, Prokopenko, 1999.11.25, Kania et al., 1995)
        ensh
        (Weyers et al., 2011)
        l(2)06825
        (Spradling et al., 1999, Perrimon et al., 1996, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)
        l(2)k03514
        raw
        (Balakireva et al., 2024, Reim, 2024.4.19, Perlegos et al., 2022, Cohen et al., 2020, Feuillette et al., 2020, Rui et al., 2020, Wang et al., 2020, Hao et al., 2019, Harbison et al., 2019, Hassan et al., 2018, Luong et al., 2018, Fochler et al., 2017, Neuert et al., 2017, Carbone et al., 2016, Clandinin and Owens, 2016-, Lee et al., 2015, Ríos-Barrera et al., 2015, Ashwal-Fluss et al., 2014, Eliazer et al., 2014, Aleksic et al., 2013, Bonke et al., 2013, Huang et al., 2013, Humphreys et al., 2013, Schertel et al., 2013, Jemc et al., 2012, Weyers et al., 2011, Yang and Su, 2011, Zhang et al., 2010, Bates et al., 2008, Christensen and Cook, 2006.8.30, Christensen and Cook, 2006.8.30, Christensen and Cook, 2006.8.30, Friedman and Perrimon, 2006, Polaski et al., 2006)
        Name Synonyms
        cyrano
        (Prokopenko and Bellen, 2000, Prokopenko, 1999.11.25)
        ensheathment defects
        (Weyers et al., 2011)
        raw
        (Wieschaus and Nüsslein-Volhard, 2016)
        Secondary FlyBase IDs
        • FBgn0010627
        • FBgn0015377
        • FBgn0022218
        • FBgn0032063
        • FBgn0032064
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 78 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        References (125)