FlyBase Allele Report: Dmel\ed[4.12]

General Information

Symbol

Dmel\ed^4.12

Species

D. melanogaster

Name

FlyBase ID

FBal0152008

Feature type

allele

Associated gene

Dmel\ed

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Rawlins et al., 2003)

Progenitor genotype

Cytology

Description

Amino acid replacement: single amino acid change.

(Rawlins et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Rawlins et al., 2003)

viable (with ed^lH23)

(Rawlins et al., 2003)

visible

(Rawlins et al., 2003)

visible (with ed^lH23)

(Rawlins et al., 2003)

Phenotype Manifest In

adult thorax & microchaeta | ectopic

(Rawlins et al., 2003)

chemosensory ventral triple row & microchaeta | ectopic

(Rawlins et al., 2003)

dorsal triple row & macrochaeta | ectopic

(Rawlins et al., 2003)

dorsocentral bristle | ectopic

(Rawlins et al., 2003)

eye photoreceptor cell

(Rawlins et al., 2003)

ommatidium

(Rawlins et al., 2003)

ommatidium (with ed^lH23)

(Rawlins et al., 2003)

photoreceptor cell R7 | increased number

(Rawlins et al., 2003)

photoreceptor cell R8 | increased number

(Rawlins et al., 2003)

photoreceptor cell R8 | increased number (with Df(2L)ed-dp)

(Rawlins et al., 2003)

photoreceptor cell R8 | increased number (with ed^4.4)

(Rawlins et al., 2003)

photoreceptor cell R8 | increased number (with ed^6.1)

(Rawlins et al., 2003)

scutellar bristle | ectopic

(Rawlins et al., 2003)

Detailed Description

Statement

Reference

Homozygotes and ed^4.12/ed^lH23 flies have a rough eye phenotype. Twinning of R8 photoreceptor cells is seen in ed^4.12/ed^4.12, ed^4.12/ed^4.4, ed^4.12/ed^6.1 and ed^4.12/Df(2L)ed-dp animals. Variation in the number and arrangement of R7 and other photoreceptors is seen in ed^4.12 eyes. The presence of extra R7 cells is correlated very strongly with the presence of extra R8 cells.

(Rawlins et al., 2003)

ed^4.12 homozygous flies have extra dorsocentral, scutellar and recurved wing margin bristles (chemosensory ventral triple row + dorsal triple row). They also have extra thoracic microchaetae.

(Rawlins et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

ed[+]/ed^4.12 is an enhancer of visible phenotype of Scer\GAL4^sca-109-68, ato^UAS.cJa

(Rawlins et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

ed^4.12 has photoreceptor cell R8 | increased number phenotype, enhanceable by aos^Δ7/argos[+]

(Rawlins et al., 2003)

NOT Enhanced by

Statement

Reference

ed^4.12 has photoreceptor cell R8 | increased number phenotype, non-enhanceable by N[+]/N^55e11

(Rawlins et al., 2003)

ed^4.12 has photoreceptor cell R8 | increased number phenotype, non-enhanceable by spi^SC2

(Rawlins et al., 2003)

ed^4.12 has chemosensory ventral triple row & microchaeta | ectopic phenotype, non-enhanceable by aos^Δ7

(Rawlins et al., 2003)

ed^4.12 has dorsal triple row & microchaeta | ectopic phenotype, non-enhanceable by aos^Δ7

(Rawlins et al., 2003)

ed^4.12 has dorsocentral bristle | ectopic phenotype, non-enhanceable by aos^Δ7

(Rawlins et al., 2003)

ed^4.12 has scutellar bristle | ectopic phenotype, non-enhanceable by aos^Δ7

(Rawlins et al., 2003)

ed^4.12 has chemosensory ventral triple row & microchaeta | ectopic phenotype, non-enhanceable by Egfr[+]/Egfr^f2

(Rawlins et al., 2003)

ed^4.12 has dorsal triple row & microchaeta | ectopic phenotype, non-enhanceable by Egfr[+]/Egfr^f2

(Rawlins et al., 2003)

ed^4.12 has dorsocentral bristle | ectopic phenotype, non-enhanceable by Egfr[+]/Egfr^f2

(Rawlins et al., 2003)

ed^4.12 has scutellar bristle | ectopic phenotype, non-enhanceable by Egfr[+]/Egfr^f2

(Rawlins et al., 2003)

Suppressed by

Statement

Reference

ed^4.12 has photoreceptor cell R8 | increased number phenotype, suppressible by Egfr[+]/Egfr^f2

(Rawlins et al., 2003)

ed^4.12 has photoreceptor cell R8 | increased number phenotype, suppressible by Ras85D[+]/Ras85D^unspecified

(Rawlins et al., 2003)

ed^4.12 has photoreceptor cell R8 | increased number phenotype, suppressible by Egfr^f2/Egfr^f2

(Rawlins et al., 2003)

ed^4.12 has chemosensory ventral triple row & microchaeta | ectopic phenotype, suppressible by H¹

(Rawlins et al., 2003)

ed^4.12 has dorsal triple row & microchaeta | ectopic phenotype, suppressible by H¹

(Rawlins et al., 2003)

ed^4.12 has dorsocentral bristle | ectopic phenotype, suppressible by H¹

(Rawlins et al., 2003)

ed^4.12 has dorsocentral bristle | ectopic phenotype, suppressible by Df(1)ase-1/+

(Rawlins et al., 2003)

ed^4.12 has scutellar bristle | ectopic phenotype, suppressible by Df(1)ase-1/+

(Rawlins et al., 2003)

ed^4.12 has scutellar bristle | ectopic phenotype, suppressible by Df(1)sc-B57/+

(Rawlins et al., 2003)

ed^4.12 has scutellar bristle | ectopic phenotype, suppressible by H¹

(Rawlins et al., 2003)

ed^4.12 has dorsocentral bristle | ectopic phenotype, suppressible by Df(1)sc-B57/+

(Rawlins et al., 2003)

NOT suppressed by

Statement

Reference

ed^4.12 has photoreceptor cell R8 | increased number phenotype, non-suppressible by spi^SC2

(Rawlins et al., 2003)

ed^4.12 has photoreceptor cell R8 | increased number phenotype, non-suppressible by N[+]/N^55e11

(Rawlins et al., 2003)

ed^4.12 has chemosensory ventral triple row & microchaeta | ectopic phenotype, non-suppressible by Egfr[+]/Egfr^f2

(Rawlins et al., 2003)

ed^4.12 has chemosensory ventral triple row & microchaeta | ectopic phenotype, non-suppressible by aos^Δ7

(Rawlins et al., 2003)

ed^4.12 has dorsal triple row & microchaeta | ectopic phenotype, non-suppressible by Egfr[+]/Egfr^f2

(Rawlins et al., 2003)

ed^4.12 has dorsal triple row & microchaeta | ectopic phenotype, non-suppressible by aos^Δ7

(Rawlins et al., 2003)

ed^4.12 has dorsocentral bristle | ectopic phenotype, non-suppressible by Egfr[+]/Egfr^f2

(Rawlins et al., 2003)

ed^4.12 has dorsocentral bristle | ectopic phenotype, non-suppressible by aos^Δ7

(Rawlins et al., 2003)

ed^4.12 has scutellar bristle | ectopic phenotype, non-suppressible by Egfr[+]/Egfr^f2

(Rawlins et al., 2003)

ed^4.12 has scutellar bristle | ectopic phenotype, non-suppressible by aos^Δ7

(Rawlins et al., 2003)

Enhancer of

Statement

Reference

ed[+]/ed^4.12 is an enhancer of ommatidium phenotype of Scer\GAL4^sca-109-68, ato^UAS.cJa

(Rawlins et al., 2003)

ed[+]/ed^4.12 is an enhancer of photoreceptor cell R8 | increased number phenotype of Scer\GAL4^sca-109-68, ato^UAS.cJa

(Rawlins et al., 2003)

ed^4.12 is an enhancer of scutellar bristle | ectopic phenotype of Scer\GAL4^sca-109-68, sc^UAS.cCa

(Rawlins et al., 2003)

Suppressor of

Statement

Reference

ed^4.12 is a suppressor of phenotype of ato²

(Rawlins et al., 2003)

Other

Statement

Reference

Delta^unspecified, ed^4.12 has trichogen cell | ectopic phenotype

(Rawlins et al., 2003)

N^55e11, ed^4.12 has trichogen cell phenotype

(Rawlins et al., 2003)

N[+]/N^55e11, ed^4.12 has eo neuron | ectopic phenotype

(Rawlins et al., 2003)

N^55e11, ed^4.12 has tormogen cell phenotype

(Rawlins et al., 2003)

N^55e11, ed^4.12 has sensory mother cell | ectopic phenotype

(Rawlins et al., 2003)

N^55e11, ed^4.12 has thecogen cell phenotype

(Rawlins et al., 2003)

N^55e11, ed^4.12 has eo neuron | ectopic phenotype

(Rawlins et al., 2003)

N[+]/N^55e11, ed^4.12 has trichogen cell phenotype

(Rawlins et al., 2003)

N[+]/N^55e11, ed^4.12 has tormogen cell phenotype

(Rawlins et al., 2003)

N[+]/N^55e11, ed^4.12 has sensory mother cell | ectopic phenotype

(Rawlins et al., 2003)

N[+]/N^55e11, ed^4.12 has thecogen cell phenotype

(Rawlins et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The rough eye phenotype and R8 cell twinning phenotype caused by expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68 is dominantly enhanced by ed^4.12. The ed^4.12 R8 cell twinning phenotype is not altered by N^55e11/+. The ed^4.12 R8 cell twinning phenotype is strongly suppressed by Egfr^f2/+ or Ras85D^unspecified/+. The ed^4.12 R8 cell twinning phenotype is strongly enhanced by argos^Δ7/+. Egfr^f2 clones in the eye disc induced in a homozygous ed^4.12 background show abnormal spacing of R8 cells in the clone, but R8 cells rarely appear twinned. The ed^4.12 R8 cell twinning phenotype is not affected in spi^SC2 homozygous clones in a ed^4.12 background.

(Rawlins et al., 2003)

ed^4.12/ed^4.12; N^55e11/+ flies have an increased number of sensillum precursor cells specified. In many instances these sensillum precursor cells divide to produce four neurons rather than the wild type external sensory organ. ed^4.12/ed^4.12; Dl^unspecified/+ flies have additional shaft (trichogen) cells The increased bristle number in ed^4.12; sca^BP2 double homozygotes is consistent with an additive rather than a synergistic effect of the two muations.

(Rawlins et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a modifier of the rough eye phenotype caused by expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68.

(Rawlins et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

E(ato^109-68)4.12

(Rawlins et al., 2003)

ed^4.12

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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