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Dickinson, W.J., Thatcher, J.W. (1997). Morphogenesis of denticles and hairs in Drosophila embryos: involvement of actin-associated proteins that also affect adult structures.  Cell Motility Cytoskel. 38(1): 9--21.
FlyBase ID
FBrf0098231
Publication Type
Research paper
Abstract

We sought components that function in morphogenetic events downstream from the segmentation pathway in Drosophila embryos, so we examined mutations that affect development of adult hairs and/or bristles to identify a subset that also affect hairs and denticles on the cuticle of first instar larvae. Mutations at 4 of 23 loci surveyed cause distinct abnormalities in these larval structures, and two other loci have more subtle, variable effects. In particular, forked and singed mutants produce complex, allele-specific phenotypes. These loci encode actin-associated proteins and, consistent with that information, mutations cause abnormalities in actin bundles that support nascent hairs and denticles in stage 14-16 embryos. We suggest that interactions between these and other actin-associated proteins are important in generating the diverse shapes of the cuticular specializations seen in both larvae and adults.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell Motility Cytoskel.
    Title
    Cell Motility and the Cytoskeleton
    Publication Year
    1986-
    ISBN/ISSN
    0886-1544
    Data From Reference
    Aberrations (2)
    Alleles (34)
    Genes (23)