FlyBase Allele Report: Dmel\lncRNA:acal[5]

General Information

Symbol

Dmel\lncRNA:acal⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0302948

Feature type

allele

Associated gene

Dmel\lncRNA:acal

Associated Insertion(s)

Carried in Construct

Allele class

hypomorphic allele - molecular evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Ríos-Barrera et al., 2015)

Mutagen

ethyl methanesulfonate

(Ríos-Barrera et al., 2015)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

lethal

(Ríos-Barrera et al., 2015)

some die during embryonic stage

(Ríos-Barrera et al., 2015)

some die during larval stage

(Ríos-Barrera et al., 2015)

some die during pupal stage

(Ríos-Barrera et al., 2015)

Phenotype Manifest In

embryonic/larval cuticle

(Ríos-Barrera et al., 2015)

Detailed Description

Statement

Reference

A fraction of acal⁵ mutant embryos exhibit dorsal closure defects, with holes in either the dorsal or anterior ends of the embryo. No other cuticular defects are seen.

(Ríos-Barrera et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

lncRNA:acal⁵ has lethal phenotype, enhanceable by raw²

(Ríos-Barrera et al., 2015)

lncRNA:acal⁵ has some die during embryonic stage phenotype, enhanceable by raw²

(Ríos-Barrera et al., 2015)

Suppressed by

Statement

Reference

lncRNA:acal⁵ has lethal phenotype, suppressible | partially by aop¹

(Ríos-Barrera et al., 2015)

lncRNA:acal⁵ has some die during embryonic stage phenotype, suppressible | partially by aop¹

(Ríos-Barrera et al., 2015)

lncRNA:acal⁵ has lethal phenotype, suppressible | partially by bsk¹

(Ríos-Barrera et al., 2015)

lncRNA:acal⁵ has some die during embryonic stage phenotype, suppressible | partially by bsk¹

(Ríos-Barrera et al., 2015)

Suppressor of

Statement

Reference

acal[+]/lncRNA:acal⁵ is a suppressor of lethal - all die before end of embryonic stage phenotype of aop¹

(Ríos-Barrera et al., 2015)

NOT Suppressor of

Statement

Reference

lncRNA:acal⁵/lncRNA:acal⁵ is a non-suppressor of lethal phenotype of raw²

(Ríos-Barrera et al., 2015)

lncRNA:acal⁵/lncRNA:acal⁵ is a non-suppressor of majority die during embryonic stage phenotype of raw²

(Ríos-Barrera et al., 2015)

acal[+]/lncRNA:acal⁵ is a non-suppressor of lethal phenotype of bsk¹

(Ríos-Barrera et al., 2015)

acal[+]/lncRNA:acal⁵ is a non-suppressor of some die during embryonic stage phenotype of bsk¹

(Ríos-Barrera et al., 2015)

acal[+]/lncRNA:acal⁵ is a non-suppressor of lethal phenotype of raw²

(Ríos-Barrera et al., 2015)

acal[+]/lncRNA:acal⁵ is a non-suppressor of majority die during embryonic stage phenotype of raw²

(Ríos-Barrera et al., 2015)

Other

Statement

Reference

acal[+]/lncRNA:acal⁵, aop¹ has some die during embryonic stage phenotype

(Ríos-Barrera et al., 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

lncRNA:acal⁵ has embryonic/larval cuticle phenotype, suppressible | partially by aop¹

(Ríos-Barrera et al., 2015)

Suppressor of

Statement

Reference

acal[+]/lncRNA:acal⁵ is a suppressor | partially of embryonic/larval cuticle phenotype of aop¹

(Ríos-Barrera et al., 2015)

NOT Suppressor of

Statement

Reference

lncRNA:acal⁵/lncRNA:acal⁵ is a non-suppressor of embryonic/larval cuticle phenotype of raw²

(Ríos-Barrera et al., 2015)

acal[+]/lncRNA:acal⁵ is a non-suppressor of embryonic/larval cuticle phenotype of raw²

(Ríos-Barrera et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

bsk¹ significantly suppresses the dorsal closure defects and lethality seen in homozygous acal⁵ mutant embryos.

One copy of acal⁵ does not suppress the dorsal closure defects and lethality seen in homozygous bsk¹ mutant embryos.

One copy of raw² enhances the embryonic lethality seen in homozygous acal⁵ mutants, with a quarter of embryos phenocopying the dorsalized phenotype seen in raw² alone. acal⁵ does not enhance the homozygous raw² phenotype.

One copy of acal⁵ almost completely rescues the dorsal closure defects and lethality seen in aop¹ mutant embryos.

One copy of aop¹ does not rescue the dorsal closure defects and lethality seen in acal⁵ mutant embryos.

(Ríos-Barrera et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

lncRNA:acal⁵ is partially rescued by lncRNA:acal^UAS.cRa/Scer\GAL4^69B

(Ríos-Barrera et al., 2015)

Comments

Expression of acal^Scer\UAS.cRa under the control of Scer\GAL4^69B results in significant rescue of acal⁵ dorsal closure defects and reduction of embryonic lethality.

Expression of acal^Scer\UAS.cRa under the control of Scer\GAL4^pnr-MD237 rescues acal⁵ dorsal closure defects.

(Ríos-Barrera et al., 2015)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

acal⁵

(Ríos-Barrera et al., 2015)

lncRNA:acal⁵

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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