FlyBase Allele Report: Dmel\dx[1]

General Information

Symbol

Dmel\dx¹

Species

D. melanogaster

Name

FlyBase ID

FBal0003261

Feature type

allele

Associated gene

Dmel\dx

Associated Insertion(s)

Carried in Construct

Also Known As

Key Links

Allele class

loss of function allele

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Fuwa et al., 2006)

loss of function allele

(Gorman and Girton, 1992)

Mutagen

spontaneous

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

flightless | recessive

(Gorman and Girton, 1992)

flightless | recessive | heat sensitive

(Xu and Artavanis-Tsakonas, 1990)

viable

(Tsubota et al., 2011)

visible

(Fuwa et al., 2006, Thumm and Kadowaki, 2001)

visible (with dx¹⁵²)

(Fuwa et al., 2006)

visible | recessive

(Xu and Artavanis-Tsakonas, 1990)

Phenotype Manifest In

eye

(Busseau et al., 1994)

ocellus

(Busseau et al., 1994)

wing

(Royet et al., 1998, Busseau et al., 1994)

wing (with dx¹⁵²)

(Fuwa et al., 2006)

wing vein

(Fuwa et al., 2006, Thumm and Kadowaki, 2001, Royet et al., 1998)

wing vein (with dx¹⁵²)

(Fuwa et al., 2006)

Detailed Description

Statement

Reference

No wing notching is seen in dx¹/+ mutant flies.

(Mishra et al., 2014)

Homozygous and dx¹/dx¹⁵² flies show wing vein thickening, with the severity of the phenotype being stronger in the dx¹/dx¹⁵² flies (which can show wing notching).

(Fuwa et al., 2006)

dx¹ mutant larvae have normal wild-type numbers of crystal cells.

(Duvic et al., 2002)

dx¹/Y flies show terminal deltas in wing veins.

(Thumm and Kadowaki, 2001)

Phenotype resembles reduction of N activity: nicking of distal region of wing blade and thickening of wing veins.

(Royet et al., 1998)

Wings have thick veins and nicks at or between veins III and IV. Wings are held out. Slight eye roughness: irregular shape and organization of facets, some bristles are duplicated. Ocelli are closer than normal, bristles between them are not properly spaced and sometimes missing. Thorax and leg bristle placements are disorganized, extra or doubled bristles may also be seen on the eye, leg, head and scutellum. Temperature- dependent wing phenotype: less severe at 18^oC, more severe at 29^oC.

(Gorman and Girton, 1992)

Viable. Extra vein material at tips, infrequent wing notching, ocelli are abnormal. Weak rough eye phenotype: irregular ommatidia, bristles are duplicated or missing. No visual abnormality. Temperature-dependent flightless: cannot fly at 25^oC, normal flight at 18^oC.

(Xu and Artavanis-Tsakonas, 1990)

Veins show thickenings and terminal deltas; resembles Dl in third chromosomes except fully viable, fertile and easily classified. Nearly suppressed by su(dx), Su(dx) and Su(dx)². RK2.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dx¹ has visible phenotype, enhanceable by Atg4b^P0997/Atg4b^P0997

(Thumm and Kadowaki, 2001)

Suppressed by

Statement

Reference

dx¹, e(r)^27-1 has lethal phenotype, suppressible | partially by Dp(1;3)DC109

(Tsubota et al., 2011)

Enhancer of

Statement

Reference

dx¹/dx[+] is an enhancer of visible phenotype of Scer\GAL4^A9, uif^asterisk.UAS

(Xie et al., 2012)

dx¹ is an enhancer of visible phenotype of Hs3st-B^RNAi.UAS, Scer\GAL4^dpp.blk1

(Kamimura et al., 2004)

dx¹ is an enhancer of visible phenotype of Scer\GAL4^bbg-C96, mam^N.UAS

(Helms et al., 1999)

dx¹ is an enhancer of visible phenotype of N^act.sev

(Matsuno et al., 1997)

Other

Statement

Reference

dx¹, e(r)^27-1 has lethal phenotype

(Tsubota et al., 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

dx¹ has wing vein phenotype, enhanceable by Atg4b^P0997/Atg4b^P0997

(Thumm and Kadowaki, 2001)

Suppressed by

Statement

Reference

dx¹ has wing vein phenotype, suppressible by Nle^Δ8

(Royet et al., 1998)

dx¹ has wing phenotype, suppressible by Nle^k13714

(Royet et al., 1998)

dx¹ has wing vein phenotype, suppressible by Nle^k13714

(Royet et al., 1998)

dx¹ has wing phenotype, suppressible by Nle^Δ8

(Royet et al., 1998)

dx¹ has wing phenotype, suppressible by Su(dx)[+]/Su(dx)¹

(Busseau et al., 1994)

dx¹ has eye phenotype, suppressible by Su(dx)[+]/Su(dx)¹

(Busseau et al., 1994)

dx¹ has ocellus phenotype, suppressible by Su(dx)[+]/Su(dx)¹

(Busseau et al., 1994)

dx¹ has wing phenotype, suppressible by Su(dx)^sp/Su(dx)[+]

(Busseau et al., 1994)

dx¹ has eye phenotype, suppressible by Su(dx)^sp/Su(dx)[+]

(Busseau et al., 1994)

dx¹ has ocellus phenotype, suppressible by Su(dx)^sp/Su(dx)[+]

(Busseau et al., 1994)

Enhancer of

Statement

Reference

dx¹/dx[+] is an enhancer of wing vein phenotype of Scer\GAL4^A9, uif^asterisk.UAS

(Xie et al., 2012)

dx¹ is an enhancer of wing vein L3 phenotype of Hs3st-B^RNAi.UAS, Scer\GAL4^dpp.blk1

(Kamimura et al., 2004)

dx¹ is an enhancer of anterior scutellar bristle phenotype of Hs3st-B^RNAi.UAS, Scer\GAL4^dpp.blk1

(Kamimura et al., 2004)

dx¹ is an enhancer of posterior scutellar bristle phenotype of Hs3st-B^RNAi.UAS, Scer\GAL4^dpp.blk1

(Kamimura et al., 2004)

dx¹ is an enhancer of photoreceptor cell R3 phenotype of N^act.sev

(Matsuno et al., 1997)

dx¹ is an enhancer of photoreceptor cell R4 phenotype of N^act.sev

(Matsuno et al., 1997)

dx¹ is an enhancer of photoreceptor cell R7 phenotype of N^act.sev

(Matsuno et al., 1997)

Other

Statement

Reference

da², dx¹/dx[+] has follicle cell phenotype

(Smith et al., 2002)

da², dx¹ has follicle cell phenotype

(Smith et al., 2002)

Atg4b^P0997, dx¹ has wing margin phenotype

(Thumm and Kadowaki, 2001)

Additional Comments

Genetic Interactions

Statement

Reference

dx¹/Traf6^ex1 transheterozygotes exhibit a wing vein thickening phenotype.

(Mishra et al., 2014)

The wing vein phenotype resulting from the expression of uif^{asterisk.Scer\UAS} under the control of Scer\GAL4^A9 is enhanced by dx¹.

(Xie et al., 2012)

CG6194^P0997/CG6194^P0997 enhances wing vein thickenings and wing margin loss in dx¹/Y flies.

(Thumm and Kadowaki, 2001)

The addition of dx¹/Y enhances the wing nicking phenotype seen in mam^N.Scer\UAS, Scer\GAL4^C96 flies.

(Helms et al., 1999)

No effect on the faf eye phenotype.

(Huang and Fischer-Vize, 1996)

The mutant wing, eye and ocelli phenotypes are dominantly suppressed by Su(dx)¹, Su(dx)² and Su(dx)^sp.

(Busseau et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

ec¹ dx¹

Kyoto

105744

su(dx)r¹ dx¹

Notes on Origin

Discoverer

Bridges, 26 Aug. 1922.

Comments

Weak dx allele.

(Xu and Artavanis-Tsakonas, 1990)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Dx¹

(Xie et al., 2012, Duvic et al., 2002)

deltex¹

(Royet et al., 1998)

(Sachan et al., 2015, Tsubota et al., 2011)

dx¹

(Zhu et al., 2017, Muñoz-Soriano et al., 2016, Popodi et al., 2010-, Fuwa et al., 2006, Kamimura et al., 2004, Kamimura et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (22)

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