FlyBase Allele Report: Dmel\in[1]

General Information

Symbol

Dmel\in¹

Species

D. melanogaster

Name

FlyBase ID

FBal0005591

Feature type

allele

Associated gene

Dmel\in

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Adler et al., 1994)

Mutagen

spontaneous

(Adler et al., 1994)

Progenitor genotype

Cytology

Polytene chromosomes normal.

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity

(Lee and Adler, 2002)

visible | cold sensitive

(Adler et al., 1994)

Phenotype Manifest In

bract

(Lee and Adler, 2002)

macrochaeta & adult thorax

(Lee and Adler, 2002)

macrochaeta | cold sensitive

(Adler et al., 1994)

microchaeta & adult thorax

(Lee and Adler, 2002)

microchaeta & leg

(Lee and Adler, 2002)

microchaeta & wing

(Park et al., 1996)

wing | pupal stage

(Pataki et al., 2010)

wing cell

(Wong and Adler, 1993)

wing hair

(Wong and Adler, 1993)

wing hair & 1st posterior cell

(Lee and Adler, 2002)

Detailed Description

Statement

Reference

Some of the in¹ mutant pupal wing cells fail to adopt a hexagonal shape.

(Pataki et al., 2010)

Mutants show no significant disruption of ovarian morphology.

(Cohen et al., 2002)

Hairs point slightly posteriorly in the C region of the wing. The hairs on the scutellum point anteriorly, and thorax microchaetae are routinely split. In the adult thorax some bristles are split. On the leg, hair polarity is abnormal, and more multiple leg hairs are found than in fz¹ mutants. Mispositioned bracts are not a feature of the phenotype, though bracts may be multiplied. Joint duplications are rare.

(Lee and Adler, 2002)

Unmarked clones in all regions of the wing display an in phenotype, cells form more than one hair and hairs with an abnormal polarity. Marked clones in the wing indicate in acts autonomously, cells bordering clones are wild type.

(Park et al., 1996)

Viable as a homozygote or a hemizygote. Strong thoracic bristle and wing hair phenotype. Percentage of dorsal wing surface cells that display abnormal cell polarity and the percentage of wing cells forming more than one hair is more severe at 18^oC than 29^oC.

(Adler et al., 1994)

Many wing cells of homozygous flies form two or three hairs. Homozygous flies have disruptions in the pattern of wing hair polarity. The prehair initiation site is along the cell periphery, but not restricted to the distal vertex in pupal wing cells. Double mutants of in¹ with fz^unspecified, dsh¹ or pk¹ resemble in¹ single mutants. Double mutants of in¹ with mwh¹ resemble mwh¹ single mutants.

(Wong and Adler, 1993)

Hairs and bristles on thorax and abdominal tergites, directed irregularly toward midline; trichomes and chaetae on mesonotum coordinately misdirected (Toney and Thompson, 1980). Marginal hairs of wing stand out from wing margin; trichomes on wing blade no longer directed in parallel with longitudinal veins; frequently divergent therefrom. 50-60% of trichome-bearing cells express duplicated or rarely triplicated trichomes. Wings slightly spread and tend to be long and narrow. Somatic clones of homozygous cells in wing described by Gubb and Garcia-Bellido. Incomplete extra leg joints tend to form as mirror-image duplications proximal to the normal joints on tarsal segments three and four (Held, Duarte and Derakhshanian, 1986). RK1.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

in¹ has visible | adult stage phenotype, non-enhanceable by fz¹/fz¹

(Wang et al., 2017)

in¹ has abnormal planar polarity | adult stage phenotype, non-enhanceable by fz¹/fz¹

(Wang et al., 2017)

in¹ has abnormal planar polarity | somatic clone phenotype, non-enhanceable by grh^IM

(Lee and Adler, 2004)

Suppressed by

Statement

Reference

in¹ has abnormal planar polarity phenotype, suppressible by fz^UAS.cAa/Scer\GAL4^Dll-md23

(Lee and Adler, 2002)

NOT suppressed by

Statement

Reference

in¹ has abnormal planar polarity | somatic clone phenotype, non-suppressible by grh^IM

(Lee and Adler, 2004)

Enhancer of

Statement

Reference

in¹/in[+] is an enhancer of visible phenotype of Rab23⁵¹/Rab23^T69A

(Pataki et al., 2010)

NOT Enhancer of

Statement

Reference

in¹ is a non-enhancer of abnormal planar polarity | somatic clone phenotype of grh^IM

(Lee and Adler, 2004)

Suppressor of

Statement

Reference

in¹ is a suppressor of abnormal planar polarity phenotype of Scer\GAL4^Dll-md23, stan^UAS.cUa

(Lee and Adler, 2002)

NOT Suppressor of

Statement

Reference

in¹ is a non-suppressor of abnormal planar polarity | somatic clone phenotype of grh^IM

(Lee and Adler, 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

in¹ has wing hair & 1st posterior cell phenotype, enhanceable by mwh[+]/mwh¹

(Lee and Adler, 2002)

in¹ has wing hair | somatic clone phenotype, enhanceable by ultA¹

(Adler et al., 2000)

NOT Enhanced by

Statement

Reference

in¹ has abdominal sternite bristle phenotype, non-enhanceable by fz¹/fz¹

(Wang et al., 2017)

in¹ has wing hair | somatic clone phenotype, non-enhanceable by grh^IM

(Lee and Adler, 2004)

in¹ has wing hair | increased number | somatic clone phenotype, non-enhanceable by grh^IM

(Lee and Adler, 2004)

Suppressed by

Statement

Reference

in¹ has wing hair & 1st posterior cell phenotype, suppressible by fz^UAS.cAa/Scer\GAL4^Dll-md23

(Lee and Adler, 2002)

in¹ has wing hair & 1st posterior cell phenotype, suppressible by Scer\GAL4^ptc-559.1/pk^UAS.cGa

(Lee and Adler, 2002)

NOT suppressed by

Statement

Reference

in¹ has wing hair | somatic clone phenotype, non-suppressible by grh^IM

(Lee and Adler, 2004)

in¹ has wing hair | increased number | somatic clone phenotype, non-suppressible by grh^IM

(Lee and Adler, 2004)

in¹ has microchaeta & adult thorax phenotype, non-suppressible by fz¹

(Lee and Adler, 2002)

in¹ has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Enhancer of

Statement

Reference

in¹/in[+] is an enhancer of wing hair | increased number phenotype of Scer\GAL4^en.PU, cmb^{UAS.RA.Tag:FLAG}

(Fagan et al., 2014)

in¹/in[+] is an enhancer of wing hair phenotype of Rab23⁵¹/Rab23^T69A

(Pataki et al., 2010)

in¹ is an enhancer of wing hair phenotype of sha^VB13

(Ren et al., 2006)

in¹ is an enhancer of wing hair | somatic clone phenotype of ultA¹

(Adler et al., 2000)

NOT Enhancer of

Statement

Reference

in¹ is a non-enhancer of wing hair | somatic clone phenotype of grh^IM

(Lee and Adler, 2004)

in¹ is a non-enhancer of wing hair | increased number | somatic clone phenotype of grh^IM

(Lee and Adler, 2004)

in¹ is a non-enhancer of tarsal segment phenotype of fz¹

(Lee and Adler, 2002)

in¹ is a non-enhancer of bract phenotype of fz¹

(Lee and Adler, 2002)

in¹ is a non-enhancer of leg joint phenotype of fz¹

(Lee and Adler, 2002)

Suppressor of

Statement

Reference

in¹ is a suppressor of wing hair phenotype of Scer\GAL4^Dll-md23, stan^UAS.cUa

(Lee and Adler, 2002)

in¹ is a suppressor of wing disc | P-stage phenotype of fz¹

(Lee and Adler, 2002)

NOT Suppressor of

Statement

Reference

in¹ is a non-suppressor of wing hair | somatic clone phenotype of grh^IM

(Lee and Adler, 2004)

in¹ is a non-suppressor of wing hair | increased number | somatic clone phenotype of grh^IM

(Lee and Adler, 2004)

in¹ is a non-suppressor of bract phenotype of fz¹

(Lee and Adler, 2002)

in¹ is a non-suppressor of eye phenotype of fz¹

(Lee and Adler, 2002)

in¹ is a non-suppressor of leg joint phenotype of fz¹

(Lee and Adler, 2002)

in¹ is a non-suppressor of ommatidium phenotype of fz¹

(Lee and Adler, 2002)

in¹ is a non-suppressor of tarsal segment phenotype of fz¹

(Lee and Adler, 2002)

in¹ is a non-suppressor of microchaeta & adult thorax | somatic clone | cell non-autonomous phenotype of fz¹

(Lee and Adler, 2002)

in¹/in^II53 is a non-suppressor of wing hair | heat sensitive phenotype of fz^hs.PP

(Lee and Adler, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

in¹,fz¹ double mutant adults display hair polarity defects in abdominal bristles that are similarly severe as in in single mutants.

(Wang et al., 2017)

Heterozygosity significantly enhances the multiple hair cell phenotype of Scer\GAL4^en.PU cmb^Scer\UAS.RA wings.

(Fagan et al., 2014)

in¹ dominantly enhances the number of multiple hairs in certain regions of :Rab23⁵¹/Rab23^T69A mutant wings.

(Pataki et al., 2010)

When grh^IM mutant clones are made in an in¹ mutant wing the grh^IM phenotype is still seen.

(Lee and Adler, 2004)

Late gain of function phenotype of fz^hs.PP is not suppressible by in^II53/in¹ or fy⁶. Leg phenotypes of fz¹ and fy¹ or in¹ are additive.

(Lee and Adler, 2002)

In somatic clones of cells that are homozygous for both in¹ and ultA¹, an increase is seen in the average number of wing hairs per cell.

(Adler et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

in^G5

(Lukinova et al., 1999)

in^R3

(Lukinova et al., 1999)

in^X2

(Lukinova et al., 1999)

Comments

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (53)

Bloomington

607

st¹ in¹ kni^ri-1 p^p

2406

st¹ in¹ kni^ri-1 Scm^D1/TM3, Sb¹

620

Diap1^th-1 st¹ cp¹ in¹ kni^ri-1 p^p

7052

st¹ in¹ kni^ri-1 p^p wts^3-17/TM3, Sb¹

7054

st¹ in¹ kni^ri-1 p^p l(3)99DEd^6-8/TM3, Sb¹

7057

st¹ in¹ kni^ri-1 p^p l(3)99DEe^6-4/TM3, Sb¹

Kyoto

101651

in¹

105927

cp¹ in¹ kni^ri-1 p^p

107313

st¹ in¹ kni^ri-1 Scm^D1/TM3, Sb¹

105945

fz¹ st¹ cp¹ in¹ kni^ri-1 p^p/TM1

106012

Diap1^th-1 st¹ cp¹ in¹ kni^ri-1 p^p

106192

st¹ hid¹ Crown¹ in¹ kni^ri-1/TM3, Sb¹

More stocks available...

Notes on Origin

Discoverer

Bridges, 20th Feb. 1926.

Comments

Strong in allele.

(Adler et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

in¹

(Wang et al., 2017, Fagan et al., 2014, Pataki et al., 2010, Christensen et al., 2008.12.28, Ren et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (19)

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