FlyBase Allele Report: Dmel\raw[2]

General Information

Symbol

Dmel\raw²

Species

D. melanogaster

Name

FlyBase ID

FBal0014433

Feature type

allele

Associated gene

Dmel\raw

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Byars et al., 1999)

Mutagen

ethyl methanesulfonate

(Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

No mutation has been identified in the coding region, suggesting that this is a regulatory mutation.

(Byars et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Ríos-Barrera et al., 2015)

majority die during embryonic stage

(Ríos-Barrera et al., 2015)

Phenotype Manifest In

embryonic/first instar larval cuticle | dorsal

(Byars et al., 1999)

embryonic/larval cuticle

(Ríos-Barrera et al., 2015)

presumptive embryonic/larval peripheral nervous system

(Byars et al., 1999)

Detailed Description

Statement

Reference

raw² mutant embryos exhibit severe cuticle defects, with dorsalized embryos.

(Ríos-Barrera et al., 2015)

The dorsal cuticle is reduced in homozygous embryos and the embryos have upturned tails and curved abdomens. Elongated neuronal cell bodies, thickened axon bundles and fasciculation defects are seen in the peripheral nervous system.

(Byars et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

raw² has lethal phenotype, non-suppressible by acal[+]/lncRNA:acal⁵

(Ríos-Barrera et al., 2015)

raw² has majority die during embryonic stage phenotype, non-suppressible by acal[+]/lncRNA:acal⁵

(Ríos-Barrera et al., 2015)

raw² has lethal phenotype, non-suppressible by lncRNA:acal⁵/lncRNA:acal⁵

(Ríos-Barrera et al., 2015)

raw² has majority die during embryonic stage phenotype, non-suppressible by lncRNA:acal⁵/lncRNA:acal⁵

(Ríos-Barrera et al., 2015)

Enhancer of

Statement

Reference

raw² is an enhancer of lethal phenotype of lncRNA:acal⁵

(Ríos-Barrera et al., 2015)

raw² is an enhancer of some die during embryonic stage phenotype of lncRNA:acal⁵

(Ríos-Barrera et al., 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

raw² has embryonic/larval cuticle phenotype, suppressible | partially by lncRNA:acal^UAS.cRa/Scer\GAL4^69B

(Ríos-Barrera et al., 2015)

NOT suppressed by

Statement

Reference

raw² has embryonic/larval cuticle phenotype, non-suppressible by acal[+]/lncRNA:acal⁵

(Ríos-Barrera et al., 2015)

raw² has embryonic/larval cuticle phenotype, non-suppressible by lncRNA:acal⁵/lncRNA:acal⁵

(Ríos-Barrera et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of raw² enhances the embryonic lethality seen in homozygous acal⁵ mutants, with a quarter of embryos phenocopying the dorsalized phenotype seen in raw² alone. acal⁵ does not enhance the homozygous raw² phenotype.

Expression of acal^Scer\UAS.cRa under the control of Scer\GAL4^69B partially suppresses the cuticle dorsalization phenotype seen in raw² mutant embryos.

(Ríos-Barrera et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

raw^k01021

(Byars et al., 1999)

raw⁰²⁴¹⁸

(Byars et al., 1999)

raw^k03514

(Byars et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

raw²

(Ríos-Barrera et al., 2015)

raw^IIF08

(Jack and Myette, 1999)

raw^IIF

(Byars et al., 1999, Tearle and Nusslein-Volhard, 1987)

raw^IIP08

(Jack and Myette, 1997)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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