FB2025_05 , released December 11, 2025
Gene: Dmel\fy
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General Information
Symbol
Dmel\fy
Species
D. melanogaster
Name
fuzzy
Annotation Symbol
CG13396
Feature Type
protein_coding_gene
FlyBase ID
FBgn0001084
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Summary
fuzzy (fy) encodes a cytoplasmic protein that functions as a downstream member of the fz-stan planar cell polarity pathway that controls hair and bristle polarity in the adult. It interacts directly with the product of in and accumulates on the proximal edge of wing cells. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
29C1-29C1
Sequence location
Recombination map
2-32
RefSeq locus
NT_033779 REGION:8401476..8403280
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in establishment or maintenance of cell polarity
inferred from mutant phenotype
(Collier and Gubb, 1997)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in non-motile cilium assembly
inferred from biological aspect of ancestor with PANTHER:PTN004425437
(GO Reference Genome Project, 2011-)
involved_in vesicle-mediated transport
inferred from electronic annotation with InterPro:IPR043970, InterPro:IPR043971, InterPro:IPR043972
(InterPro Project Members, 2004-)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the fuzzy family. (O16868)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
fuzzy (fy) encodes a cytoplasmic protein that functions as a downstream member of the fz-stan planar cell polarity pathway that controls hair and bristle polarity in the adult. It interacts directly with the product of in and accumulates on the proximal edge of wing cells. [Date last reviewed: 2019-03-07]
Protein Function (UniProtKB)
Plays a role in the organization of cell polarity via a planar cell polarity (PCP) cascade. Involved in the development of the hairs on the wings. Specify the correct orientation of the hair by limiting the site of prehair initiation to the distal vertex of the wing cells. Controls wing cell hair number by maintaining the integrity of the cytoskeletal components that direct hair development.
(UniProt, O16868)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
*fy: fuzzy
Hairs on abdomen and thorax irregular and directed toward midline. Hairs on wing margins erect. Hairs on legs also show abnormal polarities (Held, Duarte, and Derakhshanian, 1986, Wilhelm Roux's Arch. Dev. Biol. 195: 145-57). Resembles fz. Fertility and viability below normal. RK2.
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\fy for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O16868)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
fy-RA
FBtr0079712
NM_058152
1688
416
fy-RB
FBtr0331992
NM_001273321
1547
416
Additional Transcript Data and Comments
Reported size (kB)

1.9 (northern blot)

(Collier and Gubb, 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
fy-PA
FBpp0079317
46.3
416
6.77
O16868
NP_477500
AAF52671
fy-PB
FBpp0304314
46.3
416
6.77
O16868
NP_001260250
AGB92786
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

416 aa isoforms: fy-PA, fy-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

416 (aa)

(Collier and Gubb, 1997)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fy using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.18

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
organism
(Collier and Gubb, 1997)
Additional Descriptive Data

Low levels of fy expression are detected in all developmental stages. High levels are detected in 2 day-old pupae, at the time of prehair initiation. Significant expresssion levels are detected in embryos and adult females. fy transcript is detected in all wing cells of 2 day old pupae.

(Collier and Gubb, 1997)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\fy in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 13 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of fy
Transgenic constructs containing regulatory region of fy
Aberrations (Deficiencies and Duplications) ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\FUZ
14 of 14
Yes
Yes
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Fuz
13 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Fuz
13 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\fuz
11 of 13
Yes
Yes
Xtro\dync1i1
10 of 13
No
Yes
Danio rerio (Zebrafish) (1)
Drer\fuz
14 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP008489
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:fy. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    FUZ; fuzzy planar cell polarity protein
    14 of 14
    610622
       
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      fy
      enhanceable
      frtz
      (Collier et al., 2005)
      fy
      enhanceable
      fz
      (Lee and Adler, 2002)
      in|fy
      suppressible
      fz
      (Wang et al., 2014)
      fy
      enhanceable
      mwh
      (Lee and Adler, 2002)
      fy
      enhanceable
      stan
      (Lee and Adler, 2002)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      cmb
      enhanceable
      fy
      (Fagan et al., 2014)
      frtz
      enhanceable
      fy
      (Collier et al., 2005)
      fz
      suppressible
      fy
      (Lee and Adler, 2002)
      in
      enhanceable
      fy
      (Wang et al., 2017, Wang et al., 2014)
      kermit
      enhanceable
      fy
      (Djiane and Mlodzik, 2010)
      pk
      suppressible
      fy
      (Lee and Adler, 2002)
      Rab23
      enhanceable
      fy
      (Pataki et al., 2010)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2L
      Recombination map
      2-32
      Cytogenetic map
      29C1-29C1
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      29C1-29C1
      Limits computationally determined from genome sequence between P{lacW}l(2)k12914k12914&P{lacW}Akap200k07118a and P{lacW}l(2)k03706k03706&P{lacW}Acerk07704
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      29C-29C
      (Collier, 1997.9.4)
      Experimentally Determined Recombination Data
      Location

      2-32

      (FlyBase, 2016)

      2-27.9

      (Comeron et al., 2012)

      2-24.1

      (Grell, 1969)
      Left of (cM)
      Right of (cM)
      (Grell, 1969)
      Notes
      Stocks and Reagents
      Stocks (16)
      Genomic Clones (19)
      cDNA Clones (3)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              Functions downstream of fz for planar polarity in the wing. in and fy are needed in cells receiving and responding to a fz dependent intercellular signal. Genetic analysis is not consistent with fz-like class of genes fz, pk, Vang, stan and dsh acting simply as positive or negative regulators of in and fy.

              (Lee and Adler, 2002)

              Mutations in fz-like class of genes fz, pk, Vang, stan and dsh act as strong enhancers of weak in or fy phenotypes. Vinblastine enhances the multiple wing hair phenotype of in and fy mutants indicating that the microtubule cytoskeleton has a function independent of the fz pathway. In the wing as in the abdomen in and fy are epistatic to fz as double mutants resemble in and fy and not fz. In the eye fz is epistatic to in and fy. In terms of the wing eversion phenotype of fz, in and fy appear to be epistatic to fz.

              (Lee and Adler, 2002)
              Relationship to Other Genes
              Source for database merge of
              Additional comments
              Nomenclature History
              Source for database identify of
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (6)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 49 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              References (106)