FlyBase Allele Report: Dmel\Rho1[unspecified]

General Information

Symbol

Dmel\Rho1^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0097173

Feature type

allele

Associated gene

Dmel\Rho1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic segment

(Magie et al., 2002)

wing | somatic clone

(Yan et al., 2009)

wing hair | somatic clone | increased number

(Yan et al., 2009)

Detailed Description

Statement

Reference

Homozygous null cells in the wing do not proliferate normally and substantial clones can not be recovered.

Homozygous hypomorphic clones in the wing are typically small. These clones have two mutant phenotypes; some cells appear to be tetraploid (based on cell size) and the cells often form multiple hairs.

(Yan et al., 2009)

25% of homozygous embryos have segmentation defects.

(Magie et al., 2002)

In the sarcomeres of mutant embryo muscles, well defined I bands are seen as seen in wild-type.

(Bloor and Kiehart, 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Rho1^unspecified/Rho1[+] is an enhancer of visible phenotype of mwh⁶/mwh¹

(Yan et al., 2009)

NOT Suppressor of

Statement

Reference

Rho1^unspecified is a non-suppressor of abnormal planar polarity | heat sensitive phenotype of fz^I.hs

(Winter et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

Rho1^unspecified has embryonic segment phenotype, enhanceable by α-Cat^UASp.cMa/Scer\GAL4^Act5C.PI

(Magie et al., 2002)

Rho1^unspecified has embryonic segment phenotype, enhanceable by Scer\GAL4^Act5C.PI/p120ctn^UASp.cMa

(Magie et al., 2002)

NOT Enhanced by

Statement

Reference

Rho1^unspecified has embryonic segment phenotype, non-enhanceable by Scer\GAL4^Act5C.PI/Act5C^UAS.GFP

(Magie et al., 2002)

NOT suppressed by

Statement

Reference

Rho1^unspecified has embryonic segment phenotype, non-suppressible by Scer\GAL4^Act5C.PI/Act5C^UAS.GFP

(Magie et al., 2002)

Rho1^unspecified has embryo | dorsal closure stage phenotype, non-suppressible by Pkn^hs.PL

(Lu and Settleman, 1999)

Enhancer of

Statement

Reference

Rho1^unspecified/Rho1[+] is an enhancer of wing hair | increased number phenotype of mwh⁶/mwh¹

(Yan et al., 2009)

NOT Enhancer of

Statement

Reference

Rho1^unspecified is a non-enhancer of phenotype of Hsap\RALA^G23V.GMR

(Sawamoto et al., 1999)

NOT Suppressor of

Statement

Reference

Rho1^unspecified is a non-suppressor of wing hair phenotype of fz^I.hs

(Winter et al., 2001)

Rho1^unspecified is a non-suppressor of phenotype of Hsap\RALA^G23V.GMR

(Sawamoto et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The mwh¹/mwh⁶ multiple wing hair phenotype is dominantly enhanced by Rho1^unspecified.

(Yan et al., 2009)

The incidence and severity of segmentation defects in homozygous Rho1 mutant embryos is enhanced by expression of p120ctn^{Scer\UAS.P\T.cMa} or α-Cat^{Scer\UAS.P\T.cMa} under the control of Scer\GAL4^Act5C.PI. Expression of Act5C^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^Act5C.PI has no effect on the severity of the Rho1^unspecified mutant phenotype.

(Magie et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Rho1^unspecified

rho

(Fan et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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