Open Close
General Information
Symbol
Dmel\H1
Species
D. melanogaster
Name
FlyBase ID
FBal0005292
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
H
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of a copia element in the second intron. The insertion occurs in between the T/A at 314/315 base pairs counting from the 5' splice junction.

Insertion whose restriction map matches copia inserted into the 2nd intron.

Insertion components
copia{}H1
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

H1 heterozygous adults display loss of one or more thoracic sensory bristles, as compared o controls.

Homozygous intestinal stem cell clones lose self-renewing capacity over time, and fail to form large clones at 14 days after clone induction, in contrast to wild-type controls.

Mutant embryos show normal boundary cell differentiation in the hindgut.

Heterozygotes show shortening of wing vein L5.

H3/H1 flies have a loss of Sensory Organ Precursors (SOP), and thus in nearly bald pharate adults. Remaining SOPs mainly give rise to quadruple sockets. In H1/HP8 flies a complete transformation of all external sensory organ neurons into sheath cells.

H1/H2 flies produce nota that are bald.

Small L5 gap phenotype at low penetrance in heterozygotes.

Dorsal hairs are sparse compared to wild type. Denticle belts are normal.

Terminal gaps in LIV and LV and occasionally short terminal gaps in LII and LIII.

Strongly enhanced expression of "NAx" alleles.

Mutant flies show shortening of at least one and sometimes more of: wing veins L2, L4 and L5 and the posterior crossvein.

Bristles, especially postverticals and abdominals, missing in heterozygous H1 flies. Bristle sockets present at some sites, not at others. Expressed most distinctly on head; occipital; postvertical and ocellar bristles affected. Veins L4 and L5 do not reach wing margin; occasionally true of L2 also. Recessive lethal. Homozygotes die during larval and pupal stages Animals surviving to pharate adult are completely devoid of macrochaetes and microchaetes on the head and notum, with occasional 'double sockets' remaining on the abdominal tergites. Bristles on the legs significantly resistant to loss of H+ function.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

H1 has visible | dominant phenotype, enhanceable by nmoadk2/nmoadk1

H1 has visible | dominant phenotype, enhanceable by nmoadk1/nmoadk1

Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference

H1 is a non-enhancer of visible phenotype of upd1GMR.PB

Suppressor of
Statement
Reference

H[+]/H1 is a suppressor of visible phenotype of Caf1-105NIG.12892R, Scer\GAL4ey.PH

H[+]/H1 is a suppressor of visible phenotype of Caf1-105NIG.12892R, Scer\GAL4sd.PU

H1 is a suppressor of lethal phenotype of Nnd-p, e(r)p2

H[+]/H1 is a suppressor of visible phenotype of Scer\GAL4en-e16E, pzgdsRNA.UAS

H1 is a suppressor of visible | recessive phenotype of nmoadk2

H1 is a suppressor of visible phenotype of Scer\GAL4bbg-C96, mamN.UAS

H1 is a suppressor | partially of lethal phenotype of Dl1, RpS3[+]/RpS31

H1 is a suppressor | partially of lethal phenotype of Dl[+]/Dl1, RpS31

NOT Suppressor of
Statement
Reference

H1 is a non-suppressor of visible phenotype of upd1GMR.PB

Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

H1 has head bristle phenotype, enhanceable by nmoadk2/nmoadk1

H1 has mesothoracic tergum & macrochaeta phenotype, enhanceable by nmoadk2/nmoadk1

H1 has head bristle phenotype, enhanceable by nmoadk1/nmoadk1

H1 has mesothoracic tergum & macrochaeta phenotype, enhanceable by nmoadk1/nmoadk1

H1 has wing vein L5 phenotype, enhanceable by Su(dx)sp

H1 has macrochaeta phenotype, enhanceable by Su(dx)sp

H1 has microchaeta phenotype, enhanceable by Su(dx)sp

H1 has phenotype, enhanceable by Su(H)eBC11

H1 has phenotype, enhanceable by Su(H)O5

H1 has phenotype, enhanceable by Su(H)T4

H1 has phenotype, enhanceable by Su(H)E(H)

Suppressed by
Statement
Reference

H1 has phenotype, suppressible by Su(H)sA21

H1 has phenotype, suppressible by Su(H)sK2

H1 has phenotype, suppressible by Su(H)sO10

H1 has phenotype, suppressible by Su(H)12

H1 has phenotype, suppressible by Su(H)13

H1 has phenotype, suppressible by Su(H)14

H1 has phenotype, suppressible by Su(H)6

H1 has phenotype, suppressible by Su(H)8

H1 has phenotype, suppressible by Su(H)AM1

H1 has phenotype, suppressible by Su(H)IB115

H1 has phenotype, suppressible by Su(H)11

NOT suppressed by
Statement
Reference

H1 has phenotype, non-suppressible by su(Hw)2

Enhancer of
Statement
Reference

H1 is an enhancer of presutural bristle & trichogen cell phenotype of DlUAS.cJa, Scer\GAL4l(3)31-1-31-1

H1 is an enhancer of posterior scutellar bristle & trichogen cell phenotype of DlUAS.cJa, Scer\GAL4l(3)31-1-31-1

H1 is an enhancer of anterior notopleural bristle & trichogen cell phenotype of DlUAS.cJa, Scer\GAL4l(3)31-1-31-1

H1 is an enhancer of posterior notopleural bristle & trichogen cell phenotype of DlUAS.cJa, Scer\GAL4l(3)31-1-31-1

H1 is an enhancer of anterior supraalar bristle & trichogen cell phenotype of DlUAS.cJa, Scer\GAL4l(3)31-1-31-1

H1 is an enhancer of posterior supraalar bristle & trichogen cell phenotype of DlUAS.cJa, Scer\GAL4l(3)31-1-31-1

H1 is an enhancer of posterior postalar bristle & trichogen cell phenotype of DlUAS.cJa, Scer\GAL4l(3)31-1-31-1

H1 is an enhancer of anterior dorsocentral bristle & trichogen cell phenotype of DlUAS.cJa, Scer\GAL4l(3)31-1-31-1

H1 is an enhancer of posterior dorsocentral bristle & trichogen cell phenotype of DlUAS.cJa, Scer\GAL4l(3)31-1-31-1

H1 is an enhancer of anterior scutellar bristle & trichogen cell phenotype of DlUAS.cJa, Scer\GAL4l(3)31-1-31-1

H1 is an enhancer of microchaeta & scutum phenotype of N60g11

H1 is an enhancer of phenotype of Nl1N-B

H1 is an enhancer of microchaeta & scutum phenotype of Nl1N-B

NOT Enhancer of
Statement
Reference

H1 is a non-enhancer of eye phenotype of upd1GMR.PB

Suppressor of
Statement
Reference

H[+]/H1 is a suppressor of eye phenotype of Caf1-105NIG.12892R, Scer\GAL4ey.PH

H[+]/H1 is a suppressor of wing phenotype of Caf1-105NIG.12892R, Scer\GAL4sd.PU

H[+]/H1 is a suppressor of wing phenotype of Scer\GAL4en-e16E, pzgdsRNA.UAS

H1 is a suppressor of chemosensory ventral triple row & microchaeta | ectopic phenotype of ed4.12

H1 is a suppressor of dorsal triple row & microchaeta | ectopic phenotype of ed4.12

H1 is a suppressor of dorsocentral bristle | ectopic phenotype of ed4.12

H1 is a suppressor of scutellar bristle | ectopic phenotype of ed4.12

H1 is a suppressor of wing vein | ectopic phenotype of nmoadk2

H1 is a suppressor of phenotype of DlTM.sev

H1 is a suppressor of microchaeta phenotype of NAx-9/Nl1N-B

H1 is a suppressor of phenotype of Dl1

H1 is a suppressor of phenotype of NX1

NOT Suppressor of
Statement
Reference

H1 is a non-suppressor of eye phenotype of upd1GMR.PB

Other
Additional Comments
Genetic Interactions
Statement
Reference

H1 heterozygous adults also expressing Rbfox1dsRNA.Scer\UAS under the control of Scer\GAL4sca-109-68 exhibit an enhanced loss of thoracic sensory bristles and exhibit a significant amount of sockets instead of bristles, as compared to H1 heterozygotes.

One copy of H1 fully suppresses the small eye phenotype seen when Caf1-105NIG.12892R is expressed under the control of Scer\GAL4ey.PH.

One copy of H1 suppresses the wing phenotypes seen when Caf1-105NIG.12892R is expressed under the control of Scer\GAL4sd.PU. Instead the flies have interruption to longitudinal vein 5 in the distal part.

The reduction in wing area seen in flies expressing pzgdsRNA.Scer\UAS under the control of Scer\GAL4en-e16E is suppressed by NAx-M1/+ or H1/+.

The ectopic wing veins seen in nmoadk2 flies are completely suppressed by H1. The loss of bristles on the head and notum seen in H1/+ flies is dramatically enhanced by nmoadk1/nmoadk1 or nmoadk1/nmoadk2.

The addition of H1 suppresses the wing nicking phenotype seen in mamN.Scer\UAS, Scer\GAL4C96 flies producing a range of phenotypes.

Heterozygous vein L5 gap phenotype is enhanced by hetero- and homozygotes for Su(dx)sp which also enhances the bristle loss phenotype of H1.

Enhances the transformation of the trichogen to a tormogen fate in the notal macrochaetae caused by DlScer\UAS.cJa expressed under the control of Scer\GAL4l(3)31-1-31-1. Widespread transformation of microchaetae is also seen in this background.

Enhances the microchaetae and macrochaetae loss phenotype of N gain of function heterozygotes.

The lethality of Dl1 RpS31 heterozygotes is partially suppressed by H1.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (1)
Stocks (22)
Notes on Origin
Discoverer

Bridges, 4th March 1916.

Comments
Comments

Phenotypic series of H alleles, progressing from strongest (amorphic) to weakest mutant phenotype: HB79 = H81 >> H1 = H99 > Hbob > H94a > H88d > HB8 > H2 >= H3 > HA120.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (47)