FlyBase Allele Report: Dmel\raw[k03514]

General Information

Symbol

Dmel\raw^k03514

Species

D. melanogaster

Name

FlyBase ID

FBal0045482

Feature type

allele

Associated gene

Dmel\raw

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Byars et al., 1999, Kania et al., 1995)

some die during embryonic stage | recessive

(Byars et al., 1999, Kania et al., 1995)

Phenotype Manifest In

axon

(Kania et al., 1995)

embryo | dorsal closure stage

(Byars et al., 1999)

mitotic domain 1 | extended germ band stage

(Kania et al., 1995)

neuron

(Kania et al., 1995)

presumptive embryonic/larval peripheral nervous system

(Kania et al., 1995)

Detailed Description

Statement

Reference

Homozygous embryos arrest development due to defects in dorsal closure.

(Byars et al., 1999)

Homozygous embryos exhibit elongated neuronal cell bodies and mild germ band retraction defects. Embryos also exhibit thicker than wild type axon bundles and minor pathfinding defects.

(Kania et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

raw^k03514/raw[+] is an enhancer of visible | adult stage phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Feuillette et al., 2020)

Phenotype Manifest In

Enhancer of

Statement

Reference

raw^k03514/raw[+] is an enhancer of eye phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Feuillette et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

raw⁰⁶⁸²⁵

(Byars et al., 1999)

raw²

(Byars et al., 1999)

raw¹

(Byars et al., 1999)

raw⁰²⁴¹⁸

(Byars et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

10532

y¹ w^67c23; raw^k03514 P{lacW}Fpps^k03514/CyO

Notes on Origin

Discoverer

Separable from: Fpps^k03514.

(FlyBase, 1996-)

Separable from: P{lacW}Fpps^k03514. The lethality of the "l(2)k03514" chromosome (caused by raw^k03514) is separable from the P{lacW}Fpps^k03514 insertion.

(Spradling, 1999.12.9)

Separable from: P{lacW}Fpps^k03514.

(Spradling et al., 1999, Kania et al., 1995)

Comments

This allele was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was discarded from the gene disruption project prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Spradling (spradling@mail1.ciwemb.edu).

Complements: l(2)k05103^k05103. Complements: l(2)k13403^k13403. Complements: Tapδ^k17005.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

35/14

(Kania et al., 1995)

cyr^35-14

cyr^k03514

(Byars et al., 1999)

l(2)k03514^k03514

raw^k03514

(Feuillette et al., 2020)

Name Synonyms

Secondary FlyBase IDs

FBal0064554

References (7)

Report Sections

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