FlyBase Allele Report: Dmel\N[nd-p]

General Information

Symbol

Dmel\N^nd-p

Species

D. melanogaster

Name

FlyBase ID

FBal0141642

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

P{}N^nd-p

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Tsubota et al., 2011)

Mutagen

Delta2-3 transposase

(Tsubota et al., 2011)

Progenitor genotype

Associated Insertion(s)

P{}N^nd-p

Cytology

Description

Insertion of a 1.1kb P-element in the 5'UTR, 378bp upstream of the translation start site.

(Tsubota et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(1)N-8)

(Tsubota et al., 2011)

lethal (with Df(1)N-81k1)

(Tsubota et al., 2011)

lethal (with N^55e11)

(Tsubota et al., 2011)

lethal (with N^Co)

(Tsubota et al., 2011)

visible

(Tsubota et al., 2011)

Phenotype Manifest In

wing

(Tsubota et al., 2011, Tsubota et al., 2003)

Detailed Description

Statement

Reference

Most mutant flies appear wild type, but occasional apical wing nicks are seen.

(Tsubota et al., 2011)

Occasionally the mutants display apical wing notches.

(Tsubota et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

N^nd-p has visible phenotype, enhanceable by e(r)^p2

(Tsubota et al., 2011)

Suppressed by

Statement

Reference

N^nd-p, e(r)^p2 has lethal phenotype, suppressible by H¹

(Tsubota et al., 2011)

Other

Statement

Reference

N^nd-p, e(r)^p2 has lethal phenotype

(Tsubota et al., 2011, Gelsthorpe et al., 2006)

N^nd-p, e(r)^27-1 has lethal phenotype

(Tsubota et al., 2011)

N^nd-p, e(r)^37-6 has lethal phenotype

(Tsubota et al., 2011)

H¹, N^nd-p, e(r)^p2 has viable phenotype

(Tsubota et al., 2011)

N^nd-p, e(r)[+]/e(r)^p2 has lethal | dominant phenotype

(Tsubota et al., 2003)

N^nd-p/N[+], e(r)^p2 has lethal | dominant phenotype

(Tsubota et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

N^nd-p has wing phenotype, enhanceable by e(r)^p2

(Tsubota et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

The N^nd-p e(r)^p2 combination results in lethality. The few male escapers have severely notched wings.

(Tsubota et al., 2011)

e(r)^p2 N^nd-p flies show synthetic lethality.

(Gelsthorpe et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

N^fa-g

(Tsubota et al., 2011)

N^spl-1

(Tsubota et al., 2011)

N^fa-swb

(Tsubota et al., 2011)

Fails to complement

N^nd-3

(Tsubota et al., 2011)

N^nd-1

(Tsubota et al., 2011)

N^nd-3

(Tsubota et al., 2003)

N^nd-1

(Tsubota et al., 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Precise excision of the insertion reverts the lethal phenotype of the N^nd-p e(r)^p2 combination.

(Tsubota et al., 2011)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

N^nd-p

(Tsubota et al., 2011, Gelsthorpe et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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