Expression of fzScer\UAS.cAa under the control of Scer\GAL4en-e16E results in wing hairs pointing from the posterior to the anterior compartment in the wing.
Expression of fzScer\UAS.cAa under the control of Scer\GAL4hs.2sev results in planar cell polarity defects in the eye, including a high number of symmetrical ommatidia containing two R3 cells.
Expression of fzScer\UAS.cAa under the control of Scer\GAL4ptc-559.1 results in wing hairs pointing away from the midline within the expression domain. Outside of the expression domain wing hair polarity is normal.
Expression of fzScer\UAS.cAa in the border cells under the control of Scer\GAL4slbo.2.6 delays border cell migration. A reduction in the number of large actin-protrusions from the border cell cluster compared to wild-type clusters is observed.
Expression of fzScer\UAS.cAa under the control of Scer\GAL4hs.2sev results in planar polarity defects in the eye; misrotated ommatidia and symmetrical nonchiral ommatidia are seen (only 44.9% of ommatidia are correctly rotated).
The planar polarity defects seen in the eyes of animals expressing fzScer\UAS.cAa under the control of Scer\GAL4hs.2sev are almost completely suppressed by fz30 (76.0% of ommatidia are correctly rotated).
Only 30.3% of ommatidia are correctly rotated in flies expressing fzScer\UAS.cAa under the control of Scer\GAL4hs.2sev and also co-expressing fzarm.T:Avic\GFP-EGFP.
The ommatidia of fzScer\UAS.cAa; Scer\GAL4sev.PM181 adult eyes have random chirality and some are symmetrical, with two R3 photoreceptors in place of an R3/R4 pair.
Expression of fzScer\UAS.cAa under the control of Scer\GAL4dpp.blk1 in a stripe along the proximo-distal axis of the wing results in a reorientation of wing hairs, which now point laterally away from the expression domain.
When expression is driven by Scer\GAL4Dll-md23, such that fz expression decreases away from the distal part of the wing, the wing hairs point proximally, instead of distally.
When fzScer\UAS.cAa is driven by Scer\GAL4ptc-559.1 in a stripe along the proximal distal axis of the wing, a reorganized polarity results in those cells, that is perpendicular to the normal axis. The wing hairs in the region between wing vein L3 and L4, distal to the anterior crossvein point away from the midline of the wing, unlike wild-type wings, where the wing hairs point distally.
When expression is driven by Scer\GAL4hs.2sev, ommatidia are often mis-rotated and show chirality defects. Most of the symmetrical clusters are R3/R3 symmetrical.
fzScer\UAS.cAa driven by Scer\GAL4ap-md52 disrupts the planar polarity of bristles in the notum, primarily affecting microchaetae. Induction of ectopic scutellar bristles are also seen about 80% of the time. In the pupal notum of flies expressing fzScer\UAS.cAa driven by Scer\GAL4ap-md52, the spindle orientations of the Sensory organ precursors (SOP) become randomized.
When expressed in the wing under the control of Scer\GAL4ptc-559.1, wing hairs are orientated away from the highest point of the fz gradient.
Scer\GAL4Dll-md23-mediated expression causes a region of reversed polarity near the distal end of the wing. Scer\GAL4ptc-559.1-mediated expression causes a region of reverse polarity in anterior compartment cells along the anterior-posterior compartment border.
Causes a tissue polarity defect when expressed in a subset of photoreceptors in the developing eye using Scer\GAL4hs.2sev; ommatidia frequently show abnormal rotation and chirality.