FlyBase Allele Report: Dmel\bsk[1]

General Information

Symbol

Dmel\bsk¹

Species

D. melanogaster

Name

FlyBase ID

FBal0001321

Feature type

allele

Associated gene

Dmel\bsk

Associated Insertion(s)

Carried in Construct

Also Known As

bsk1

Genomic Maps

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Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

point mutation

2L:10,248,232..10,248,232 [-]

Nucleotide change:

G10248232A

Reported nucleotide change:

G?A

Amino acid change:

G225E | bsk-PB; G225E | bsk-PE; G225E | bsk-PF

Reported amino acid change:

G225E

(Davis, 1996.3.8, Sluss et al., 1996)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

U50965

AAB51187

UniProtKB/Swiss-Prot

P92208

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Amino acid replacement: G225E.

(Davis, 1996.3.8, Sluss et al., 1996)

Mutation is located between subdomains IX and X of the bsk kinase, is conserved in the MAP kinase family and is located in a region required for substrate recognition by JNK protein kinases.

(Sluss et al., 1996)

Nucleotide substitution: G?A.

(Sluss et al., 1996)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Parkinson's disease

CEA

(Inamdar et al., 2014)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates retinitis pigmentosa

modeled by ninaE^P37H, ninaE¹⁷

(Griciuc et al., 2014)

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Hong et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

amnioserosa (with bsk²)

(Wada et al., 2007)

axon | somatic clone

(Bornstein et al., 2015)

embryo | dorsal closure stage

(Lu and Settleman, 1999, Riesgo-Escovar et al., 1996)

embryo | dorsal closure stage | germline clone

(Riesgo-Escovar et al., 1996)

embryo | embryonic stage 14 (with bsk²)

(Wada et al., 2007)

embryonic/first instar larval cuticle | dorsal

(Kadrmas et al., 2004, Wei et al., 2003, Su et al., 1998, Riesgo-Escovar et al., 1996)

embryonic/first instar larval cuticle | dorsal | germline clone

(Riesgo-Escovar et al., 1996)

embryonic dorsal epidermis

(Chen et al., 2002, Hou et al., 1997)

embryonic dorsal epidermis (with bsk²)

(Wada et al., 2007)

embryonic dorsal epidermis (with Df(2L)flp147E)

(Riesgo-Escovar and Hafen, 1997)

embryonic epidermis | dorsal

(Lu and Settleman, 1999, Riesgo-Escovar and Hafen, 1997, Sluss et al., 1996)

filamentous actin (with bsk²)

(Wada et al., 2007)

mitochondrion

(Wang et al., 2019)

mitotic domain 1 | embryonic stage 13 (with bsk²)

(Wada et al., 2007)

mitotic domain 1 | embryonic stage 15 (with bsk²)

(Wada et al., 2007)

Detailed Description

Statement

Reference

bsk¹ heterozygotes do not show obvious thorax defects.

(Sun et al., 2019)

While females with bsk¹ germline clones produced similar amount of eggs as controls, ovaries show decreased mtDNA replication in region 2B and 3 cysts, and eggs show severely decreased levels of mtDNA.

(Wang et al., 2019)

bsk¹ heterozygosity does not significantly affect the mitotic index in the adult midgut epithelium, as compared to controls.

(Nagy et al., 2016)

bsk¹/bsk¹ clones (in adult mushroom body γ lobe) are deficient in axon (but not dendrite) pruning compared to wild type.

(Bornstein et al., 2015)

bsk¹/+ third instar larvae do not show any decrease in the neuromuscular junction bouton number.

(Wong et al., 2015)

bsk¹ heterozygous mutants exhibit extreme sensitivity to 1-octen-3-ol. These flies survive for approximately 15 days when exposed to 0.5ppm 1-octen-3-ol, significantly lower than the 18 days-long survival span observed for exposed wild-type flies.

(Inamdar et al., 2014)

As in wild type, a bsk¹ mutant neuroblast clone in the larval brain maintains a single neuroblast and consists of many neuronal progeny.

(Kuang et al., 2014)

Single cell bsk¹ clones in mushroom bodies have axons with wild type projections.

(Rallis et al., 2010)

bsk¹/bsk² mutant embryos exhibit defective dorsal closure. F-actin cable formation in the peripheral amnioserosa is less prominent and the outer (ventral) edge of the peripheral amnioserosa is able to maintain a higher activity of filopodia.

(Wada et al., 2007)

Approximately 60% of bsk¹ homozygous embryos shows a 'dorsal open' phenotype.

(Kadrmas et al., 2004)

Mutant embryos have dorsal holes in the cuticle.

(Wei et al., 2003)

Homozygous embryos show a weak dorsal-open phenotype.

(Chen et al., 2002)

Homozygotes show a defect in dorsal closure.

(Lu and Settleman, 1999)

Homozygous embryos show defects in dorsal closure.

(Su et al., 1998)

Embryos exhibit a dorsal open phenotype.

(Hou et al., 1997)

Embryonic cuticle is partially closed in the dorsal posterior part. Removal of maternal and zygotic bsk (bsk¹/Df(2L)flp147E) results in a complete dorsal open phenotype.

(Riesgo-Escovar and Hafen, 1997)

Initial phases of dorsal closure are normal, but the first rows under the leading cell row of the dorsal edge show only a partial lengthening cell shape change or no cell shape change at all. The defect is more pronounced in anterior cells. Embryonic cuticle defect is temperature sensitive: At 18^oC egg lays show weaker phenotypes. Embryos derived from germline clones show an extreme dorsal open phenotype, with no cell shape change in leading row cells, and dorsal closure never initiates. This phenotype is rescuable by zygotic bsk⁺. Homozygous clones in the eye reveal no abnormality.

(Riesgo-Escovar et al., 1996)

Mutant embryos show a dorsal hole due to a defect in dorsal closure. Dorsoventral patterning is not defective.

(Sluss et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

bsk¹ has lethal phenotype, non-suppressible by acal[+]/lncRNA:acal⁵

(Ríos-Barrera et al., 2015)

bsk¹ has some die during embryonic stage phenotype, non-suppressible by acal[+]/lncRNA:acal⁵

(Ríos-Barrera et al., 2015)

Enhancer of

Statement

Reference

bsk¹/bsk[+] is an enhancer of visible | adult stage phenotype of Scer\GAL4^pnr.PU, lic^GD7546

(Sun et al., 2019)

bsk¹/bsk[+] is an enhancer of visible phenotype of Pkn^k06808

(Sass and Ostrow, 2014)

bsk¹, BacA\p35^GMR.PH, bsk[+] is an enhancer of increased cell death phenotype of BacA\p35^GMR.PH, Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

bsk¹/bsk[+] is an enhancer of partially lethal - majority die phenotype of slpr^BS06

(Polaski et al., 2006)

bsk¹/bsk[+] is an enhancer of visible phenotype of by²

(Lee et al., 2003)

NOT Enhancer of

Statement

Reference

bsk¹/bsk[+] is a non-enhancer of neuroanatomy defective phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, msn^EP549

(Ruan et al., 2002)

Suppressor of

Statement

Reference

bsk¹/bsk[+] is a suppressor of increased occurrence of cell division | adult stage phenotype of Scer\GAL4^NP5130, Uvrag^HMS01357

(Nagy et al., 2016)

bsk¹ is a suppressor | partially of lethal phenotype of lncRNA:acal⁵

(Ríos-Barrera et al., 2015)

bsk¹ is a suppressor | partially of some die during embryonic stage phenotype of lncRNA:acal⁵

(Ríos-Barrera et al., 2015)

bsk¹/bsk[+] is a suppressor | partially of size defective phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, hep^CA.UAS

(Zhang et al., 2015)

bsk¹/bsk[+] is a suppressor | partially of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, hep^CA.UAS

(Zhang et al., 2015)

bsk¹/bsk[+] is a suppressor | partially of size defective phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, egr^UAS.cIa

(Zhang et al., 2015)

bsk¹/bsk[+] is a suppressor | partially of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, egr^UAS.cIa

(Zhang et al., 2015)

bsk¹/bsk[+] is a suppressor of neurophysiology defective phenotype of ninaE¹⁷, ninaE^P37H

(Griciuc et al., 2014)

bsk¹/bsk[+] is a suppressor of neuroanatomy defective phenotype of ninaE¹⁷, ninaE^P37H

(Griciuc et al., 2014)

bsk¹ is a suppressor | partially of neuroanatomy defective | somatic clone | larval stage phenotype of fzy⁵⁰³²

(Kuang et al., 2014)

bsk¹/bsk[+] is a suppressor of cell migration defective phenotype of Csk^GD9345, Scer\GAL4^ptc-559.1

(Rudrapatna et al., 2014)

bsk¹ is a suppressor of visible phenotype of Daxx^EY09290, Scer\GAL4^Bx-MS1096

(Hwang et al., 2013)

bsk¹/bsk[+] is a suppressor of increased cell death phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

bsk¹/hep^r75 is a suppressor of increased cell death phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

bsk¹/bsk[+] is a suppressor of increased cell death | larval stage phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU

(Hong et al., 2012)

bsk¹/bsk[+] is a suppressor | partially of lethal phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU

(Hong et al., 2012)

bsk¹/bsk[+] is a suppressor of locomotor behavior defective phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU

(Hong et al., 2012)

bsk¹/bsk[+] is a suppressor | partially of visible phenotype of HIV-1\Vpu^UAS.cLa, Scer\GAL4^dpp.blk1

(Marchal et al., 2012)

bsk¹/bsk[+] is a suppressor | partially of chemical resistant phenotype of Scer\GAL4^h.PU, Tn\neoR^UAS.GFP

(Stern et al., 2012)

bsk¹/bsk[+] is a suppressor | partially of visible phenotype of Dref^UAS.cSa, Scer\GAL4^GMR.PS

(Yoshioka et al., 2012)

bsk¹/bsk[+] is a suppressor | partially of visible phenotype of Rab11^mo

(Tiwari and Roy, 2009)

bsk¹/bsk[+] is a suppressor of visible phenotype of flw¹, puc^A251.1F3/puc[+]

(Kirchner et al., 2007)

bsk¹/bsk[+] is a suppressor | partially of lethal | recessive phenotype of flw⁶

(Kirchner et al., 2007)

bsk¹/bsk[+] is a suppressor | partially of visible phenotype of Scer\GAL4^hs.2sev, Tak1^UAS.cMa

(Xue et al., 2007)

bsk¹/bsk[+] is a suppressor | partially of visible phenotype of Rala^35d

(Balakireva et al., 2006)

bsk¹/bsk[+] is a suppressor | partially of visible phenotype of Rala^S25N.cMa.UAS, Scer\GAL4^sca-537.4

(Balakireva et al., 2006)

bsk¹/bsk[+] is a suppressor | partially of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, egr^UAS.cMa

(Geuking et al., 2005)

bsk¹ is a suppressor of visible phenotype of H^Scer\UAS.cMa/H^UAS.cMa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Müller et al., 2005)

bsk¹ is a suppressor of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

bsk¹ is a suppressor of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

bsk¹ is a suppressor of lethal | pupal stage phenotype of Csk^j1D8/Csk^S030003

(Read et al., 2004)

bsk¹ is a suppressor of increased occurrence of cell division phenotype of Csk^j1D8/Csk^S030003

(Read et al., 2004)

bsk¹/bsk[+] is a suppressor of visible phenotype of Scer\GAL4^69B, nmo^c5-1.UAS

(Mirkovic et al., 2002)

bsk¹/bsk[+] is a suppressor | partially of planar polarity defective phenotype of peb¹

(Pickup et al., 2002)

bsk¹/bsk[+] is a suppressor of visible phenotype of Rac1^GMR.PN

(Stronach and Perrimon, 2002)

bsk¹ is a suppressor | partially of lethal | embryonic stage | partially | recessive phenotype of peb³⁰⁸

(Reed et al., 2001)

bsk¹ is a suppressor of planar polarity defective phenotype of Scer\GAL4^hs.2sev, fz^UAS.cAa

(Strutt et al., 1997)

NOT Suppressor of

Statement

Reference

bsk¹/bsk[+] is a non-suppressor of neuroanatomy defective phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, msn^EP549

(Ruan et al., 2002)

Other

Statement

Reference

Trpml¹, bsk¹/bsk[+] has neuroanatomy defective | third instar larval stage phenotype

(Wong et al., 2015)

Csk^GD9345, bsk¹ has lethal phenotype

(Rudrapatna et al., 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

bsk¹ has embryonic dorsal epidermis phenotype, enhanceable by Cka⁰⁵⁸³⁶/Cka⁰⁵⁸³⁶

(Chen et al., 2002)

bsk¹ has embryonic/first instar larval cuticle | dorsal phenotype, enhanceable by msn[+]/msn¹⁰²

(Su et al., 1998)

bsk¹ has embryonic epidermis | dorsal phenotype, enhanceable by Jra^{bZIP.hs.sev.Tag:HA}

(Riesgo-Escovar and Hafen, 1997)

Suppressed by

Statement

Reference

bsk¹ has embryonic/first instar larval cuticle | dorsal phenotype, suppressible | partially by ics^BG02577/ics^BG02577

(Kadrmas et al., 2004)

bsk¹ has embryonic/first instar larval cuticle | dorsal phenotype, suppressible | partially by Sac1[+]/Sac1^L2F

(Wei et al., 2003)

bsk¹ has embryonic epidermis | dorsal phenotype, suppressible by Jra^Asp.hs.sev

(Hou et al., 1997)

bsk¹/Df(2L)flp147E has embryonic epidermis | dorsal phenotype, suppressible by aop^unspecified

(Riesgo-Escovar and Hafen, 1997)

Enhancer of

Statement

Reference

bsk¹/bsk[+] is an enhancer of tergum phenotype of Scer\GAL4^pnr.PU, lic^GD7546

(Sun et al., 2019)

bsk¹/bsk[+] is an enhancer of wing phenotype of Pkn^k06808

(Sass and Ostrow, 2014)

bsk¹/bsk[+] is an enhancer of wing margin bristle phenotype of Pkn^k06808

(Sass and Ostrow, 2014)

bsk¹, BacA\p35^GMR.PH, bsk[+] is an enhancer of eye phenotype of BacA\p35^GMR.PH, Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

bsk¹/bsk[+], Scer\GAL4^hs.2sev is an enhancer of eye phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

bsk¹/bsk[+], Scer\GAL4^hs.2sev is an enhancer of eye phenotype of BacA\p35^GMR.PH, Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

bsk¹/bsk[+] is an enhancer of mesothoracic tergum phenotype of Nf-YA^{dsRNA.231-399.UAS.WIZ}, Scer\GAL4^pnr-MD237

(Yoshioka et al., 2008)

bsk¹/bsk[+] is an enhancer of wing phenotype of by²

(Lee et al., 2003)

bsk¹ is an enhancer of embryonic epidermis | dorsal phenotype of Pkn⁰⁶⁷³⁶

(Lu and Settleman, 1999)

bsk¹ is an enhancer of embryo | dorsal closure stage phenotype of Pkn⁰⁶⁷³⁶

(Lu and Settleman, 1999)

bsk¹ is an enhancer of embryonic epidermis | dorsal phenotype of kay¹

(Riesgo-Escovar and Hafen, 1997)

bsk¹ is an enhancer of embryonic epidermis | dorsal phenotype of kay²

(Riesgo-Escovar and Hafen, 1997)

NOT Enhancer of

Statement

Reference

bsk¹/bsk[+] is a non-enhancer of eye | somatic clone phenotype of gfr¹

(Beam and Moberg, 2010)

bsk¹/bsk[+] is a non-enhancer of photoreceptor cell & axon phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, msn^EP549

(Ruan et al., 2002)

bsk¹ is a non-enhancer of wing phenotype of Scer\GAL4^dpp.PH, eya^UAS.cHa

(Hsiao et al., 2001)

bsk¹ is a non-enhancer of phenotype of Rho1^rev220

(Magie et al., 1999)

Suppressor of

Statement

Reference

bsk¹/bsk[+] is a suppressor of adult midgut epithelium phenotype of Scer\GAL4^NP5130, Uvrag^HMS01357

(Nagy et al., 2016)

bsk¹/bsk[+] is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, hep^CA.UAS

(Zhang et al., 2015)

bsk¹/bsk[+] is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, egr^UAS.cIa

(Zhang et al., 2015)

bsk¹/bsk[+] is a suppressor of rhabdomere of eye photoreceptor cell phenotype of ninaE¹⁷, ninaE^P37H

(Griciuc et al., 2014)

bsk¹ is a suppressor | partially of neuroblast | somatic clone | larval stage phenotype of fzy⁵⁰³²

(Kuang et al., 2014)

bsk¹/bsk[+] is a suppressor of wing disc phenotype of Csk^GD9345, Scer\GAL4^ptc-559.1

(Rudrapatna et al., 2014)

bsk¹ is a suppressor of wing phenotype of Daxx^EY09290, Scer\GAL4^Bx-MS1096

(Hwang et al., 2013)

bsk¹/bsk[+] is a suppressor of eye phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

bsk¹/hep^r75 is a suppressor of eye phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

bsk¹/bsk[+] is a suppressor of eye phenotype of Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Hong et al., 2012)

bsk¹/bsk[+] is a suppressor of germline cell | embryonic stage 15 phenotype of raw^155.27/raw^134.47

(Jemc et al., 2012)

bsk¹/bsk[+] is a suppressor | partially of wing phenotype of HIV-1\Vpu^UAS.cLa, Scer\GAL4^dpp.blk1

(Marchal et al., 2012)

bsk¹/bsk[+] is a suppressor | partially of eye phenotype of Dref^UAS.cSa, Scer\GAL4^GMR.PS

(Yoshioka et al., 2012)

bsk¹/bsk[+] is a suppressor of eye phenotype of Scer\GAL4^GMR.PS, Tg^A.UAS

(Umehara et al., 2010)

bsk¹/bsk[+] is a suppressor of ommatidium phenotype of Scer\GAL4^GMR.PS, Tg^A.UAS

(Umehara et al., 2010)

bsk¹/bsk[+] is a suppressor of interommatidial bristle phenotype of Scer\GAL4^GMR.PS, Tg^A.UAS

(Umehara et al., 2010)

bsk¹/bsk[+] is a suppressor of eye phenotype of hep^{CA.sev.Tag:MYC}

(Baril et al., 2009)

bsk¹/bsk[+] is a suppressor of eye phenotype of Rac1^GMR.PN

(Baril et al., 2009, Stronach and Perrimon, 2002)

bsk¹/bsk[+] is a suppressor | partially of eye phenotype of Rab11^mo

(Tiwari and Roy, 2009)

bsk¹/bsk[+] is a suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Fiehler and Wolff, 2008)

bsk¹/bsk[+] is a suppressor of wing phenotype of flw¹, puc^A251.1F3/puc[+]

(Kirchner et al., 2007)

bsk¹ is a suppressor of phenotype of flw^G0172/flw^G0172

(Kirchner et al., 2007)

bsk¹/bsk[+] is a suppressor | partially of embryonic/larval anterior midgut phenotype of puc^GS16811

(Taniguchi et al., 2007)

bsk^DN.UAS, bsk¹, bsk[+], Scer\GAL4^NP3392 is a suppressor of embryonic/larval anterior midgut phenotype of puc^GS16811

(Taniguchi et al., 2007)

bsk¹/bsk[+] is a suppressor | partially of eye phenotype of Scer\GAL4^hs.2sev, Tak1^UAS.cMa

(Xue et al., 2007)

bsk¹/bsk[+] is a suppressor | partially of microchaeta phenotype of Rala^35d

(Balakireva et al., 2006)

bsk¹/bsk[+] is a suppressor of macrochaeta phenotype of Rala^35d

(Balakireva et al., 2006)

bsk¹/bsk[+] is a suppressor | partially of microchaeta phenotype of Rala^S25N.cMa.UAS, Scer\GAL4^sca-537.4

(Balakireva et al., 2006)

bsk¹/bsk[+] is a suppressor of macrochaeta phenotype of Rala^S25N.cMa.UAS, Scer\GAL4^sca-537.4

(Balakireva et al., 2006)

bsk¹/bsk[+] is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, egr^UAS.cMa

(Geuking et al., 2005)

bsk¹ is a suppressor of eye phenotype of H^Scer\UAS.cMa/H^UAS.cMa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Müller et al., 2005)

bsk¹ is a suppressor of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

bsk¹ is a suppressor of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

bsk¹/bsk[+] is a suppressor of posterior crossvein phenotype of Scer\GAL4^69B, nmo^c5-1.UAS

(Mirkovic et al., 2002)

bsk¹/bsk[+] is a suppressor of wing vein | ectopic phenotype of Scer\GAL4^69B, nmo^c5-1.UAS

(Mirkovic et al., 2002)

bsk¹/bsk[+] is a suppressor | partially of ommatidium phenotype of peb¹

(Pickup et al., 2002)

bsk¹/bsk[+] is a suppressor of ommatidium phenotype of Rac1^GMR.PN

(Stronach and Perrimon, 2002)

bsk¹ is a suppressor of ommatidium phenotype of Rac1^V12.hs.sev

(Fanto et al., 2000)

bsk¹/bsk[+] is a suppressor of scutum & macrochaeta phenotype of Rala^S25N.UAS, Scer\GAL4^sca-537.4

(Sawamoto et al., 1999)

bsk¹ is a suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, fz^UAS.cAa

(Strutt et al., 1997)

NOT Suppressor of

Statement

Reference

bsk¹/bsk[+] is a non-suppressor of eye | somatic clone phenotype of gfr¹

(Beam and Moberg, 2010)

bsk¹/bsk[+] is a non-suppressor of photoreceptor cell & axon phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, msn^EP549

(Ruan et al., 2002)

bsk¹ is a non-suppressor of eye | ectopic phenotype of Scer\GAL4^dpp.blk1, eya^UAS.cHa

(Hsiao et al., 2001)

bsk¹ is a non-suppressor of wing phenotype of Scer\GAL4^dpp.PH, eya^UAS.cHa

(Hsiao et al., 2001)

bsk¹ is a non-suppressor of phenotype of Rho1^rev220

(Magie et al., 1999)

Other

Statement

Reference

Trpml¹, bsk¹/bsk[+] has neuromuscular junction | third instar larval stage phenotype

(Wong et al., 2015)

Trpml¹, bsk¹/bsk[+] has NMJ bouton | third instar larval stage phenotype

(Wong et al., 2015)

RagC-D^EY11726, bsk¹/bsk[+] has neuromuscular junction | third instar larval stage phenotype

(Wong et al., 2015)

RagC-D^EY11726, bsk¹/bsk[+] has NMJ bouton | third instar larval stage phenotype

(Wong et al., 2015)

bsk¹, kay² has follicle cell phenotype

(Dequier et al., 2001)

bsk¹, kay² has oocyte | oogenesis stage S9 phenotype

(Dequier et al., 2001)

bsk¹/bsk[+], kay^S135103 has follicle cell phenotype

(Dequier et al., 2001)

bsk¹/bsk[+], kay^S135103 has oocyte | oogenesis stage S9 phenotype

(Dequier et al., 2001)

bsk¹/bsk[+], kay² has follicle cell phenotype

(Dequier et al., 2001)

bsk¹/bsk[+], kay² has oocyte | oogenesis stage S9 phenotype

(Dequier et al., 2001)

bsk¹, kay^S135103 has follicle cell phenotype

(Dequier et al., 2001)

bsk¹, kay^S135103 has oocyte | oogenesis stage S9 phenotype

(Dequier et al., 2001)

bsk¹/bsk[+], msn¹⁰² has embryonic/first instar larval cuticle | dorsal phenotype

(Su et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

bsk¹ heterozygosity suppresses the increased mitotic index in the adult midgut epithelium induced by the adulthood-only expression of Uvrag^HMS01357 under the control of Scer\GAL4^esg-NP5130 (and Gal80[ts], for the temporal control of expression).

(Nagy et al., 2016)

A bsk¹ heterozygous background is sufficient to ameliorate the lipid droplet accumulation displayed in sicily^E mutants.

A bsk¹ heterozygous background is sufficient to ameliorate the lipid droplet accumulation displayed in Aats-met^FB mutants.

A bsk¹ heterozygous background is sufficient to ameliorate the lipid droplet accumulation displayed in Marf^B mutants.

(Liu et al., 2015)

bsk¹ significantly suppresses the dorsal closure defects and lethality seen in homozygous acal⁵ mutant embryos.

One copy of acal⁵ does not suppress the dorsal closure defects and lethality seen in homozygous bsk¹ mutant embryos.

(Ríos-Barrera et al., 2015)

Trpml¹/+,bsk¹/+ double heterozygotes show decreased number of NMJ boutons in third instar larvae compared to either Trpml¹/+ or bsk¹/+ single heterozygotes.

RagC-D^EY11726/+,bsk¹/+ double heterozygotes show decreased number of NMJ boutons in third instar larvae compared to either RagC-D^EY11726/+ or bsk¹/+ single heterozygotes.

(Wong et al., 2015)

Retinal degeneration and light-response defects are strongly suppressed in ninaE^P37H, ninaE¹⁷, bsk¹/+ flies.

(Griciuc et al., 2014)

bsk¹ partially suppresses the larval neuroblast proliferation defects seen in fzy⁵⁰³² mutant clones.

(Kuang et al., 2014)

A bsk¹ heterozygous mutant background suppresses the actin remodelling and subsequent basolateral invasion of epithelial cells seen in flies expressing Csk^GD9345 in a stripe of cells at the anterior/posterior boundary of the larval wing disc under the control of Scer\GAL4^ptc-559.1.

(Rudrapatna et al., 2014)

The Pkn^k06808 wing phenotype is enhanced by bsk¹/+.

(Sass and Ostrow, 2014)

The reduced wing phenotype caused by expression of DLP^EY09290 under the control of Scer\GAL4^Bx-MS1096 is suppressed by bsk¹.

(Hwang et al., 2013)

bsk¹/+ suppresses the frequency of ensheathment defects in raw^134.47/raw^155.27 mutants.

(Jemc et al., 2012)

The rough eye phenotype caused by expression of Dref^Scer\UAS.cSa under the control of Scer\GAL4^GMR.PS is weakly but significantly suppressed by bsk¹/+.

(Yoshioka et al., 2012)

The enlarged eye phenotype seen in mosaic animals in which the eye is homozygous for gfr¹ is not modified by bsk¹/+.

(Beam and Moberg, 2010)

A bsk¹/+ background suppressed the rough eye phenotype found upon expression of Tg^A.Scer\UAS under the control of Scer\GAL4^GMR.PS.

(Umehara et al., 2010)

The eye defects seen in Rab11^mo homozygotes are partially suppressed by bsk¹/+.

(Tiwari and Roy, 2009)

The cleft notum phenotype caused by expression of Nf-YA^{dsRNA.231-399.Scer\UAS.WIZ} under the control of Scer\GAL4^pnr-MD237 is enhanced by bsk¹/+.

(Yoshioka et al., 2008)

The wing defects seen in flw¹/Y ; puc^A251.1F3/+ flies are suppressed to wild type by bsk¹/+.

(Kirchner et al., 2007)

bsk¹/+ significantly suppresses the defects in left-right asymmetry of the anterior midgut that are seen in homozygous puc^GS16811 embryos.

Expression of bsk^DN.Scer\UAS under the control of Scer\GAL4^Gap1-NP3392 significantly suppresses the defects in left-right asymmetry of the anterior midgut that are seen in homozygous puc^GS16811 embryos. This suppression is stronger if the embryos are also carrying bsk¹/+.

81% of homozygous late stage 15 embryos show left-right asymmetry of tilting of the nuclei of the circular visceral muscle (CVM), as occurs in wild-type embryos at this stage. However, 14% of the mutant embryos show no difference between the tilting of the nuclei of the CVM cells on the right and left sides of the presumptive first midgut constriction and 5% show an inversion of the normal asymmetry, with nuclei in the left-ventral region being tilted more than those in the right-ventral region.

(Taniguchi et al., 2007)

Heterozygosity for bsk¹ partially suppresses the mutant eye phenotype caused by expression of Tak1^Scer\UAS.cMa under the control of Scer\GAL4^hs.2sev.

(Xue et al., 2007)

Trans-heterozygotic combination between lkb1^X5 and bsk¹ induces a significant dorsal open phenotype in unhatched first instar larvae.

(Lee et al., 2006)

Shows no interaction with Mpk2¹.

(Craig et al., 2004)

Homozygosity for ics^BG02577 suppresses the bsk¹ 'dorsal open' phenotype, reducing its incidence from approximately 60% to approximately 30%.

(Kadrmas et al., 2004)

The frequency of dorsal holes in the cuticle seen in bsk¹ embryos is partially suppressed by Sac1^L2F/+. bsk¹ shows no genetic interactions with Sac1²¹⁰⁷ or Sac1^BG02228.

(Wei et al., 2003)

The weak dorsal-open phenotype seen in homozygous bsk¹ embryos is enhanced by Cka⁰⁵⁸³⁶/Cka⁰⁵⁸³⁶.

(Chen et al., 2002)

Heterozygosity for bsk¹ can suppress the wing-vein defects, as well as wing shape and size defects seen in Scer\GAL4^69B, nmo^{c5-1.Scer\UAS} adults.

(Mirkovic et al., 2002)

The defects in photoreceptor cell projection patterns seen in larvae overexpressing msn^EP549 under the control of Scer\GAL4^GMR.PF are not affected by one copy of bsk¹.

(Ruan et al., 2002)

Mosaic egg chambers in which the follicle cells are homozygous for kay² in a bsk¹/+ background degenerate during stage 9 and show a complete failure of posteriorwards migration of the main body follicle cells (migration of the border cells appears unaffected). Mosaic egg chambers in which the follicle cells are homozygous for kay^S135103 in a bsk¹/+ background degenerate during stage 9 and show a complete failure of posteriorwards migration of the main body follicle cells (migration of the border cells appears unaffected).

(Dequier et al., 2001)

The proportion of eya^Scer\UAS.cHa; Scer\GAL4^dpp.PH flies with blistered wings (76%) is relatively unaffected by heterozygosity for bsk¹ (69%), as is the proprotion with only mild wing defects 24% compared to (31%). (All data from experiments with a single, 'strong' P{UAS-eya.H} insertion; n=approximately 300 in each case).

(Hsiao et al., 2001)

When bsk¹ fathers are crossed with Pkn⁰⁶⁷³⁶ germline clone mothers, 76% of the embryos showed a dorsal closure phenotype, an enhancement of the dorsal closure phenotype caused by Pkn⁰⁶⁷³⁶ germline clones alone.

(Lu and Settleman, 1999)

bsk¹/+ msn¹⁰²/+ embryos often have a dorsal open phenotype, in contrast to bsk¹ or msn¹⁰² single heterozygotes, which rarely show this phenotype.

(Su et al., 1998)

The bsk¹ dorsal open phenotype can be significantly rescued by heat induced expression of Jra^Asp.hs.sev.

(Hou et al., 1997)

Phenotype is enhanced by heat induced expression of Jra^{bZIP.hs.sev.T:Ivir\HA1}. Loss of a functional copy of aop suppresses the bsk¹/Df(2L)flp147E dorsal closure phenotype.

(Riesgo-Escovar and Hafen, 1997)

Xenogenetic Interactions

Statement

Reference

A bsk¹/+ background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A hep^r75 bsk¹ background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies. Quantification of the ommatidia density suggests that ~47% of spreading apoptosis in R cells can be rescued by a hep^r75 bsk¹ double mutant background.

A bsk¹ heterozygous background, in the presence of BacA\p35^GMR.PH, generates additional rescue of the Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS eye phenotype compared to BacA\p35^GMR.PH alone.

(Yang et al., 2013)

bsk¹/+ partially suppresses the wing defects caused by expression of HIV-1\Vpu^Scer\UAS.cLa under the control of Scer\GAL4^dpp.blk1.

(Marchal et al., 2012)

The ability of animals expressing Tn\neoR^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^h.PU to survive in the presence of a concentration of G418 which is lethal to wild-type controls is partially suppressed if they are also heterozygous for bsk¹.

(Stern et al., 2012)

The neuronal degeneration phenotype and decreased survival of animals expressing Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 is modestly suppressed in a bsk¹/+ mutant background, but the effect is not statistically significant.

(Maher et al., 2011)

Complementation and Rescue Data

Fails to complement

Partially rescued by

bsk¹ is partially rescued by bsk^hs.PS

(Sluss et al., 1996)

Comments

The dorsal hole defect, though not embryonic lethality, can be partly rescued by bsk^hs.PS.

(Sluss et al., 1996)

Images (0)

Mutant

Wild-type

Stocks (2)

3088

106832

Notes on Origin

Discoverer

Comments

Cuticle phenotypes reveal an allelic series: bsk^J27 < bsk¹ < bsk² < bsk^flp147E.

(Riesgo-Escovar et al., 1996)

External Crossreferences and Linkouts ( 3 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

U50965

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAB51187

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P92208

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

Bsk1

(Griciuc et al., 2014)

Bsk1^LOF

(Griciuc et al., 2014)

basket^IIJ

(Arora et al., 1995)

bsk1

(Griciuc et al., 2014, Sluss et al., 1996)

bsk1^LOF

(Griciuc et al., 2014)

bsk¹

(Maier et al., 2019, Sun et al., 2019, Wang et al., 2019, Li et al., 2018, Kenmoku et al., 2017, Nagy et al., 2016, Zhang et al., 2016, Bornstein et al., 2015, Liu et al., 2015, Ríos-Barrera et al., 2015, Wong et al., 2015, Zhang et al., 2015, Inamdar et al., 2014, Kuang et al., 2014, Rudrapatna et al., 2014, Sass and Ostrow, 2014, Schulman et al., 2014, Hwang et al., 2013, Nowak et al., 2013, Yang et al., 2013, Hong et al., 2012, Jemc et al., 2012, Kapfhamer et al., 2012, Marchal et al., 2012, Stern et al., 2012, Yoshioka et al., 2012, Maher et al., 2011, Beam and Moberg, 2010, Rallis et al., 2010, Umehara et al., 2010, Baril et al., 2009, Tiwari and Roy, 2009, Fiehler and Wolff, 2008, Yoshioka et al., 2008, Kirchner et al., 2007, Neuman-Silberberg, 2007, Taniguchi et al., 2007, Wada et al., 2007, Xue et al., 2007, Balakireva et al., 2006, Christensen and Cook, 2006.8.30, Lee et al., 2006, Polaski et al., 2006, Mace et al., 2005, Sano et al., 2005, Kadrmas et al., 2004)

bsk^IIJ04

bsk^IIJ

(Tearle and Nusslein-Volhard, 1987)

jun/bsk¹

(Craig et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (87)

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