FlyBase Allele Report: Dmel\e(r)[27-1]

General Information

Symbol

Dmel\e(r)^27-1

Species

D. melanogaster

Name

FlyBase ID

FBal0217524

Feature type

allele

Associated gene

Dmel\e(r)

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Roykhman et al., 2007)

Mutagen

Progenitor genotype

Caused by aberration

Df(1)e(r)27-1

Cytology

Description

Df(1)e(r)27-1 removes the 5' end of the e(r) gene including the coding region of the first 35 of the 104 amino acids.

(Roykhman et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority live

(Roykhman et al., 2007)

Phenotype Manifest In

Detailed Description

Statement

Reference

e(r)^27-1 mutants exhibit low viability. e(r)^27-1 hemizygous males have a much lower viability than their heterozygous sisters.

Homozygous e(r)^27-1 mutant females are approximately 35% as viable as their heterozygous sisters.

(Roykhman et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

dx¹, e(r)^27-1 has lethal phenotype, suppressible | partially by Dp(1;3)DC109

(Tsubota et al., 2011)

Other

Statement

Reference

N^nd-1, e(r)^27-1 has lethal phenotype

(Tsubota et al., 2011)

N^nd-3, e(r)^27-1 has lethal phenotype

(Tsubota et al., 2011)

N^nd-p, e(r)^27-1 has lethal phenotype

(Tsubota et al., 2011)

dx¹, e(r)^27-1 has lethal phenotype

(Tsubota et al., 2011)

Delta³/Dl[+], e(r)^27-1 has partially lethal - majority die phenotype

(Tsubota et al., 2011)

Delta^6B/Dl[+], e(r)^27-1 has partially lethal - majority die phenotype

(Tsubota et al., 2011)

Ser¹/Ser[+], e(r)^27-1 has viable phenotype

(Tsubota et al., 2011)

N^Rev1, e(r)^27-1 has viable phenotype

(Tsubota et al., 2011)

Phenotype Manifest In

Enhancer of

Statement

Reference

e(r)^27-1 is an enhancer of wing margin bristle phenotype of r^hd1

(Roykhman et al., 2007)

e(r)^27-1 is an enhancer of wing phenotype of r^hd1

(Roykhman et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The presence of a e(r)^27-1 mutant background noticeably enhances the r^hd1 wing phenotype.

(Roykhman et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

e(r)^27-1 is rescued by e(r)^PS

(Roykhman et al., 2007)

Comments

A zygotic copy of e(r)^PS rescues the low viability of e(r)^27-1 mutant males and females. e(r)^PS has little effect on the viability of heterozygous females.

The reduced fertility of e(r)^27-1 homozygous females can be rescued by e(r)^PS.

(Roykhman et al., 2007)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

e(r)^27-1

(Tsubota et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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