FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pknhs.PL
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General Information
Symbol
Dmel\Pknhs.PL
Species
D. melanogaster
Name
heat shock construct of Lu
FlyBase ID
FBal0097187
Feature type
allele
Associated gene
Dmel\Pkn
Associated Insertion(s)
Carried in Construct
P{hs-Pkn.L}
Key Links
Transgenic product class
cDNA
(Lu and Settleman, 1999)
wild_type
(Lu and Settleman, 1999)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Lu and Settleman, 1999)
wild_type
(Lu and Settleman, 1999)
Mutagen
in vitro construct
(Lu and Settleman, 1999)
Progenitor genotype
Carried in construct
P{hs-Pkn.L}
Cytology
Description

The full length Pkn cDNA is expressed under the control of a heat shock promoter.

(Lu and Settleman, 1999)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Pkn
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Pknhs.PL under the control of heat shock does not result in wing defects.

      (Betson and Settleman, 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      Pknhs.PL is a non-suppressor of embryo | dorsal closure stage phenotype of Rho1unspecified

      (Lu and Settleman, 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Pknhs.PL fails to rescue the Rho1unspecified mutant dorsal closure defect.

      (Lu and Settleman, 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Pknhs.PL partially rescues Pkn06736

      (Betson and Settleman, 2007)

      Pknhs.PL partially rescues Pkn06736

      (Lu and Settleman, 1999)
      Comments

      Expression of PknG58A.hs using heat shock can rescue the lethality of Pkn06736 flies.

      (Betson and Settleman, 2007)

      When Pknhs.PL is driven by heat shock (30 min heat shocks, twice a day from 1 to 14 days after egg-laying) in a Pkn06736 background, viability and fertility are rescued, and the number of dorsal-open embryos are significantly reduced.

      (Lu and Settleman, 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Pknhs.PL
      Name Synonyms
      heat shock construct of Lu
      (Lu and Settleman, 1999)
      Secondary FlyBase IDs
        References (2)