FlyBase Allele Report: Dmel\fy[3]

General Information

Symbol

Dmel\fy³

Species

D. melanogaster

Name

FlyBase ID

FBal0082919

Feature type

allele

Associated gene

Dmel\fy

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Collier and Gubb, 1997)

Mutagen

X ray

(Collier and Gubb, 1997)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Collier and Gubb, 1997)

Description

70bp deletion, resulting in the C-terminal 210 amino acids being replaced by two amino acid residues (Pro and Ile).

(Collier and Gubb, 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2L:8,402,336..8,402,405 [-]

Comment:

deletion

(Collier and Gubb, 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}

(Chen et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Collier and Gubb, 1997)

visible | recessive

(Collier and Gubb, 1997)

Phenotype Manifest In

wing & trichome

(Collier and Gubb, 1997)

Detailed Description

Statement

Reference

Hemizygous flies show an altered pattern of hair orientation on the wings. A proportion of wing cells secrete up to four hairs instead of the single hair seen in wild-type flies. This phenotype is not uniform across the wing blade. In general, cell hair number increases with deviation of hair polarity from wild-type, although cells with reversed (distal-to-proximal) polarity usually retain wild-type hair number. The phenotype is significantly stronger at 18^oC than at 29^oC.

(Collier and Gubb, 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

fy[+]/fy³ is an enhancer of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

fy[+]/fy³ is an enhancer of visible | recessive phenotype of Rab23⁵¹

(Pataki et al., 2010)

Phenotype Manifest In

Enhancer of

Statement

Reference

fy[+]/fy³ is an enhancer of wing hair | increased number phenotype of Scer\GAL4^en.PU, cmb^{UAS.RA.Tag:FLAG}

(Fagan et al., 2014)

fy[+]/fy³ is an enhancer of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

fy[+]/fy³ is an enhancer of wing hair phenotype of Rab23⁵¹

(Pataki et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity significantly enhances the multiple hair cell phenotype of Scer\GAL4^en.PU cmb^Scer\UAS.RA wings.

(Fagan et al., 2014)

fy³ dominantly enhances the multiple wing hair phenotype of Rab23⁵¹ mutants.

(Pataki et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8875

fy³ cn¹ bw¹ speck¹/CyO, bw¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

fy³

(Chen et al., 2018, Fagan et al., 2014, Djiane and Mlodzik, 2010, Pataki et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close