FlyBase Allele Report: Dmel\Delta[3]

General Information

Symbol

Dmel\Delta³

Species

D. melanogaster

Name

FlyBase ID

FBal0002460

Feature type

allele

Associated gene

Dmel\Delta

Associated Insertion(s)

Carried in Construct

Also Known As

Dl³

Key Links

Allele class

loss of function allele

Mutagen

spontaneous

Nature of the Allele

Allele class

loss of function allele

(Long et al., 1996)

Mutagen

spontaneous

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Shepard et al., 1989)

visible

(Schultz, 1929)

visible | adult stage

(Imai et al., 2015)

visible | dominant

(Tian et al., 2004)

Phenotype Manifest In

Detailed Description

Statement

Reference

About 25% of Dl³ heterozygote adults display vein thickening phenotype.

(Imai et al., 2015)

Heterozygous flies show a mild vein thickening along the length and at the distal tip of wing vein L2, bifurcation of the posterior crossvein at its junction with vein L5, thickening of vein L5 at the distal tip and a thickening of vein L4 at its junction with the anterior crossvein.

(Tian et al., 2004)

The RP2 motoneuron duplicated at the expense of the RP2sib. The aCC motoneuron is duplicated at the expense of the pCC interneuron. The Usib fates are duplicated at the expense of the U neurons. The dMP2 is duplicated at the expense of the vMP2. No change was observable in EL cell fate. This phenotype is the reciprocal of that shown for numb mutants. Mutant embryos show excess neuroblast formation characteristic of neurogenic mutants.

(Skeath and Doe, 1998)

Assymetric division of all the MP2 precursors formed is not altered, but the smaller vMP2 is transformed to the dMP2 fate. In numb¹ Dl³ double mutants all MP2 neurons develop as dMP2.

(Spana and Doe, 1996)

Individuals heterozygous for Bpt¹ and heterozygous for Dl³ exhibit no Bpt¹ phenotype.

(Duus et al., 1992)

Lethal or semi-lethal when in combination with large deficiency alleles of E(spl) or Df(3R)Espl3. suppressor Extragenic suppressor of the N^spl-1-E(spl)¹ interaction.

(Shepard et al., 1989)

Dl³ shows similar although less severe phenotypes to Dl¹. In contrast to Dl¹, Dl³ shows a thickening at the crossveins.

(Schultz, 1929)

Like Dl¹ but deltas at margin are slight; longitudinal veins between anterior and posterior crossveins and crossveins themselves are thickened. Spreading of wing slighter than in Dl¹. Better viability than Dl¹. homozygous lethal. RK1.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Delta³ has visible | adult stage phenotype, enhanceable by Lrrk[+]/Lrrk^e03680

(Imai et al., 2015)

Delta³ has visible | adult stage phenotype, enhanceable by Neurl4[+]/Neurl4^47b-2

(Imai et al., 2015)

Delta³ has visible | dominant phenotype, enhanceable by lqf[+]/lqf^ARI

(Tian et al., 2004)

Enhancer of

Statement

Reference

Delta³ is an enhancer of visible phenotype of Myt1^GMR.PP

(Price et al., 2002)

Suppressor of

Statement

Reference

Delta³ is a suppressor of visible phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

Other

Statement

Reference

Delta³/Dl[+], e(r)^27-1 has partially lethal - majority die phenotype

(Tsubota et al., 2011)

Delta³, RpS3[+]/RpS3¹ has viable phenotype

(Schultz, 1929)

Delta³, M(2)31A[+]/M(2)31A¹ has viable phenotype

(Schultz, 1929)

Delta³, M(3)99E¹/M(3)99E[+] has viable phenotype

(Schultz, 1929)

Delta³, M(3)96CF¹ has lethal | dominant phenotype

(Schultz, 1929)

Delta³, Df(2R)M58F has partially lethal - majority die | dominant phenotype

(Schultz, 1929)

Delta³/Dl[+], M(2)31A¹ has viable phenotype

(Schultz, 1929)

Delta³/Dl[+], M(3)96CF¹ has lethal | dominant phenotype

(Schultz, 1929)

Delta³/Dl[+], M(3)99E¹ has viable phenotype

(Schultz, 1929)

Delta³/Dl[+], RpS3¹ has viable phenotype

(Schultz, 1929)

Phenotype Manifest In

Enhanced by

Statement

Reference

Delta³ has wing vein | adult stage phenotype, enhanceable by Neurl4[+]/Neurl4^47b-2

(Imai et al., 2015)

Delta³ has wing vein | adult stage phenotype, enhanceable by Lrrk[+]/Lrrk^e03680

(Imai et al., 2015)

Delta³ has posterior crossvein phenotype, enhanceable by lqf[+]/lqf^ARI

(Tian et al., 2004)

Delta³ has wing vein L2 | distal phenotype, enhanceable by lqf[+]/lqf^ARI

(Tian et al., 2004)

Delta³ has wing vein L2 phenotype, enhanceable by lqf[+]/lqf^ARI

(Tian et al., 2004)

Delta³ has wing vein L4 phenotype, enhanceable by lqf[+]/lqf^ARI

(Tian et al., 2004)

Delta³ has wing vein L5 | distal phenotype, enhanceable by lqf[+]/lqf^ARI

(Tian et al., 2004)

Suppressed by

Statement

Reference

Delta³ has wing vein phenotype, suppressible by sno^71e3

(Coyle-Thompson and Banerjee, 1993)

Delta³ has phenotype, suppressible by S¹

(Schultz, 1929)

NOT suppressed by

Statement

Reference

Delta³ has phenotype, non-suppressible by Dp(2;3)P

(Schultz, 1929)

Enhancer of

Statement

Reference

Delta³/Dl[+] is an enhancer of dorsal vessel wall cell | increased number phenotype of lqf^ARI

(Tian et al., 2004)

Delta³ is an enhancer of eye phenotype of Myt1^GMR.PP

(Price et al., 2002)

Suppressor of

Statement

Reference

Delta³ is a suppressor of eye phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

Other

Statement

Reference

Delta³, stl[+]/stl⁴ has ovariole phenotype

(Ozdowski et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The frequency of the vein thickening phenotype observed in Dl³ heterozygote adults is significantly increased by combination with a single copy of either Lrrk^e03680 or Neurl4^47b-2.

(Imai et al., 2015)

96.1% of stl⁴/+ ; Dl³/+ ovarioles have compound or morphologically disrupted follicles.

(Ozdowski et al., 2009)

Heterozygosity for Dl³ increases the frequency of lqf^ARI embryos that show an excess cardioblast phenotype at 18^oC. lqf^ARI dominantly enhances the expressivity and penetrance of all Dl³/+ wing vein phenotypes.

(Tian et al., 2004)

The confluens phenotype of Dl³ is suppressed by sno^71e3.

(Coyle-Thompson and Banerjee, 1993)

Dl³ is viable in double heterozygous combination with RpS3¹, M(2)31A¹ or M(3)99E¹.

(Schultz, 1929)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement