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Reference
Citation
Fostier, M., Evans, D.A., Artavanis-Tsakonas, S., Baron, M. (1998). Genetic characterization of the Drosophila melanogaster suppressor of deltex gene: a regulator of Notch signaling.  Genetics 150(4): 1477--1485.
FlyBase ID
FBrf0105825
Publication Type
Research paper
Abstract

The Notch receptor signaling pathway regulates cell differentiation during the development of multicellular organisms. A number of genes are known to be components of the pathway or regulators of the Notch signal. One candidate for a modifier of Notch function is the Drosophila Suppressor of deltex gene [Su(dx)]. We have isolated four new alleles of Su(dx) and mapped the gene between 22B4 and 22C2. Loss-of-function Su(dx) mutations were found to suppress phenotypes resulting from loss-of-function of Notch signaling and to enhance gain-of-function Notch mutations. Hairless, a mutation in a known negative regulator of the Notch pathway, was also enhanced by Su(dx). Phenotypes were identified for Su(dx) in wing vein development, and a role was demonstrated for the gene between 20 and 30 hr after puparium formation. This corresponds to the period when the Notch protein is involved in refining the vein competent territories. Taken together, our data indicate a role for Su(dx) as a negative regulator of Notch function.

PubMed ID
PubMed Central ID
PMC1460411 (PMC) (EuropePMC)
DOI
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
    Data From Reference
    Aberrations (9)
    Alleles (14)
    Gene Groups (1)
    Genes (8)
    Insertions (1)
    Transgenic Constructs (1)