FlyBase Allele Report: Dmel\Rab23[51]

General Information

Symbol

Dmel\Rab23⁵¹

Species

D. melanogaster

Name

FlyBase ID

FBal0246044

Feature type

allele

Associated gene

Dmel\Rab23

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Pataki et al., 2010)

Mutagen

P-element activity

(Pataki et al., 2010)

Progenitor genotype

P{RS5}Rab23^5-SZ-3123

(Pataki et al., 2010)

Cytology

Description

Imprecise excision of P{RS5}Rab23^5-SZ-3123 that leaves behind a 1.7 kb fragment of the progenitor P{RS5}Rab23^5-SZ-3123-element and results in a small deletion that removes the second exon (including the ATG start codon).

(Pataki et al., 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:5,682,464..5,684,579 [-]

Comment:

Approximate endpoints of a deletion resulting from the imprecise excision of P{RS5}Rab23^5-SZ-3123. The first breakpoint is within the insertion (443 bp from the 5' end of the insertion remain) and the second breakpoint is in the second intron (position estimated from map).

(Pataki et al., 2010)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity (with Df(3R)BSC47)

(Pataki et al., 2010)

abnormal planar polarity | recessive

(Pataki et al., 2010)

viable

(Pataki et al., 2010)

viable (with Df(3R)BSC47)

(Pataki et al., 2010)

viable (with Rab23^T69A)

(Pataki et al., 2010)

visible (with Df(3R)BSC47)

(Pataki et al., 2010)

visible (with Rab23^T69A)

(Pataki et al., 2010)

visible | recessive

(Pataki et al., 2010)

Phenotype Manifest In

abdominal sternite

(Pataki et al., 2010)

abdominal tergite

(Pataki et al., 2010)

leg

(Pataki et al., 2010)

microchaeta

(Pataki et al., 2010)

wing hair

(Pataki et al., 2010)

wing hair (with Df(3R)BSC47)

(Pataki et al., 2010)

wing hair (with Rab23^T69A)

(Pataki et al., 2010)

Detailed Description

Statement

Reference

Rab23⁵¹ is homozygous viable. Homozygous Rab23⁵¹ and hemizygous Rab23⁵¹/Df(3R)BSC47 mutants display wing hair phenotypes including multiple hairs and hair orientation defects.

Ommatidial polarity and the orientation of the epidermal bristles on the notum, legs, and abdomen are unaffected in Rab23⁵¹ mutants. Conversely, the trichomes covering the legs and abdomen show abnormal orientation and number in Rab23⁵¹ mutants. The orientation defects are equally evident on the legs, tergites, sternites and pleural regions of the abdominal cuticle. In Rab23⁵¹ mutants, hair polarity appears randomised all over the tergites and the formation of multiple hairs is obvious on the leg and abdominal cuticle.

Rab23⁵¹/Rab23^T69A mutants exhibit a multiple wing hair phenotype.

(Pataki et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Rab23⁵¹/Rab23^T69A has visible phenotype, enhanceable by in¹/in[+]

(Pataki et al., 2010)

Rab23⁵¹ has visible | recessive phenotype, enhanceable by fy[+]/fy³

(Pataki et al., 2010)

Rab23⁵¹ has abnormal planar polarity | recessive phenotype, enhanceable by fz²¹

(Pataki et al., 2010)

Rab23⁵¹ has visible | recessive phenotype, enhanceable by frtz[+]/frtz¹

(Pataki et al., 2010)

Rab23⁵¹ has visible | recessive phenotype, enhanceable by Vang^stbm-6

(Pataki et al., 2010)

Rab23⁵¹ has abnormal planar polarity | recessive phenotype, enhanceable by Vang^stbm-6

(Pataki et al., 2010)

Rab23⁵¹ has visible | recessive phenotype, enhanceable by mwh[+]/mwh¹

(Pataki et al., 2010)

NOT Enhanced by

Statement

Reference

Rab23⁵¹ has visible | recessive phenotype, non-enhanceable by rok[+]/Rok²

(Pataki et al., 2010)

Rab23⁵¹ has visible | recessive phenotype, non-enhanceable by Rho1^72F/Rho1[+]

(Pataki et al., 2010)

NOT suppressed by

Statement

Reference

Rab23⁵¹ has visible | recessive phenotype, non-suppressible by rok[+]/Rok²

(Pataki et al., 2010)

Rab23⁵¹ has visible | recessive phenotype, non-suppressible by Rho1^72F/Rho1[+]

(Pataki et al., 2010)

Enhancer of

Statement

Reference

Rab23⁵¹ is an enhancer of visible | recessive phenotype of fz²¹

(Pataki et al., 2010)

Rab23[+]/Rab23⁵¹ is an enhancer of visible | recessive phenotype of pk³⁰

(Pataki et al., 2010)

Rab23[+]/Rab23⁵¹ is an enhancer of visible | recessive phenotype of fz²¹

(Pataki et al., 2010)

Rab23[+]/Rab23⁵¹ is an enhancer of visible | heat sensitive phenotype of fz^hs.PP

(Pataki et al., 2010)

NOT Enhancer of

Statement

Reference

Rab23⁵¹ is a non-enhancer of visible | recessive phenotype of frtz¹

(Pataki et al., 2010)

Rab23⁵¹ is a non-enhancer of abnormal planar polarity | recessive phenotype of frtz¹

(Pataki et al., 2010)

Rab23⁵¹ is a non-enhancer of visible | recessive phenotype of mwh¹

(Pataki et al., 2010)

Suppressor of

Statement

Reference

Rab23⁵¹ is a suppressor of abnormal planar polarity | recessive phenotype of pk³⁰

(Pataki et al., 2010)

NOT Suppressor of

Statement

Reference

Rab23⁵¹ is a non-suppressor of visible | recessive phenotype of frtz¹

(Pataki et al., 2010)

Rab23⁵¹ is a non-suppressor of abnormal planar polarity | recessive phenotype of frtz¹

(Pataki et al., 2010)

Rab23⁵¹ is a non-suppressor of visible | recessive phenotype of mwh¹

(Pataki et al., 2010)

Other

Statement

Reference

Rab23⁵¹, pk³⁰ has visible | recessive phenotype

(Pataki et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

Rab23⁵¹/Rab23^T69A has wing hair phenotype, enhanceable by in¹/in[+]

(Pataki et al., 2010)

Rab23⁵¹ has wing hair phenotype, enhanceable by frtz[+]/frtz¹

(Pataki et al., 2010)

Rab23⁵¹ has wing hair phenotype, enhanceable by Vang^stbm-6

(Pataki et al., 2010)

Rab23⁵¹ has wing hair phenotype, enhanceable by mwh[+]/mwh¹

(Pataki et al., 2010)

Rab23⁵¹ has wing hair phenotype, enhanceable by fy[+]/fy³

(Pataki et al., 2010)

NOT Enhanced by

Statement

Reference

Rab23⁵¹ has wing hair phenotype, non-enhanceable by rok[+]/Rok²

(Pataki et al., 2010)

Rab23⁵¹ has wing hair phenotype, non-enhanceable by Rho1^72F/Rho1[+]

(Pataki et al., 2010)

NOT suppressed by

Statement

Reference

Rab23⁵¹ has wing hair phenotype, non-suppressible by rok[+]/Rok²

(Pataki et al., 2010)

Rab23⁵¹ has wing hair phenotype, non-suppressible by Rho1^72F/Rho1[+]

(Pataki et al., 2010)

Enhancer of

Statement

Reference

Rab23⁵¹ is an enhancer of wing hair phenotype of fz²¹

(Pataki et al., 2010)

Rab23[+]/Rab23⁵¹ is an enhancer of wing hair phenotype of pk³⁰

(Pataki et al., 2010)

Rab23[+]/Rab23⁵¹ is an enhancer of wing hair phenotype of fz²¹

(Pataki et al., 2010)

Rab23[+]/Rab23⁵¹ is an enhancer of wing hair | heat sensitive phenotype of fz^hs.PP

(Pataki et al., 2010)

NOT Enhancer of

Statement

Reference

Rab23⁵¹ is a non-enhancer of wing hair phenotype of frtz¹

(Pataki et al., 2010)

Rab23⁵¹ is a non-enhancer of wing hair phenotype of mwh¹

(Pataki et al., 2010)

NOT Suppressor of

Statement

Reference

Rab23⁵¹ is a non-suppressor of wing hair phenotype of frtz¹

(Pataki et al., 2010)

Rab23⁵¹ is a non-suppressor of wing hair phenotype of mwh¹

(Pataki et al., 2010)

Other

Statement

Reference

Rab23⁵¹, pk³⁰ has wing hair phenotype

(Pataki et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygous Rab23⁵¹ significantly increases the number of multiple wing hairs in fz²¹ mutants.

The double mutant combination fz²¹, Rab23⁵¹ displays a very high number of multiple wing hairs and strong hair orientation defects.

Heterozygous Rab23⁵¹ significantly increases the number of multiple wing hairs in pk³⁰ mutants.

The double mutant combination pk³⁰, Rab23⁵¹ displays a very high number of multiple wing hairs and strong hair orientation defects. The orientation defects in pk³⁰, Rab23⁵¹ double mutants seem weaker than in pk³⁰ single mutants.

Rab23⁵¹ mutant wings that are also heterozygous for frtz¹ display a higher number of multiple hairs than Rab23⁵¹ homozygous wings.

frtz¹, Rab23⁵¹ double mutant wings display a similar number of multiple hairs and strong orientation defects as do frtz¹ single mutants.

The double mutant combination Vang^stbm-6, Rab23⁵¹ displays a very high number of multiple wing hairs and strong hair orientation defects.

The mwh¹ single mutant wing hair phenotype is essentially identical to the mwh¹ , Rab23⁵¹ double mutant phenotype.

mwh¹ dominantly enhances the multiple wing hair phenotype of Rab23⁵¹ mutants.

fy³ dominantly enhances the multiple wing hair phenotype of Rab23⁵¹ mutants.

rok² does not exhibit dominant genetic interaction with Rab23⁵¹.

Rho1^72F does not exhibit dominant genetic interaction with Rab23⁵¹.

Rab23⁵¹ dominantly enhances the multiple hair phenotype induced by late fz^hs.PP overexpression.

(Pataki et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Rab23⁵¹ is rescued by Rab23^+t12.3

(Pataki et al., 2010)

Comments

A single copy of Rab23^+t12.3 rescues the wing hair phenotypes of both Rab23^T69A and Rab23⁵¹.

(Pataki et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Rab23⁵¹

(Pataki et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (1)

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