In mwh1 testes the number of normal individualization complexes (ICs), abnormal ICs and waste bags is similar to controls.
mwh1 homozygous adults show hair polarity defects in abdominal bristles.
mwh1 or mwh1/mwh6 flies show a 'multiple hair cell' phenotype in the wing.
Homozygous mwh1 mutant display wing hair defects.
Homozygotes have a multiple wing hair phenotype.
Hairs in the proximal-anterior part of the wing point towards the anterior margin and most cells form multiple hairs in mutant adults.
Some of the mwh1 mutant pupal wing cells fail to adopt a hexagonal shape.
mwh1 mutants display wing hair abnormalities.
mwh1 animals have a multiple wing hair phenotype; the mean number of hairs/cell at 25[o]C is 3.62.
mwh1/mwh6 animals have a multiple wing hair phenotype that is temperature sensitive; the mean number of hairs/cell is 1.83 at 21[o]C and 2.52 at 25[o]C.
Homozygotes show a multiple wing hair phenotype.
Prior to and during the appearance of prehair structures in the pupal wing, mutant cells show excess actin bundling across the apical surface of the cell, sometimes in a "starburst" pattern, with actin bundles radiating from the cell centre. Subsequently, prehair structures are seen at cell edges. The excess actin bundles often extend at least 1μm basally into the cytoplasm from the apical surface, particularly once prehair initiation is underway.
Mutants show no significant disruption of ovarian morphology.
Mutant clones in the wing show disruption of polarity, as indicated by wing hairs.
Hairs and denticles are smaller, more numerous and less orderly than those in wild type.
Wing cells of homozygous flies form more than one hair, with an average of almost four hairs per cell. Homozygous flies have disruptions in the pattern of wing hair polarity. The prehair initiation site is along the cell periphery, but not restricted to the distal vertex in pupal wing cells. Double mutants of mwh1 with fz1, dsh1, pk1, in1 or fy2 resemble mwh1 single mutants.
RK1 Hairs on the wings are grouped in numbers of 2-5 in the place of 1.
Affects the trichomes (hairs) of all body regions in the same general way: An increase in the number of elements is correlated with a reduction in length and a disturbance of orientation. Aristae and bracts are included in this pattern; bristles and other sensilla are not. Wing cells contain groups of 2-7 hairs instead of one hair per cell as in wild type; causes supernumerary trichomes over entire integument, but tufts of trichomes only in wing blade (Ouweneel, 1970); may be supernumerary hairs and sensilla on halteres (Ouweneel and van der Meer, 1973). Also causes disruption of polarity in legs, wings and halteres; may disrupt orientation of hairs on leg without affecting their numbers (Bryant and Schneiderman, 1969); trichomes on wings tend to diverge from vein L3 rather than parallel it as in wild type (Gubb and Garcia-Bellido, 1982). mwh/+ develop mwh phenotype following heat shock at or just prior to the time of cell-hair-extrusion (Mitchell and Petersen, 1984). Transplants of mutant wing discs to wild-type hosts develop autonomously (Ursprung and Hadorn, 1962). Widely used as a cell marker in the analysis of cuticular clones. The frequency of mwh spots after somatic recombination in mwh/+ flies increases with increase in the temperature at which the larvae and pupae are raised (Graf, 1986). RK1.