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General Information
Symbol
Dmel\in1
Species
D. melanogaster
Name
FlyBase ID
FBal0005591
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference
Carried on aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Some of the in1 mutant pupal wing cells fail to adopt a hexagonal shape.

Mutants show no significant disruption of ovarian morphology.

Hairs point slightly posteriorly in the C region of the wing. The hairs on the scutellum point anteriorly, and thorax microchaetae are routinely split. In the adult thorax some bristles are split. On the leg, hair polarity is abnormal, and more multiple leg hairs are found than in fz1 mutants. Mispositioned bracts are not a feature of the phenotype, though bracts may be multiplied. Joint duplications are rare.

Unmarked clones in all regions of the wing display an in phenotype, cells form more than one hair and hairs with an abnormal polarity. Marked clones in the wing indicate in acts autonomously, cells bordering clones are wild type.

Viable as a homozygote or a hemizygote. Strong thoracic bristle and wing hair phenotype. Percentage of dorsal wing surface cells that display abnormal cell polarity and the percentage of wing cells forming more than one hair is more severe at 18oC than 29oC.

Many wing cells of homozygous flies form two or three hairs. Homozygous flies have disruptions in the pattern of wing hair polarity. The prehair initiation site is along the cell periphery, but not restricted to the distal vertex in pupal wing cells. Double mutants of in1 with fzunspecified, dsh1 or pk1 resemble in1 single mutants. Double mutants of in1 with mwh1 resemble mwh1 single mutants.

Hairs and bristles on thorax and abdominal tergites, directed irregularly toward midline; trichomes and chaetae on mesonotum coordinately misdirected (Toney and Thompson, 1980). Marginal hairs of wing stand out from wing margin; trichomes on wing blade no longer directed in parallel with longitudinal veins; frequently divergent therefrom. 50-60% of trichome-bearing cells express duplicated or rarely triplicated trichomes. Wings slightly spread and tend to be long and narrow. Somatic clones of homozygous cells in wing described by Gubb and Garcia-Bellido. Incomplete extra leg joints tend to form as mirror-image duplications proximal to the normal joints on tarsal segments three and four (Held, Duarte and Derakhshanian, 1986). RK1.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement
Reference

in1 has visible | adult stage phenotype, non-enhanceable by fz1/fz1

in1 has abnormal planar polarity | adult stage phenotype, non-enhanceable by fz1/fz1

Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Enhancer of
Statement
Reference

in1/in[+] is an enhancer of visible phenotype of Rab2351/Rab23T69A

NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference

in1 is a non-suppressor of abnormal planar polarity | somatic clone phenotype of grhIM

Phenotype Manifest In
Enhanced by
Statement
Reference

in1 has wing hair & 1st posterior cell phenotype, enhanceable by mwh[+]/mwh1

in1 has wing hair | somatic clone phenotype, enhanceable by ultA1

NOT Enhanced by
Statement
Reference

in1 has abdominal sternite bristle phenotype, non-enhanceable by fz1/fz1

in1 has wing hair | somatic clone phenotype, non-enhanceable by grhIM

in1 has wing hair | increased number | somatic clone phenotype, non-enhanceable by grhIM

Suppressed by
Statement
Reference

in1 has wing hair & 1st posterior cell phenotype, suppressible by fzUAS.cAa/Scer\GAL4Dll-md23

in1 has wing hair & 1st posterior cell phenotype, suppressible by Scer\GAL4ptc-559.1/pkUAS.cGa

NOT suppressed by
Statement
Reference

in1 has wing hair | somatic clone phenotype, non-suppressible by grhIM

in1 has wing hair | increased number | somatic clone phenotype, non-suppressible by grhIM

in1 has microchaeta & adult thorax phenotype, non-suppressible by fz1

in1 has phenotype, non-suppressible by su(Hw)2

Enhancer of
Statement
Reference

in1/in[+] is an enhancer of wing hair phenotype of Rab2351/Rab23T69A

in1 is an enhancer of wing hair phenotype of shaVB13

in1 is an enhancer of wing hair | somatic clone phenotype of ultA1

NOT Enhancer of
Statement
Reference

in1 is a non-enhancer of wing hair | somatic clone phenotype of grhIM

in1 is a non-enhancer of wing hair | increased number | somatic clone phenotype of grhIM

in1 is a non-enhancer of tarsal segment phenotype of fz1

in1 is a non-enhancer of bract phenotype of fz1

in1 is a non-enhancer of leg joint phenotype of fz1

Suppressor of
Statement
Reference

in1 is a suppressor of wing disc | P-stage phenotype of fz1

NOT Suppressor of
Statement
Reference

in1 is a non-suppressor of wing hair | somatic clone phenotype of grhIM

in1 is a non-suppressor of wing hair | increased number | somatic clone phenotype of grhIM

in1 is a non-suppressor of ommatidium phenotype of fz1

in1 is a non-suppressor of tarsal segment phenotype of fz1

in1 is a non-suppressor of microchaeta & adult thorax | somatic clone | cell non-autonomous phenotype of fz1

in1/inII53 is a non-suppressor of wing hair | heat sensitive phenotype of fzhs.PP

in1 is a non-suppressor of bract phenotype of fz1

in1 is a non-suppressor of eye phenotype of fz1

in1 is a non-suppressor of leg joint phenotype of fz1

Additional Comments
Genetic Interactions
Statement
Reference

in1,fz1 double mutant adults display hair polarity defects in abdominal bristles that are similarly severe as in in single mutants.

Heterozygosity significantly enhances the multiple hair cell phenotype of Scer\GAL4en.PU cmbScer\UAS.RA wings.

in1 dominantly enhances the number of multiple hairs in certain regions of :Rab2351/Rab23T69A mutant wings.

When grhIM mutant clones are made in an in1 mutant wing the grhIM phenotype is still seen.

Late gain of function phenotype of fzhs.PP is not suppressible by inII53/in1 or fy6. Leg phenotypes of fz1 and fy1 or in1 are additive.

In somatic clones of cells that are homozygous for both in1 and ultA1, an increase is seen in the average number of wing hairs per cell.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (1)
Stocks (58)
Notes on Origin
Discoverer

Bridges, 20th Feb. 1926.

Comments
Comments

Strong in allele.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (19)