FlyBase Allele Report: Dmel\frtz[1]

General Information

Symbol

Dmel\frtz¹

Species

D. melanogaster

Name

FlyBase ID

FBal0101418

Feature type

allele

Associated gene

Dmel\frtz

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Collier et al., 2005)

Progenitor genotype

Cytology

Description

Amino acid replacement: Y506term.

(Collier et al., 2005)

Nucleotide substitution: T?A.

(Collier et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:1,713,319..1,713,319 [-]

Nucleotide change:

T1713319A

Reported nucleotide change:

T?A

Amino acid change:

Y506term | frtz-PA; Y506term | frtz-PB; Y506term | frtz-PD

Reported amino acid change:

Y506term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Comment:

Difference thought to be responsible for mutant phenotype. Other differences thought to be polymorphic variants.

(Collier et al., 2005)

sequence_variant

2L:1,713,213..1,713,213 [-]

Nucleotide change:

T6649A

Amino acid change:

D542N | frtz-PA; D542N | frtz-PB; D542N | frtz-PD

Reported amino acid change:

D542N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Comment:

One of four amino acid substitutions reported for this allele. Difference thought to be polymorphic variant.

(Collier et al., 2005)

sequence_variant

2L:1,712,621..1,712,621 [-]

Nucleotide change:

C7241A

Amino acid change:

P720T | frtz-PA; P720T | frtz-PB; P720T | frtz-PD

Reported amino acid change:

P720T

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. One of four amino acid substitutions reported for this allele. Difference thought to be polymorphic variant.

(Collier et al., 2005)

sequence_variant

2L:1,712,399..1,712,399 [-]

Nucleotide change:

C7463A

Amino acid change:

P776T | frtz-PA; P776T | frtz-PB; P771T | frtz-PD

Reported amino acid change:

P776T

Comment:

(Collier et al., 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity

(Collier et al., 2005)

abnormal planar polarity | recessive

(Pataki et al., 2010)

visible

(Collier et al., 2005)

visible (with Df(2L)Exel6005)

(Miller et al., 2020)

visible | recessive

(Pataki et al., 2010)

Phenotype Manifest In

chaeta (with Df(2L)Exel6005)

(Miller et al., 2020)

triple row of wing sensilla

(Collier et al., 2005)

wing | pupal stage

(Pataki et al., 2010)

wing hair

(Pataki et al., 2010)

Detailed Description

Statement

Reference

Some of the frtz¹ mutant pupal wing cells fail to adopt a hexagonal shape.

frtz¹ mutant wings display a very high number of multiple hairs and strong orientation defects.

(Pataki et al., 2010)

Strong allele. The bristles of the triple row of the anterior wing margin point more anteriorly than those of wild type and follow the local polarity of cell hairs in homozygotes. Wing cell hairs in mutant adults arise from the apical centre of the cell as they do in wild-type flies.

(Collier et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

frtz¹ has visible | recessive phenotype, non-enhanceable by Rab23⁵¹

(Pataki et al., 2010)

frtz¹ has abnormal planar polarity | recessive phenotype, non-enhanceable by Rab23⁵¹

(Pataki et al., 2010)

NOT suppressed by

Statement

Reference

frtz¹ has visible | recessive phenotype, non-suppressible by Rab23⁵¹

(Pataki et al., 2010)

frtz¹ has abnormal planar polarity | recessive phenotype, non-suppressible by Rab23⁵¹

(Pataki et al., 2010)

Enhancer of

Statement

Reference

frtz[+]/frtz¹ is an enhancer of visible | recessive phenotype of Rab23⁵¹

(Pataki et al., 2010)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

frtz¹ has wing hair phenotype, non-enhanceable by Rab23⁵¹

(Pataki et al., 2010)

NOT suppressed by

Statement

Reference

frtz¹ has wing hair phenotype, non-suppressible by Rab23⁵¹

(Pataki et al., 2010)

Enhancer of

Statement

Reference

frtz[+]/frtz¹ is an enhancer of wing hair phenotype of Rab23⁵¹

(Pataki et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Rab23⁵¹ mutant wings that are also heterozygous for frtz¹ display a higher number of multiple hairs than Rab23⁵¹ homozygous wings.

frtz¹, Rab23⁵¹ double mutant wings display a similar number of multiple hairs and strong orientation defects as do frtz¹ single mutants.

(Pataki et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

5455

108248

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

fritz¹

(Collier et al., 2005)

frtz¹

(Pataki et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (4)

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